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Not all placebos are the same: a debate on the ethics of placebo use in clinical trials versus clinical practice

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References

  1. H Brody (1995) Placebo WT Reich (Eds) Encyclopedia of bioethics Macmillan New York 1951–1953

    Google Scholar 

  2. World Medical Association (2000) Declaration of Helsinki. Ethical principles for medical research involving human subjects. http://www.wma.net/e/ethicsunit/helsinki.htm

  3. B Freedman KC Glass C Weijer (1996) ArticleTitlePlacebo orthodoxy in clinical research J Law Med Ethics 24 243–259 Occurrence Handle9069851 Occurrence Handle1:STN:280:DyaK2s3it12ltA%3D%3D

    PubMed  CAS  Google Scholar 

  4. KJ Rothman KB Michels (1994) ArticleTitleThe continuing unethical use of placebo controls N Engl J Med 331 394–398 Occurrence Handle8028622 Occurrence Handle10.1056/NEJM199408113310611 Occurrence Handle1:STN:280:DyaK2czgtFemtw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  5. P Tugwell C Bombardier M Gent et al. (1990) ArticleTitleLow dose cyclosporine versus placebo in patients with rheumatoid arthritis Lancet 335 1051–1055 Occurrence Handle1970370 Occurrence Handle10.1016/0140-6736(90)92630-Z Occurrence Handle1:STN:280:DyaK3c3jtV2nsw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  6. A Kiev (1992) ArticleTitleA double blind, placebo controlled study of paroxetine in depressed out-patients J Clin Psychiatry 53 IssueIDSuppl 27–29 Occurrence Handle1531818

    PubMed  Google Scholar 

  7. TM Beck AA Ciociola SE Jones WH Harvey NS Tchekmedyian A Chang D Galvin NE Hart (1993) ArticleTitleEfficacy of oral ondansetron in the prevention of emesis in outpatients receiving cyclophsphamide based chemotherapy Ann Int Med 118 407–413 Occurrence Handle8439113 Occurrence Handle1:STN:280:DyaK3s7nsFOruw%3D%3D

    PubMed  CAS  Google Scholar 

  8. AA Carr PB Bottini LM Prisnat LD Fisher JG Devane DE O'Brien RB Rhoades (1991) ArticleTitleOnce daily verapamil in the treatment of mild to moderate hypertension. A double blind placebo controlled dose ranging study J Clin Pharmacol 31 144–150 Occurrence Handle2010560 Occurrence Handle1:STN:280:DyaK3M7osFKnsg%3D%3D

    PubMed  CAS  Google Scholar 

  9. KB Michels KJ Rothman (2003) ArticleTitleUpdate on unethical use of placebos in randomized trials Bioethics 17 188–204 Occurrence Handle12812185 Occurrence Handle10.1111/1467-8519.00332

    Article  PubMed  Google Scholar 

  10. B Keating (2004) ArticleTitleL'éthique de la recherche et l'usage du placebo. Un état de la question au Canada Med Sci 20 118–125

    Google Scholar 

  11. RV Carlson KM Boyd DJ Webb (2004) ArticleTitleThe revision of the Declaration of Helsinki: past, present and future Br J Clin Pharmacol 57 695–713 Occurrence Handle15151515 Occurrence Handle10.1111/j.1365-2125.2004.02103.x

    Article  PubMed  Google Scholar 

  12. M Amanzino F Benedetti (1999) ArticleTitleNeuropharmacological dissection of placebo analgesia: expectation-activated opioid systems versus conditioning-activated specific subsystems J Neurosci 19 484–494

    Google Scholar 

  13. HS Mayberg JA Silva SK Brannan JL Tekell RK Mahurin S McGinnis PA Jerabek (2002) ArticleTitleThe functional neuroanatomy of the placebo effect Am J Psychiatry 159 728–737 Occurrence Handle11986125 Occurrence Handle10.1176/appi.ajp.159.5.728

    Article  PubMed  Google Scholar 

  14. P Petroviç E Kalso KM Petersson M Ingvar (2002) ArticleTitlePlacebo and opioid analgesia imaging: a shared neuronal network Science 295 1737–1740 Occurrence Handle11834781 Occurrence Handle10.1126/science.1067176

    Article  PubMed  Google Scholar 

  15. T Yanagawa T Tango Y Hiejima (1994) ArticleTitleMantel-Haenzel type tests for testing equivalence or more than equivalence in comparative clinical trials Biometrics 50 859–864 Occurrence Handle7981407 Occurrence Handle10.2307/2532800 Occurrence Handle1:STN:280:DyaK2M%2Fnt1agug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  16. S Horng FG Miller (2002) ArticleTitleIs placebo surgery unethical? N Engl J Med 347 137–139 Occurrence Handle12110744 Occurrence Handle10.1056/NEJMsb021025

    Article  PubMed  Google Scholar 

  17. LA Cobb GI Thomas DH Dillard KA Merendino RA Bruce (1959) ArticleTitleAn evaluation of internal mammary artery ligation by a double blind technique N Engl J Med 260 1115–1118 Occurrence Handle13657350 Occurrence Handle1:STN:280:DyaG1M%2FoslSitQ%3D%3D Occurrence Handle10.1056/NEJM195905282602204

    Article  PubMed  CAS  Google Scholar 

  18. EG Dimond CF Kittle JE Crocket (1960) ArticleTitleComparison of internal mammary artery ligation and sham operation for angina pectoris Am J Cardiol 5 483–486 Occurrence Handle13816818 Occurrence Handle10.1016/0002-9149(60)90105-3 Occurrence Handle1:STN:280:DyaF3c7jslaksA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  19. JB Moseley K O'Malley NJ Petersen TJ Menke BA Brody DH Kuykendall JC Hollingsworth CM Ashton NP Wray (2002) ArticleTitleA controlled trial of arthroscopic surgery for osteoarthritis of the knee N Engl J Med 347 81–88 Occurrence Handle12110735 Occurrence Handle10.1056/NEJMoa013259

    Article  PubMed  Google Scholar 

  20. RJ Temple (1997) ArticleTitleWhen are clinical trials of a given agent versus placebo no longer appropriate or feasible? Control Clin Trials 18 613–620 Occurrence Handle9408723 Occurrence Handle10.1016/S0197-2456(97)00058-5 Occurrence Handle1:STN:280:DyaK1c%2FntlShsw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  21. MA Konstam I Pina J Lindenfeld M Packer (2003) ArticleTitleA device is not a drug J Cardiac Failure 9 155–157 Occurrence Handle10.1054/jcaf.2003.45

    Article  Google Scholar 

  22. R Macklin (1999) ArticleTitleThe ethical problems with sham surgery in clinical research N Engl J Med 341 992–996 Occurrence Handle10498498 Occurrence Handle10.1056/NEJM199909233411312 Occurrence Handle1:STN:280:DyaK1Mvht1Srtw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  23. S Horng FG Miller (2003) ArticleTitleEthical framework for the use of sham procedures in clinical trials Crit Care Med 31 S126–S130 Occurrence Handle12626957 Occurrence Handle10.1097/01.CCM.0000054906.49187.67

    Article  PubMed  Google Scholar 

  24. Ricœur P (2001) Les trois niveaux du jugement médical. Esprit, pp. 21–33

  25. BA Rich (2003) ArticleTitleA placebo for pain: a medico-legal case analysis Pain Medicine 4 366–372 Occurrence Handle14750916 Occurrence Handle10.1111/j.1526-4637.2003.03046.x

    Article  PubMed  Google Scholar 

  26. J Hill (2003) ArticleTitlePlacebo in clinical care: for whose pleasure? Lancet 362 254 Occurrence Handle12885507 Occurrence Handle10.1016/S0140-6736(03)13940-2

    Article  PubMed  Google Scholar 

  27. L Benaroyo (2004) ArticleTitleSoin, confiance et disponibilité Ethique et Santé 1 60–63

    Google Scholar 

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Authors and Affiliations

  1. Postoperative and Interventional Pain Program, Department of Anesthesiology, Pharmacology and Surgical Intensive Care, Geneva University Hospital, 1211 Geneva 14, Geneva, Switzerland

    Alex Cahana

  2. Center for the Study of Ethics, Faculty of Theology, University of Lausanne, Lausanne, Switzerland

    Simone Romagnioli

Authors
  1. Alex Cahana
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  2. Simone Romagnioli
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Cahana, A., Romagnioli, S. Not all placebos are the same: a debate on the ethics of placebo use in clinical trials versus clinical practice. J Anesth 21, 102–105 (2007). https://doi.org/10.1007/s00540-006-0440-7

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  • DOI: https://doi.org/10.1007/s00540-006-0440-7

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