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The ability of a novel blue laser imaging system for the diagnosis of invasion depth of colorectal neoplasms

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Abstract

Background

Fujifilm has developed a novel endoscope system with two kinds of lasers that enables us to allow narrow-band light observation with blue laser imaging (BLI). The aim of this study was to evaluate BLI magnification in comparison with narrow-band imaging (NBI) magnification for the diagnosis of colorectal neoplasms.

Methods

This was a multicenter open study. A total of 104 colorectal neoplasms were examined with BLI and NBI magnifications in Kyoto Prefectural University of Medicine and Fukuoka University Chikushi Hospital. Vascular and surface patterns of tumors under BLI magnification were compared with those under NBI magnification, using a published NBI classification. The main outcome was the correlation between the NBI classification diagnosed by BLI or NBI magnification and the histopathological analyses.

Results

Sixty-two cases of adenoma, 34 cases of intramucosal cancer and shallowly invaded submucosal cancer, and eight cases of deeply invaded submucosal cancer were diagnosed. The diagnostic accuracy of BLI magnification in the NBI classification was 74.0 % (77/104), similar to that of NBI magnification (77.8 %). The consistency rate between BLI and NBI magnification in the NBI classification was 74.0 %. Concerning image evaluation, the interobserver variability of two expert endoscopists (N.Y. and T.H.) in BLI magnification was κ = 0.863. On the other hand, the intraobserver variability of the two endoscopists was κ = 0.893 (N.Y.) and 0.851 (T.H.).

Conclusions

BLI magnification by laser source could predict histopathological diagnosis and invasion depth of colorectal neoplasms. The diagnostic effectiveness of this method was similar to that of NBI magnification.

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Acknowledgments

We thank all members of the Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, for helping with this study, and all members of the Department of Gastroenterology, Fukuoka University Chikushi Hospital. We thank Dr. Hironori Yamamoto for making the study design. We also thank Kubo Masahiro and all other members who assisted in all procedures related to the Fujifilm LASEREO system.

Conflict of interest

The Fujifilm Co. contributed to the BLI system in this study for free. Besides this, none of the authors have any conflict of interest or financial support to declare.

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Authors and Affiliations

  1. Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan

    Naohisa Yoshida, Yutaka Inada, Munehiro Kugai, Nobuaki Yagi & Yuji Naito

  2. Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka, Japan

    Takashi Hisabe, Fumihito Hirai, Kenshi Yao & Toshiyuki Matsui

  3. Department of Pathology, Fukuoka University Chikushi Hospital, Fukuoka, Japan

    Akinori Iwashita

  4. Department of Endoscopy, Hokkaido University Hospital, Hokkaido, Japan

    Mototsugu Kato

  5. Department of Surgical Pathology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Akio Yanagisawa

Authors
  1. Naohisa Yoshida
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  2. Takashi Hisabe
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  3. Yutaka Inada
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  4. Munehiro Kugai
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  5. Nobuaki Yagi
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  6. Fumihito Hirai
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  7. Kenshi Yao
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  8. Toshiyuki Matsui
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  9. Akinori Iwashita
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  10. Mototsugu Kato
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  11. Akio Yanagisawa
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  12. Yuji Naito
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Corresponding author

Correspondence to Naohisa Yoshida.

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Yoshida, N., Hisabe, T., Inada, Y. et al. The ability of a novel blue laser imaging system for the diagnosis of invasion depth of colorectal neoplasms. J Gastroenterol 49, 73–80 (2014). https://doi.org/10.1007/s00535-013-0772-7

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  • DOI: https://doi.org/10.1007/s00535-013-0772-7

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