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Prevalence of organic colonic lesions in patients meeting Rome III criteria for diagnosis of IBS: a prospective multi-center study utilizing colonoscopy

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Abstract

Background

It remains unknown whether the Rome III criteria can exclude organic colonic lesions prior to the diagnosis of irritable bowel syndrome (IBS). We evaluated the colonoscopy results of patients meeting the Rome III criteria for the diagnosis of IBS to determine the presence of organic colonic lesions.

Methods

This study was prospectively conducted at 17 centers in Japan. We enrolled 4528 patients who underwent diagnostic colonoscopy examinations. The diagnosis of IBS was evaluated by questionnaire results according to the Rome III criteria.

Results

We evaluated 4178 patients (350 were excluded because of incomplete data or previous colonic surgery), of whom 203 met the Rome III criteria (mean age 57.9 years; range 14–87 years) prior to the diagnostic colonoscopy examination. We identified organic colonic diseases in 21 of these 203 patients (10.3 %) , and these disease were also identified in 338 (8.5 %) of 3975 patients who did not fulfill the Rome III criteria. There were no differences in regard to the prevalence of organic colonic diseases between patients who did and did not fulfill the Rome III criteria.

Conclusions

The prevalence of organic colonic diseases in patients who met the Rome III criteria was at an acceptably low level, indicating that the Rome III criteria are adequately specific for the diagnosis of IBS without performing a colonoscopy examination.

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Conflicts of interest

The authors have no financial conflicts of interest to declare.

Author information

Authors and Affiliations

  1. Department of Internal Medicine II, Faculty of Medicine, Shimane University, 89-1, Enya-cho, Izumo, Shimane, Japan

    Shunji Ishihara & Yoshikazu Kinoshita

  2. Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University, Yonago, Japan

    Kazuo Yashima & Yoshikazu Murawaki

  3. Division of Gastroenterology, Matsue Red Cross Hospital, Matsue, Japan

    Yoshinori Kushiyama

  4. Izumi Gastrointestinal Clinic, Matsue, Japan

    Akio Izumi

  5. Division of Internal Medicine, Matsue Seikyo Hospital, Matsue, Japan

    Kousaku Kawashima

  6. Division of Gastroenterology, Shimane Prefectural Central Hospital, Izumo, Japan

    Hirofumi Fujishiro

  7. Division of Gastroenterology, Sanin Rosai Hospital, Yonago, Japan

    Haruhiko Kojo

  8. Division of Internal Medicine, Izumo City General Medical Center, Izumo, Japan

    Yoshinori Komazawa

  9. Division of Internal Medicine, Hakuai Hospital, Yonago, Japan

    Tetsuro Hamamoto

  10. Division of Internal Medicine, Yonago Medical Center, Yonago, Japan

    Tetsuo Yamamoto

  11. Division of Internal Medicine, Saiseikai Sakaiminato General Hospital, Sakaiminato, Japan

    Yuichiro Sasaki

  12. Division of Internal Medicine, Tottori Prefectural Central Hospital, Tottori, Japan

    Tatsunori Shimizu

  13. Division of Gastroenterology, Hamada Medical Center, Hamada, Japan

    Eiji Okamoto

  14. Division of Gastroenterology, Matsue City Hospital, Matsue, Japan

    Teiji Yoshimura

  15. Division of Internal Medicine, Masuda Medical Association Hospital, Masuda, Japan

    Koichiro Furuta

  16. Division of Internal Medicine, Tottori Prefectural Kousei Hospital, Kurayoshi, Japan

    Naoya Noguchi

  17. Division of Internal Medicine, Tottori Red Cross Hospital, Tottori, Japan

    Hisao Tanaka

Authors
  1. Shunji Ishihara
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  2. Kazuo Yashima
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  3. Yoshinori Kushiyama
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  4. Akio Izumi
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  5. Kousaku Kawashima
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  6. Hirofumi Fujishiro
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  7. Haruhiko Kojo
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  8. Yoshinori Komazawa
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  9. Tetsuro Hamamoto
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  10. Tetsuo Yamamoto
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  11. Yuichiro Sasaki
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  12. Tatsunori Shimizu
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  13. Eiji Okamoto
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  14. Teiji Yoshimura
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  15. Koichiro Furuta
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  16. Naoya Noguchi
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  17. Hisao Tanaka
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  18. Yoshikazu Murawaki
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  19. Yoshikazu Kinoshita
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Corresponding author

Correspondence to Shunji Ishihara.

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Ishihara, S., Yashima, K., Kushiyama, Y. et al. Prevalence of organic colonic lesions in patients meeting Rome III criteria for diagnosis of IBS: a prospective multi-center study utilizing colonoscopy. J Gastroenterol 47, 1084–1090 (2012). https://doi.org/10.1007/s00535-012-0573-4

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  • DOI: https://doi.org/10.1007/s00535-012-0573-4

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