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Dezocine pretreatment prevents myoclonus induced by etomidate: a randomized, double-blinded controlled trial

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Abstract

The aim of this randomized, double-blind, placebo-controlled clinical trial was to evaluate the effects of dezocine on the incidence and severity of myoclonus induced by etomidate. Patients (108) were randomly assigned to one of two groups to receive either 0.1 mg kg−1 of dezocine (n = 54; Group D) or saline (n = 54; Group S) intravenously 1 min before 0.3 mg kg−1 etomidate was given. The occurrence and severity (observational score of 0–3) of myoclonus was assessed for 2 min after administration of etomidate. The incidence and the intensity of myoclonus were significantly lower in Group D (0 %) than in Group S (75.9 %) (P < 0.01), and all patients showed stable cardiovascular profiles. The results suggest that infusion of 0.1 mg kg−1 dezocine 1 min before etomidate administration is effective for suppressing myoclonus induced by etomidate during induction of general anesthesia without significant side-effects.

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Conflict of interest

None of the authors has any conflict of interest.

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Authors and Affiliations

  1. Department of Anesthesiology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, China

    Liang He, Ying Ding & Huiyu Chen

  2. Department of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China

    Yanning Qian

  3. Key Laboratory of Modern Toxicology (Ministry of Education), School of Public Health, Nanjing Medical University, No. 818 East Tianyuan Road, Nanjing, 211166, Jiangsu, China

    Zhong Li

Authors
  1. Liang He
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  2. Ying Ding
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  3. Huiyu Chen
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  4. Yanning Qian
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  5. Zhong Li
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Corresponding author

Correspondence to Zhong Li.

Additional information

Trial registration: Chinese Clinical Trial Registry (ID: ChiCTR-PRC-13003152). The registration information can be found on the following website: http://apps.who.int/trialsearch/Trial.aspx?TrialID=ChiCTR-PRC-13003152.

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He, L., Ding, Y., Chen, H. et al. Dezocine pretreatment prevents myoclonus induced by etomidate: a randomized, double-blinded controlled trial. J Anesth 29, 143–145 (2015). https://doi.org/10.1007/s00540-014-1854-2

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  • DOI: https://doi.org/10.1007/s00540-014-1854-2

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