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Implication of tumor necrosis factor alpha receptor 1 and hexosaminidase: relationship to pathogenesis of liver diseases

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Abstract

Liver disease is the main cause of morbidity and mortality worldwide. The spectrum of the disease ranged from fatty liver to hepatic inflammation, necrosis, progressive fibrosis, and hepatocellular carcinoma. We evaluated the serum levels of soluble tumor necrosis factor alpha receptor 1, total B-hexosaminidase and its isoenzymes Hex A and B activities, and nitric oxide in patients with liver diseases and their association with aminotransferase level. Seventy patients and 12 healthy subjects were recruited. Patients were divided into three groups: chronic hepatitis group (20 patients), liver cirrhosis group (30 patients), and malignant liver group (20 patients). Serum levels of soluble tumor necrosis factor alpha receptor 1, total B-hexosaminidase and its isoenzymes Hex A and B activities, and nitric oxide were measured. Serum levels of soluble tumor necrosis factor alpha receptor 1, total B-hexosaminidase activity, and nitric oxide were significantly higher in the liver disease patients. Serum levels of isoenzymes Hex A and B were significantly higher in malignant liver patients. Total B-hexosaminidase and its isoenzyme Hex A activity levels were significantly higher in positive HBsAg and positive anti-HCV patients. Serum levels of soluble tumor necrosis factor alpha receptor 1 were positively correlated with aminotransferase level. Taken together, these findings suggested that these biochemical indices might reflect ongoing disease activity and played an important role in the pathophysiology of liver diseases.

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Authors and Affiliations

  1. Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt

    N. K. Idriss & M. M. Zakhary

  2. Department of Medical Physiology, Faculty of Medicine, Assiut University, Assiut, Egypt

    Hayam G. Sayyed

  3. Department of Anaesthesiology, Faculty of Medicine, Assiut University, Assiut, Egypt

    Sherif Sayed

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  1. N. K. Idriss
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  2. Hayam G. Sayyed
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  3. M. M. Zakhary
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  4. Sherif Sayed
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Correspondence to N. K. Idriss.

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Idriss, N.K., Sayyed, H.G., Zakhary, M.M. et al. Implication of tumor necrosis factor alpha receptor 1 and hexosaminidase: relationship to pathogenesis of liver diseases. Comp Clin Pathol 23, 1095–1102 (2014). https://doi.org/10.1007/s00580-013-1747-z

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  • DOI: https://doi.org/10.1007/s00580-013-1747-z

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