Skip to main content
SpringerLink
Log in

Relation between histologic gastritis and gastric motility in Japanese patients with functional dyspepsia: evaluation by transabdominal ultrasonography

  • Alimmentary Tract
  • Published:
Journal of Gastroenterology Aims and scope Submit manuscript

Abstract

Background

Whether mucosal inflammation affects gastric motility in patients with functional dyspepsia (FD) is controversial. Few reports discuss gastric motility in relation to histologic gastritis. We examined the relation between gastric motility and histologic gastritis in Japanese patients with FD.

Methods

Subjects were 198 patients examined by ultrasonography (US) and endoscopic biopsy. Histologic gastritis scores were compared to three US gastric motility indices: the motility index (MI), gastroduodenal reflux index (RI), and gastric emptying rate (GER). In cases of gastritis with a high inflammation score (score 2–3), the macrophages in biopsy specimens were counted and compared to the motility indices.

Results

Of the 198 patients, 159 were Helicobacter pylori positive. Comparison of 39 age-and sex-matched H. pylori-positive and 39 H. pylori-negative patients showed that the MI was lower in H. pylori-positive patients (6.78 ± 2.17 vs. 7.63 ± 2.35, P < 0.05), and the RI was higher (5.64 ± 4.70 vs. 2.13 ± 2.58, P < 0.01). Among H. pylori-positive patients, US revealed a decreased MI in patients with a high inflammation score (score 2–3) in the antrum compared with the MI of those with a low inflammation score (score 0–1) (6.52 ± 2.38 vs. 7.82 ± 1.89, P < 0.01). The number of macrophages was not associated with motility indices in patients with a high inflammation score.

Conclusion

Histologic gastritis with severe inflammation may inhibit gastric motility.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Drossman DA. The functional gastrointestinal disorders and the Rome III process. Gastroenterology 2006;130:1377–1390.

    Article  PubMed  Google Scholar 

  2. Kusunoki H, Haruma K, Hata J, Tani H, Okamoto E, Sumii K, et al. Real-time ultrasonographic assessment of antroduodenal motility after ingestion of solid and liquid meals by patients with functional dyspepsia. J Gastroenterol Hepatol 2000;15:1022–1027.

    Article  PubMed  CAS  Google Scholar 

  3. Lee KJ, Kim JH, Cho SW. Dyspeptic symptoms associated with hypersensitivity to gastric distension induced by duodenal acidification. J Gastroenterol Hepatol 2006;21:515–520.

    Article  PubMed  Google Scholar 

  4. Kadouchi K, Tominaga K, Ochi M, Kawamura E, Sasaki E, Shiba M, et al. Interactions between the grading of gastric atrophy associated with Helicobacter pylori infection and the severity of clinical symptoms and delay in gastric emptying in patients with functional dyspepsia. Aliment Pharmacol Ther 2006;24:49–57.

    Article  Google Scholar 

  5. Shimatani T, Inoue M, Iwamoto K, Hyogo H, Yokozaki M, Saeki T, et al. Prevalence of Helicobacter pylori infection, endoscopic gastric findings and dyspeptic symptoms among a young Japanese population born in the 1970s. J Gastroenterol Hepatol 2005;20:1352–1357.

    Article  PubMed  Google Scholar 

  6. Suzuki H, Nishizawa T, Hibi T. Therapeutic strategies for functional dyspepsia and the introduction of the Rome III classification. J Gastroenterol 2006;41:513–523.

    Article  PubMed  Google Scholar 

  7. Kinoshita K, Horiguchi K, Fujisawa M, Kobirumaki F, Yamato S, Hori M, et al. Possible involvement of muscularis resident macrophages in impairment of interstitial cells of Cajal and myenteric nerve systems in rat models of TNBS-induced colitis. Histochem Cell Biol 2007;127:41–53.

    Article  PubMed  CAS  Google Scholar 

  8. Kinoshita K, Hori M, Fujisawa M, Sato K, Ohama T, Momotani E, et al. Role of TNF-alpha in muscularis inflammation and motility disorder in a TNBS-induced colitis model: clues from TNF-alpha-deficient mice. Neurogastroenterol Motil 2006;18:578–588.

    Article  PubMed  CAS  Google Scholar 

  9. Ohama T, Hori M, Sato K, Ozaki H, Karaki H. Chronic treatment with interleukin-1beta attenuates contractions by decreasing the activities of CPI-17 and MYPT-1 in intestinal smooth muscle. J Biol Chem 2003;278:48794–48804.

    Article  PubMed  CAS  Google Scholar 

  10. Okamoto E, Haruma K, Hata J, Tani H, Sumii K, Kajiyama G. Effects of octreotide, a somatostatin analogue, on gastric function evaluated by real-time ultrasonography. Aliment Pharmacol Ther 1997;11:177–184.

    Article  PubMed  CAS  Google Scholar 

  11. Fujimura J, Haruma K, Hata J, Yamanaka H, Sumii K, Kajiyama G. Quantitation of duodenogastric reflux and antral motility by color Doppler ultrasonography. Study in healthy volunteers and patients with gastric ulcer. Scand J Gastroenterol 1994;29:897–902.

    Article  PubMed  CAS  Google Scholar 

  12. Aoki S, Haruma K, Kusunoki H, Hata J, Hara M, Yoshida S, et al. Evaluation of gastric emptying measured with the 13C-octanoic acid breath test in patients with functional dyspepsia: comparison with ultrasonography. Scand J Gastroenterol 2002;37:662–666.

    Article  PubMed  CAS  Google Scholar 

  13. Takata S, Ito M, Yoshihara M, Tanaka S, Imagawa S, Haruma K, et al. Host factors contributing to the discovery of gastric cancer after successful eradication therapy of Helicobacter pylori: preliminary report. J Gastroenterol Hepatol 2007;22:571–576.

    Article  PubMed  Google Scholar 

  14. Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol 1996;20:1161–1181.

    Article  PubMed  CAS  Google Scholar 

  15. Hausken T, Odegaard S, Berstad A. Antroduodenal motility studied by real-time ultrasonography. Effect of enprostil. Gastroenterology 1991;100:59–63.

    PubMed  CAS  Google Scholar 

  16. Ohta M, Kitadai Y, Tanaka S, Yoshihara M, Yasui W, Mukaida N, et al. Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human gastric carcinomas. Int J Oncol 2003;22:773–778.

    PubMed  CAS  Google Scholar 

  17. Mizuta Y, Shikuwa S, Isomoto H, Mishima R, Akazawa Y, Masuda J, et al. Recent insights into digestive motility in functional dyspepsia. J Gastroenterol 2006;41:1025–1040.

    Article  PubMed  Google Scholar 

  18. Kamino D, Manabe N, Hata J, Haruma K, Tanaka S, Chayama K. Long-term ultrasonographic follow-up study of gastric motility in patients with functional dyspepsia. J Clin Biochem Nutr 2008;42:1–6.

    Article  Google Scholar 

  19. di Mario F, Stefani N, Bo ND, Rugge M, Pilotto A, Cavestro GM, et al. Natural course of functional dyspepsia after Helicobacter pylori eradication: a seven-year survey. Dig Dis Sci 2005;50:2286–2295.

    Article  PubMed  Google Scholar 

  20. Miyamoto M, Haruma K, Yoshihara M, Hiyama T, Sumioka M, Nishisaka T, et al. Nodular gastritis in adults is caused by Helicobacter pylori infection. Dig Dis Sci 2003;48:968–975.

    Article  PubMed  Google Scholar 

  21. Thor P, Lorens K, Tabor S, Herman R, Konturek JW, Konturek SJ. Dysfunction in gastric myoelectric and motor activity in Helicobacter pylori positive gastritis patients with non-ulcer dyspepsia. J Physiol Pharmacol 1996;47:469–476.

    PubMed  CAS  Google Scholar 

  22. Stanghellini V, Tosetti C, Paternicó A, Barbara G, Morselli-Labate AM, Monetti N, et al. Risk indicators of delayed gastric emptying of solids in patients with functional dyspepsia. Gastroenterology 1996;110:1036–1042.

    Article  PubMed  CAS  Google Scholar 

  23. Kohagen KR, Kim MS, McDonnell WM, Chey WD, Owyang C, Hasler WL. Nicotine effects on prostaglandin-dependent gastric slow wave rhythmicity and antral motility in nonsmokers and smokers. Gastroenterology 1996;110:3–11.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan

    Yoshiaki Matsumoto, Masanori Ito, Daisuke Kamino & Kazuaki Chayama

  2. Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan

    Shinji Tanaka

  3. Department of Gastroenterology, Kawasaki Medical School, Kurashiki, Japan

    Ken Haruma

Authors
  1. Yoshiaki Matsumoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Masanori Ito
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Daisuke Kamino
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shinji Tanaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ken Haruma
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kazuaki Chayama
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Matsumoto, Y., Ito, M., Kamino, D. et al. Relation between histologic gastritis and gastric motility in Japanese patients with functional dyspepsia: evaluation by transabdominal ultrasonography. J Gastroenterol 43, 332–337 (2008). https://doi.org/10.1007/s00535-008-2172-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00535-008-2172-y

Key words

Search

Navigation