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Preoperative administration of intravenous flurbiprofen axetil reduces postoperative pain for spinal fusion surgery

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Abstract

Purpose

The aim of the study was to investigate postoperative analgesia and the opioid-sparing effect of the preoperative administration of intravenous flurbiprofen axetil in patients undergoing spinal fusion surgery.

Methods

Thirty-six patients were randomly allocated into one of three groups. Group A received preoperative flurbiprofen axetil, 1 mg·kg−1. Group B received postoperative flurbiprofen axetil, 1 mg·kg−1. Group C received a placebo. All groups were given a standardized anesthesia and intravenous morphine via a patient-controlled analgesia device for postoperative analgesia. The pain score was evaluated by a visual analog scale (VAS) at 0 (T0), 1 (T1), 2 (T2), 6 (T3), 12 (T4), and 24 (T5) h after surgery, and the morphine requirement was recorded during the study period.

Results

VAS in group A was significantly lower than that in group B at T0 and T1. VAS in group A was significantly lower than that in group C throughout the time course after surgery. Postoperative morphine consumption in group A was significantly lower than that in groups B and C at T0 to T3.

Conclusion

As compared with postoperative administration, preoperative administration of intravenous flurbiprofen axetil provides better postoperative analgesia and an opioid-sparing effect in patients undergoing spinal fusion surgery under general anesthesia.

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Authors and Affiliations

  1. Department of Anesthesia, Nagasaki Rosai Hospital, 2-12-5 Setogoshi, Sasebo, 857-0134, Japan

    Kazunori Yamashita, Makoto Fukusaki, Yuko Ando, Arihiro Fujinaga, Takahiro Tanabe & Yoshiaki Terao

  2. Division of Anesthesiology, Department of Translational Medical Science, Nagasaki University School of Medicine, Nagasaki, Japan

    Koji Sumikawa

Authors
  1. Kazunori Yamashita
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  2. Makoto Fukusaki
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  3. Yuko Ando
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  4. Arihiro Fujinaga
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  5. Takahiro Tanabe
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  6. Yoshiaki Terao
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  7. Koji Sumikawa
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Yamashita, K., Fukusaki, M., Ando, Y. et al. Preoperative administration of intravenous flurbiprofen axetil reduces postoperative pain for spinal fusion surgery. J Anesth 20, 92–95 (2006). https://doi.org/10.1007/s00540-006-0389-6

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  • DOI: https://doi.org/10.1007/s00540-006-0389-6

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