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MEMS based cantilever biosensors for cancer detection using potential bio-markers present in VOCs: a survey

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Abstract

The biosensors are being used for detection of various dangerous biomarkers present in water, air and human body, etc. Invasive and non-invasive methods are discussed. In non-invasive method, the early detection of any disease involves detection of available biomarkers in exhaled breath at ppb level. The biomarkers for different disease are presented here and the methods involved are also provided. This study mainly focuses on systematic review of various cancer disease with biomarkers and also provides the comparative review of different traditional biosensors such as FET based biosensor with micro–electro-mechanical systems (MEMS) based Biosensors capable of detecting biomarkers even at ppb level in exhaled breath. This study also concludes that the cantilever or array of cantilever-based biosensors is simple and very precise for early detection of cancer disease. Cantilever surfaces with pores are highly desirable since it increases sensitivity of biosensors.

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  1. Department of Electronics and Communication Engineering, Rajiv Gandhi University (A Central University), Itanagar, 791112, India

    Kurmendra

  2. Department of Electronics and Communication Engineering, North Eastern Regional Institute of Science and Technology, Itanagar, 791110, India

    Rajesh Kumar

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Kurmendra, Kumar, R. MEMS based cantilever biosensors for cancer detection using potential bio-markers present in VOCs: a survey. Microsyst Technol 25, 3253–3267 (2019). https://doi.org/10.1007/s00542-019-04326-1

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