Abstract
Background
Spondylodiscitis is a spinal infection affecting primarily the intervertebral disk and the adjacent vertebral bodies. Currently many aspects of the treatment of pyogenic spondylodiscitis are still a matter of debate.
Purpose
The aim of this study was to review the currently available literature systematically to determine the outcome of patients with pyogenic spondylodiscitis for conservative and surgical treatment strategies.
Methods
A systematic electronic search of MEDLINE, EMBASE, Cochrane Collaboration, and Web of Science regarding the treatment of pyogenic spondylodiscitis was performed. Included articles were assessed on risk of bias according the Cochrane Handbook for Systematic Reviews of Interventions, and the quality of evidence and strength of recommendation was evaluated according the GRADE approach.
Results
25 studies were included. Five studies had a high or moderate quality of evidence. One RCT suggest that 6 weeks of antibiotic treatment of pyogenic spondylodiscitis results in a similar outcome when compared to longer treatment duration. However, microorganism-specific studies suggest that at least 8 weeks of treatment is required for S. aureus and 8 weeks of Daptomycin for MRSA. The articles that described the outcome of surgical treatment strategies show that a large variety of surgical techniques can successfully treat spondylodiscitis. No additional long-term beneficial effect of surgical treatment could be shown in the studies comparing surgical versus antibiotic only treatment.
Conclusion
There is a strong level of recommendation for 6 weeks of antibiotic treatment in pyogenic spondylodiscitis although this has only been shown by one recent RCT. If surgical treatment is indicated, it has been suggested by two prospective studies with strong level of recommendation that an isolated anterior approach could result in a better clinical outcome.
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Introduction
Spondylodiscitis, also known as vertebral osteomyelitis or bacterial spondylitis, is the most common spinal infection, which affects the intervertebral disk, adjacent vertebral bodies, and occasionally also the posterior elements of the spine [1, 2]. The incidence of spondylodiscitis ranges from 0.2 till 2.4 per 100.000 per year in the Western countries [2, 3]. Generally three types of spondylodiscitis are recognized; pyogenic, granulomatous (tuberculous, brucellar, aspergillar, and fungal), and parasitic [2, 4]. In the mid twentieth century, the majority of the reported cases in literature consisted of granulomatous infections with up to 59 % of the cases caused by Mycobacterium tuberculosis [3, 5, 6]. The name granulomatous spondylodiscitis is somewhat misleading since spinal tuberculosis typically involves the vertebral bodies and to lesser extent the intervertebral disks. Nowadays, only 24 % is caused by tuberculosis and the vast majority of the cases of spinal infections are pyogenic [3, 5, 6]. Besides a relative increase in pyogenic spondylodiscitis, there also appears to be an increase in the total incidence [1, 3, 7, 8]. This increase in incidence is thought to be caused by the aging population, by the rise of immunosuppressed patients, of intravenous drug use and of improved diagnostic possibilities [1, 3, 7, 8].
Although diagnostic and therapeutic possibilities have drastically improved during the past decades, pyogenic spondylodiscitis remains a diagnostic and therapeutic challenge. Since it is often a complication of a distant process causing bacteremia, the relatively nonspecific array of symptoms of spondylodiscitis may be initially dominated by the primary infection [9]. Consequently, clinical presentation is often unclear and a considerable delay in diagnosis frequently occurs [2, 3, 10]. Spondylodiscitis remains a life-threatening disease with a mortality rate of 2–20 % [10, 11]. Although some therapeutic guidelines are available, treatment of spondylodiscitis is certainly not standardized and is mostly based on local preferences resulting in physician-related variability [12–15]. Conservative treatment, comprising of long-term antibiotics optionally combined with bed rest and/or an orthosis, appears to be the treatment of choice for the majority of the patients [3]. However, there is still debate about the optimal duration of intravenous and oral antibiotic treatment. Furthermore is it unclear whether there is a relation between treatment duration and relapse or treatment failure.
Apart from the antibiotic treatment, some of the cases with pyogenic spondylodiscitis may require surgical debridement and stabilization. The indications for surgery are compression of neurological structures, mechanical instability, spinal deformity, and failure of adequate conservative treatment. However, there is an enormous variation in surgical techniques described for the treatment of pyogenic spondylodiscitis [1–3, 10, 11]. Classically anterior debridement and stabilization has been the preferred treatment, since the anterior part of the spine is the most commonly involved in spondylodiscitis [2]. In recent literature, however, both more elaborated combined anterior–posterior approaches, less invasive posterior stabilization, or transpedicular curettage and drainage have been described [16–18]. Whereas the open surgical procedures are thought to reduce the loss of sagittal balance and minimize the risk of relapse, less invasive strategies are a lower burden for the patients with potentially fewer complications [16, 17].
Many fundamental aspects of the treatment of pyogenic spondylodiscitis are still a matter of debate. Therefore, the aim of this study was to systematically review the currently available literature to determine the outcome; defined as relapse rate, treatment failure and mortality; in patients with pyogenic spondylodiscitis after the different antibiotic and/or surgical treatments.
Methods
This systematic literature review regarding the outcomes of treatment of pyogenic spondylodiscitis was preformed according the PRISMA guidelines for systematic reviews and was registered at Prospero; the international register of systematic reviews (http://www.crd.york.ac.uk/PROSPERO) [19, 20], registration number: CRD42015020618.
Literature search
We conducted an electronic search of databases of MEDLINE, EMBASE, Cochrane Collaboration, and Web of Science on the 1st of January 2015 for articles in English language regarding treatment of spondylodiscitis that were published since 2000 [21–24]. We used a standardized search strategy including search keywords (spondylodiscitis, vertebral osteomyelitis, osteodiscitis, discitis, treatment, therapy, antibiotics, and surgery). In addition, to prevent omission of relevant articles from before 2000, the references of the included articles and recent reviews regarding the treatment of spondylodiscitis were screened for relevant literature [1–3, 10, 11]. Literature before 2000 was not systematically assessed since research before 2000 was predominantly focused on infections caused by tuberculosis. Details about the used search strategy are presented in Table 1.
Study selection
A stepwise procedure to identify relevant studies was used. First, the title and abstract of all articles were systematically assessed using the inclusion and exclusion criteria as described in Table 2. Second, all included articles were assessed full text by two independent reviewers (JR and DK). This critical appraisal was performed according to the Cochrane Handbook for Systematic Reviews of Interventions 5.1.0 [25]. In order to determine the extent of selection bias, the selection procedures and the homogeneity of the patient populations were examined. The studies were also assessed on the standardization of antibiotic treatment, operative procedure and peri- and postoperative care in order to determine the risk on performance bias. Attrition bias was scored on the basis of percentage follow-up and exclusion criteria. The risk on detection bias was based on the description of how the data was acquired (for example blinding) and how statistical analysis was performed.
Quality assessment
The quality of evidence and strength of recommendation was assessed according to the GRADE approach [26]. Details regarding treatment strategy (for example: antibiotics, thoracolumbosacral orthosis (TLSO) or surgery) and outcome parameters (treatment duration, required additional surgery, treatment failure, relapse, and mortality) were registered by two independent reviewers (JR and DK). Relapse was defined as every event that required additional conservative or surgical treatment after finishing the initial treatment. Treatment failure was defined as active infectious disease 1 year after start of the treatment. Differences in risk of bias, quality of evidence, strength of recommendation, and outcome parameters were discussed in a consensus meeting.
Results
Study selection
A total of 1662 articles were found in the four electronic databases (Fig. 1). After screening the titles and abstracts, 65 full-text articles were reviewed. Of these full-text manuscripts, 25 articles were excluded since they did not meet de inclusion criteria. Most common reason for exclusion was description of non-pyogenic spondylodiscitis (13 articles) such as postoperative or tuberculosis infection. Furthermore, 16 abstracts of scientific conferences were found which were not included in the critical appraisal. Relevant abstracts were incorporated in the discussion section of the review. One article published before 2000 was included after reference tracking of included articles and de recent reviews regarding the treatment of spondylodiscitis [6]. This resulted in 25 included studies (Table 3). Ten studies containing only a minority of tuberculosis or postoperative infection cases (2.9–38 %) were included in the review [16–18, 27–33]. At total of 75 patients in the current review had tuberculosis and 52 patients had a postoperative infection, which represented, respectively, 3.1 and 2.2 % of all included patients. Similarly, four included study populations consisted of 0.9–13.5 % children and adolescent patients [4, 6, 27, 34]. Additionally 3 other studies contained patients between 16 and 18 years of age; however, the number of these patients is not described [32, 35, 36]. A total number of 31 children and adolescents have described in the included studies and represent 1.3 % of the study population in this review [4, 6, 27, 34].
Characteristics of included studies
The majority of 25 included studies were retrospective (n = 20) and only five were prospective. The retrospective studies consisted of 11 retrospective comparative studies (RCoS) and nine retrospective case series (RCS). Additionally, there were three prospective comparative studies (PCS) and 2 randomized controlled trails (RCT) (Table 4).
The combined number of patients in all included studies was 2407 and ranged from 20 to 351 patients per study. The average age of the included patients was 59 years (range 1–90 years). Sixty-one percent of the patients were male. Mean follow-up time of the patients was 24 months and ranged from 3 to 144 months (Table 3).
The reported treatment strategy was systemic antibiotics alone in six studies and a combination of surgery and systemic antibiotics in nine studies. In three studies, systemic antibiotic treatment alone was compared to a combination of surgery and antibiotics. Additionally, five studies focused on the treatment of a specific type of microorganism and two on a specific patient category consisting of HIV patients and intravenous drug users (IVDU).
Quality of included studies
According to the GRADE approach, the quality of evidence was high in one study, moderate in four studies, and very low in 20 studies (Table 4). The strength of recommendation was strong for five studies and weak for the 20 other studies.
Outcomes of systemic antibiotic treatment
Six studies have evaluated the effect of systemic antibiotic treatment alone (Table 5) [4, 30, 31, 35, 37, 38]. Antibiotics therapy could be targeted on the causative bacteria in 792 (89 %) of the cases. Four studies were of a more descriptive nature and reported the outcome after antibiotic therapy [4, 30, 35, 37]. The reported systemic antibiotic treatment duration ranged between 6 and 40 weeks [4, 30, 35]. Despite antibiotic treatment, additional surgery was required in 25–55 % of the reported cases [4, 30]. Relapse rates of 2 and 4 % after antibiotics treatment only were reported in two studies. Whereas one study did not report the microorganisms causing the relapse, the other reported three cases of S. aureus (one case of MRSA), and one case of Proprionibacterium acnes. The in-hospital mortality ranged from 1–10 % [4, 30, 35]. A recent RCT by Bernard et al. compared 6–12 weeks of antibiotic treatment and showed that the therapy can be safely shortened to a total of 6-week treatment without increasing the risk for relapse, failure, and infection-related mortality (Table 5) [38]. An earlier RCoS by Roblot et al. supports this conclusion [31].
Outcomes of surgical treatment
Four studies compared anterior and/or posterior approaches [16, 17, 29, 39]. The RCT of Linhardt et al. and the PCoS of Si et al. both compared a combined anterior and posterior stabilization with an isolated anterior spondylodesis [29, 39]. They both reported less pain and statistically significant better clinical outcomes (SF36, Oswestry, ODI, and VAS) in the anterior only group [29, 39]. The RCoS by Vcelak et al. evaluated the differences between a combined anterior and posterior approach and an isolated posterior approach [17]. No statistically significant differences in reoperation rate, relapse, treatment failure, or mortality were found [17]. The isolated posterior approach group had a statistically significant greater loss of sagittal balance; however, this had no clinical consequences [17].
Lee et al. retrospectively evaluated the outcome of transpedicular curettage and drainage with posterior stabilization versus an combined anterior/posterior stabilization [16]. No differences in clinical outcome were found and the transpedicular curettage, and drainage with posterior stabilization was suggested to be a good treatment for patients with severe co-morbidities [16]. Lin et al. retrospectively assessed the difference between an open and a percutaneous approach in a combined anterior and posterior strategy [40]. They found no differences in the outcomes between the open and percutaneous groups [40]. The retrospective study by Ozturk et al. analyzed if there was a difference between a sequential versus a simultaneous anterior and posterior surgery [18]. No differences were found between the two study groups [18]. Two studies retrospectively compared the effectiveness of anterior fusion with different types of cages and cage versus strut graft [41, 42]. Schomacher et al. compared Polyetheretherketone (PEEK) cages with titanium (TTN) cages [41]. No differences between the two cage types were found [41]. The differences between iliac bone struts and titanium mesh cages were analyzed by Yong et al. [42]. Although there was no difference in clinical outcome, a higher subsidence rate in the strut group was reported [42]. The descriptive RCS by Rossbach et al. presented the results of a cohort of patients with spondylodiscitis and a subgroup in which the spondylodiscitis was complicated by a spinal epidural abscess [32]. Patients with a neurological deficit caused by an epidural abscess had a statistically significant better prognosis than patients with other causes of neurological deficit [32] (Table 6).
Systemic antibiotics versus surgical treatment
Three studies retrospectively compared systemic antibiotics alone versus surgical treatment [27, 34, 43]. The indication for surgical treatment in the first two studies was neurologic compromise, extensive bone destruction, epidural abscess formation, failure of nonoperative treatment or intractable back pain. The descriptive study by Karadimas et al. concluded that nonoperative treatment was effective in 90 % of the patients; decompression alone had a high reoperation rate and no differences in clinical outcome were found [27]. Reoperation rate for decompression without stabilization was 42 %, whereas combined stabilization and decompression had a reoperation rate of 16 % [27]. Although this study reported the complication and reoperation rates in detail, no statistical analysis was performed. Similarly, the retrospective comparative study by Valancius et al. described the results of antibiotics alone and surgical treatment in great detail without statistical analysis and also reported that antibiotics therapy alone was safe and effective in spondylodiscitis without complications [34]. In contrast to these studies, Nastro et al. offered the patients to choose between a TLSO for 3–4 months and bridging percutaneous pedicle screw constructs followed by a soft brace for 4 weeks [43]. They analyzed the differences in the clinical outcome between these groups and report a lower VAS, higher SG-36, and higher EQ-5D in the first 3–6 months in the surgical treatment group. However, no statistically significant differences were found after 9 months [43] (Table 7).
Microorganism-specific treatment
Five studies focused on microorganism-specific antibiotic treatment [28, 36, 44–46]. Jensen, Loible, and Mulleman et al. described retrospective cohorts of spondylodiscitis patients and report a higher complication rate in S. aureus infections and a higher risk of concomitant endocarditis in enterococcal spondylodiscitis [28, 36, 44]. As a result, Jensen et al. advised a minimum of 8 weeks of antibiotic treatment for S. aureus spondylodiscitis. The prospective study by Park et al. compared methicillin-resistant S. aureus (MRSA) with methicillin-susceptible S. aureus (MSSA) [45]. A higher relapse rate was found in the MRSA patients and again a longer antibiotic treatment was suggested [45]. Rangaraj et al. retrospectively analyzed the efficiency of vancomycin and Daptomycin in the treatment of MRSA spondylodiscitis [46]. The relapse rate in the Daptomycin groups was 3 %, whereas 30 % relapse was found in the vancomycin group [46] (Table 8).
Treatment of HIV and IVDU patients
Two studies focused on the treatment of specific patient groups [33, 47]. Sobottke et al. retrospectively compared surgical with systemic antibiotics therapy alone in HIV patients and found no statistically increased complication or relapse rate in the surgically treated patients [33]. Wang et al. prospectively compared the outcome of spondylodiscitis in intravenous drug users (IVDUs) and non-IVDUs [47]. A higher percentage of hardware failure and a longer hospital stay was found in de IVDU groups; however, a higher in-hospital mortality was found in the non-IVDU group (Table 9).
Discussion
A total of 25 studies were included in this systematic review of English language literature comprising data from 2407 patients with pyogenic spondylodiscitis. All studies described the outcome of conservatively or surgically treated pyogenic spondylodiscitis. Only two RCTS and three prospective studies were found. The quality of the evidence was high in just one study, moderate in four studies, and very low in the remaining 20 retrospective studies. Based on the finding of the studies focusing on systemic antibiotics treatment of pyogenic spondylodiscitis, treatment of 6 weeks results in a similar mortality, relapse, and failure rate compared to longer treatment duration [4, 30, 31, 35, 37, 38]. The nine articles that described the outcome of surgical treatment strategies show that a large variety of surgical techniques can successfully treat spondylodiscitis, whereas the less elaborate and less invasive approaches appear to have a better functional outcome [16–18, 29, 32, 39–42]. So far, no additional long-term beneficial effect of surgical treatment could be shown in the studies comparing surgical versus conservative treatment [27, 34, 43]. However, we should consider that most of the surgical interventions were performed in cases with complications and/or inadequate response to a conservative approach and the groups are difficult to compare. If surgical intervention is chosen an isolated decompression procedure leads up to 43 % reoperation rates [27]. Concomitant surgical stabilization is associated with less complications and reoperations. The five microorganism-specific studies suggest at least 8 weeks of antibiotic treatment for S. aureus spondylodiscitis and Daptomycin for the treatment of MRSA spondylodiscitis [28, 36, 44–46]. The two studies focusing on immunosuppressed patients described that surgical treatment in HIV patients is not associated with more complications, while early hardware failure was more common in surgically treated IVDUs [33, 47].
Strength and limitations
This is the first systematic literature review on the outcome of the treatment of pyogenic spondylodiscitis comprising all spinal regions. A literature review regarding the treatment of cervical spondylodiscitis had been published previously [48]. In order to obtain an evidence-based assessment of the literature on this subject, this review was performed in adherence to the PRISMA statement and used the GRADE approach. We limited our search to articles published in English, since our knowledge of other languages was not sufficient to guarantee a valid critical appraisal. This could have introduced a selection bias in our literature review. Moreover, the articles published before 2000 were not systematically searched and were only screened by reference checking of the included articles and recent relevant reviews. This theoretically could introduce a selection bias to our systematic literature review. However, the literature published before 2000 predominantly concerns infections caused by tuberculosis. Therefore, we have chosen a more pragmatic approach as described in the “Method” section. Furthermore, this review focused on clinical decision-making and therefore case reports and small case series were not included. The main focus of our search strategy was on studies that compared different treatment strategies, which might also have introduced selection bias in our search.
Next to the limitations induced by our search methodology, the characteristics of the included studies also introduce their own specific bias into this review. As a result of our aim to review the outcome of both conservative and surgical treatment of pyogenic spondylodiscitis, we have created a very heterogenic study population. Moreover, this heterogeneity is also seen in the separate study populations of the included articles. Fifteen of the included studies contain a minority of patients that no completely meet our inclusion criteria [4, 16–18, 27–36, 44]. Ten studies include a small number patients with tuberculosis and postoperative infections representing, respectively, 3.1 and 2.2 % of the included patient in this review [16–18, 27–33]. Moreover seven studies included children and adolescents representing 1.3 % of the study population of this review [4, 27, 32, 34–36, 44]. The patients with spondylodiscitis caused by tuberculosis could have negatively influenced the clinical outcome since tuberculosis has been suggested to have higher treatment failure rates, higher risk of deformity, and more often need surgical treatment [49, 50]. On the other hand, childhood and postoperative spondylodiscitis are known to have a more favorable prognosis and could have positively influenced outcome results [2, 51, 52]. Final limitation of our current review is the quality of the available evidence, 80 % of the include studies have a very low level of evidence resulting in a weak level of recommendation.
Clinical implications
Conservative treatment is indicated for the majority of pyogenic spondylodiscitis patients [3, 27, 34]. One of the most important findings of this review is that 6 weeks of antibiotic treatment appear to have a similar mortality, relapse, and failure rate as 12-week treatment [31, 38]. This was shown by the RCT of Bernard et al. and the retrospective study of Roblot et al. of which the RCT was evaluated as a strong level of recommendation according the GRADE criteria. Contrastingly, prolonged antibiotic treatment has been suggested by other studies for spondylodiscitis caused by S. aureus and MRSA with a weak and strong level of recommendation, respectively [6, 30, 45]. Nevertheless, these studies focusing on S. aureus report similar mortality, relapse, and failure rates as Bernard and Roblot et al. [30, 31, 38, 44, 45]. Moreover, S. aureus was also the most predominant microorganism in the studies by Bernard and Roblot et al. (41 and 36 % respectively [31, 38]). Since reduction of antibiotic treatment duration in uncomplicated pyogenic spondylodiscitis, defined as spondylodicitis without epidural abscess, deformity or neurological deficit does not lead to an increase in mortality, relapse, and failure rate, treatment duration can safely be reduced to 6 weeks (2 weeks intravenous, followed by 4 weeks oral). Due to the contrasting findings regarding S. aureus and MRSA, further research is required to determine the length of antibiotic treatment for these specific microorganisms.
Other conservative treatment options such as bed rest and TLSO have not been investigated in detail. Therefore, we are unable to give a level of recommendation regarding this subject. However, a pragmatic approach with bed rest until pain and infection parameters are decreasing and start of mobilization with a TLSO as tolerated appear to be a generally accepted strategy [3, 10, 11, 33–35, 43, 53].
The indications of surgical treatment have been clearly described in literature: compression of neurological structures, spinal instability, spinal deformity, and failure of conservative treatment [1–3, 10, 11]. This postulation was further underscored by the included articles in this review, although with a low level of recommendation [27, 34, 43]. Moreover, there are also some indications that surgical treatment in uncomplicated spondylodiscitis could result in faster recovery, faster mobilization and a better short-term quality of life when compared to conservative treatment. However, this is only supported by a low level of recommendation without significant clinical differences after 9 months [43, 54].
Currently, many different surgical treatment strategies are being used for the treatment of pyogenic spondylodiscitis [1–3, 10, 11]. Historically anterior debridement combined with posterior stabilization has been the golden standard in the surgical treatment of spondylodiscitis [2]. However, since this is an elaborate procedure which can be undesirable in critically ill patients, many different less invasive procedures have been developed [16, 17, 29, 39, 40, 55]. Among these less invasive procedures are solely anterior or posterior procedures, combined procedures with percutaneous posterior stabilization, and percutaneous drainage [16, 17, 29, 39, 40, 55]. The RCT by Lindhardt et al. and the prospective study by Si et al. demonstrated that an isolated anterior approach results in a better clinical outcome (SF36, Oswestry, ODI, and VAS) than a combined anterior–posterior procedure [29, 39]. These two studies were evaluated as a strong level of recommendation according the GRADE criteria. Although prospective and of adequate quality, it must be mentioned that these two studies only comprise a total of 50 patients. Isolated posterior approaches demonstrated to have similar mortality, relapse, and failure rates as the combined procedures; however, level of recommendation of these studies was evaluated as weak [16, 17, 55]. Percutaneous posterior methods have especially been advocated for patients in a poor general condition [16, 56]. Based on the literature in this review, there seems to be a trend to less elaborate procedures with similar mortality, relapse, and failures rates compared to the traditional methods while clinical outcome appears to be better. Solely percutaneous posterior procedures could be a good alternative in patients with multiple morbidities [56, 57]. Surgical treatment of spondylodiscitis could be more complex in specific patient groups, for example, in IVDUs where early hardware failure and surgical site infections were more common [47]. Interestingly surgical treatment in HIV patients is not related with higher complication rates [33]. This might be explained by the fact that outcome of spondylitis in this patient group is much more related to the HIV disease severity than the chosen treatment strategy [58].
As one of the study characteristics we reported, the percentage of positive cultures for each included study. The percentage of positive cultures ranges from 42–100 % in the current review. The assumption that identification of the causative microorganism leads to more effective treatment is well established; however, there are no studies available to support this hypothesis [2, 9, 59]. On the contrary, the recent study by Kim et al. showed a more favorable outcome in empirical treated patient versus patients with microbiologically confirmed spondylodiscitis. Kim et al. suggest that the patients with culture negative spondylodiscitis often have a less severe infection and therefore a more better outcome [59]. In our review, no difference in outcome is seen between the studies with a low percentage of positive cultures versus studies with a high percentage.
Future research
At this moment, there is insufficient high-quality data available to create a complete evidence-based guideline with strong recommendations for the treatment of pyogenic spondylodiscitis. More prospective and preferably randomized studies are required. Besides an increase in data quality, a change in research focus is also desirable. Although only 10–20 % of the patients with pyogenic spondylodiscitis may require a surgical intervention, this is the largest treatment group reported in the current review (9 out of 25 articles). There seems to be a strong publication bias in favor of surgical treatment. This phenomenon was also observed in the 16 abstracts of scientific conferences found in our literature search [8, 54–56, 60–71]. Nine of the 16 abstracts are focusing purely on surgical strategies, whereas only three on the antibiotics treatment were found. Since the vast majority of the spondylodiscitis patients are treated conservatively more high-quality research regarding the conservative treatment of spondylodiscitis is required. Moreover many fundamental aspects of the conservative treatment of spondylodiscitis are still unknown and require further research. For example, a randomized trial regarding bed rest or TLSO treatment could be a major contribution to the treatment of pyogenic spondylodiscitis.
Moreover, the current systematic literature review is limited on the outcome of different treatment strategies, whereas it has been well know that patient characteristic also significantly influence the outcome of spondylodiscitis [58, 72, 73]. A prognostic systematic review regarding the effect of patient characteristic on the outcome of spondylodiscitis could be a valuable addition to the available literature.
Conclusion
The current systematic literature review summarizes the outcome of conservatively and surgically treated pyogenic spondylodiscitis and assesses the quality of the available evidence. Unfortunately the majority of the included studies had a very low level of evidence. However, there is a strong level of recommendation for 6 weeks of systemic antibiotics treatment in uncomplicated pyogenic spondylodiscitis, although this has only been shown by one RCT. If surgical treatment is indicated, a prospective comparative study and a RCT have shown, with a strong level of recommendation, that an isolated anterior approach could result in a better clinical outcome compared to more extensive combined anterior–posterior procedures. Emerging less invasive surgical techniques should be studied more extensively in order to gather more robust data.
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The authors would like to thank Harm Wouter Snippe from the Netherlands Institute for Health Services for his help with the study selection.
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Rutges, J.P.H.J., Kempen, D.H., van Dijk, M. et al. Outcome of conservative and surgical treatment of pyogenic spondylodiscitis: a systematic literature review. Eur Spine J 25, 983–999 (2016). https://doi.org/10.1007/s00586-015-4318-y
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DOI: https://doi.org/10.1007/s00586-015-4318-y