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Trends in incidence of small bowel cancer according to histology: a population-based study

  • Original Article—Alimentary Tract
  • Published:
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Abstract

Background

Small bowel cancer is not a single entity. Population-based studies taking into account histological diversity are scarce. The aim of this study was to report on their trends in incidence by histology in France over the past 20 years.

Methods

All patients with a small bowel cancer diagnosed in 15 French administrative areas covered by a registry from the network of French cancer registries (FRANCIM) were included. Age-standardized incidence rates were estimated using the world standard population. Incidence rates were calculated by gender, age group, histology, and 5-year period.

Results

The overall age-standardized incidence rates were 1.46/100,000 inhabitants in men and 0.9/100,000 inhabitants in women. Adenocarcinoma was the most common histological type (38%), followed by neuroendocrine tumors (35%), lymphoma (15%) and sarcoma (12%). Age at diagnosis and tumor location differed between adenocarcinoma and neuroendocrine tumors. The incidence of all four tumor types increased significantly over the 20-year period, with the exception of lymphoma in men. The annual percentage change for neuroendocrine tumors was 3.89% in men and 3.61% in women; for sarcoma, it was 3.38% and 4.08%, respectively. The incidence of adenocarcinoma and lymphoma also increased in women with an annual percentage change of 3.05% and 3.32%, respectively.

Conclusion

Small bowel cancer incidence has increased over time. This increase occurred with different amplitudes and patterns in the four major histological types. The improvement in imaging techniques could partly explain this increase. It is necessary to determine whether predisposing conditions may contribute to this change.

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Acknowledgements

Zoe Uhry (Biostatistique-Bioinformatique, Hospices Civils de Lyon, F-69003, Département des Maladies, Non Transmissible et des Traumatismes, Santé Publique France, France) for maintaining and extracting data from the common FRANCIM database.

Author information

Authors and Affiliations

  1. Digestive Cancer Registry of Burgundy, Dijon, France

    Anne-Marie Bouvier, Valérie Jooste & Antoine Drouillard

  2. LNC UMR1231 EPICAD, Dijon, France

    Anne-Marie Bouvier, Valérie Jooste & Antoine Drouillard

  3. University of Bourgogne Franche-Comté, UFR des sciences de santé, Dijon, France

    Anne-Marie Bouvier, Valérie Jooste & Antoine Drouillard

  4. FRANCIM (French Network of cancer registries), Toulouse, France

    Anne-Marie Bouvier, Michel Robaszkiewicz, Valérie Jooste, Mélanie Cariou, Véronique Bouvier & Jean-Baptiste Nousbaum

  5. Digestive Cancer Registry of Finistère, EA 7479 SPURBO, University Hospital, Brest, France

    Michel Robaszkiewicz, Mélanie Cariou & Jean-Baptiste Nousbaum

  6. Department of Hepato-Gastroenterology, University Hospital La Cavale Blanche, Brest, France

    Michel Robaszkiewicz & Jean-Baptiste Nousbaum

  7. Digestive Tumour Registry of Calvados, Pôle recherche CHU Caen Normandie, INSERM-UCN 1086, Centre François Baclesse, Caen, France

    Véronique Bouvier

  8. Dijon University Hospital, Dijon, France

    Anne-Marie Bouvier, Valérie Jooste & Antoine Drouillard

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  1. Anne-Marie Bouvier
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  2. Michel Robaszkiewicz
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  4. Mélanie Cariou
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Consortia

The French Network of Cancer Registries (FRANCIM)

  • Brice Amadeo
  • , Patrick Arveux
  • , Isabelle Baldi
  • , Simona Bara
  • , Anne-Marie Bouvier
  • , Véronique Bouvier
  • , Jacqueline Clavel
  • , Marc Colonna
  • , Gaëlle Coureau
  • , Anne Cowppli-Bony
  • , Sandrine Dabakuyo
  • , Tania Dalmeida
  • , Laetitia Daubisse-Marliac
  • , Gautier Defossez
  • , Patricia Delafosse
  • , Jacqueline Deloumeaux
  • , Pascale Grosclaude
  • , Anne-Valérie Guizard
  • , Clarisse Joachim
  • , Valérie Jooste
  • , Brigitte Lacour
  • , Bénédicte Lapôtre-Ledoux
  • , Guy Launoy
  • , Emilie Marrer
  • , Marc Maynadié
  • , Florence Molinié
  • , Alain Monnereau
  • , Jean-Baptiste Nousbaum
  • , Juliette Plenet
  • , Sandrine Plouvier
  • , Camille Pouchieu
  • , Michel Robaszkiewicz
  • , Claire Schvartz
  • , Brigitte Trétarre
  • , Xavier Troussard
  • , Michel Velten
  •  & Anne-Sophie Woronoff

Corresponding author

Correspondence to Anne-Marie Bouvier.

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Bouvier, AM., Robaszkiewicz, M., Jooste, V. et al. Trends in incidence of small bowel cancer according to histology: a population-based study. J Gastroenterol 55, 181–188 (2020). https://doi.org/10.1007/s00535-019-01636-z

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  • DOI: https://doi.org/10.1007/s00535-019-01636-z

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