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Comparative study of the Japan Integrated Stage (JIS) and modified JIS score as a predictor of survival after hepatectomy for hepatocellular carcinoma

  • Liver, Pancreas, and Biliary Tract
  • Published:
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Abstract

Background

The purpose of the study was to compare the abilities of the JIS and modified JIS (m-JIS) scores to predict survival after hepatectomy for hepatocellular carcinoma (HCC).

Methods

Data for patients who underwent hepatectomy for HCC at Hiroshima University Hospital between 1986 and 2006 were included. The overall survival and disease-free survival were calculated by the Kaplan-Meier method, and differences between groups were tested by the log-rank test. The statistics of the Akaike information criterion (AIC) were used to show the more appropriate model.

Results

A total of 626 patients were included (male/female, 468/158; mean age, 63.4 ± 9.6 years; Child-Pugh class A/B, 524/102; liver damage grade A/B/C, 356/261/9). Mean survival and disease-free survival were 8.04±0.39 and 4.69 ± 0.32 years, respectively. There was a significant difference in the overall survival rate between JIS scores 1 and 2, and 2 and 3 (P < 0.05), but not between scores 0 and 1, or 3 and 4 (P > 0.05). Except between m-JIS scores 0 and 1, there was excellent discriminatory ability in overall survival rate between other consecutive groups. Concerning disease-free survival, a significant difference was found only between JIS scores 1 and 2. However, the disease-free survival rate could be well differentiated between m-JIS scores 1 and 2, and 3 and 4. The m-JIS score had a higher discriminatory ability, indicated by a linear trend analysis, and a higher homogeneity likelihood ratio, and lower AIC statistics, than the original JIS score in predicting both overall and disease-free survival.

Conclusions

The modified-JIS scoring system using liver damage grade is better than the original JIS scoring system in predicting survival after hepatectomy for HCC in Japan.

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Authors and Affiliations

  1. Department of Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan

    Kai-Zhong Luo, Toshiyuki Itamoto, Hironobu Amano, Akihiko Oshita, Yuichiro Ushitora, Yoshisato Tanimoto, Hideki Ohdan, Hirotaka Tashiro & Toshimasa Asahara

  2. Institute of Hepatology, The Second Xiangya Hospital, Central South University, Changsha, 410011, China

    Kai-Zhong Luo

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  1. Kai-Zhong Luo
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  2. Toshiyuki Itamoto
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  3. Hironobu Amano
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  4. Akihiko Oshita
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  5. Yuichiro Ushitora
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  6. Yoshisato Tanimoto
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  7. Hideki Ohdan
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  8. Hirotaka Tashiro
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  9. Toshimasa Asahara
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Luo, KZ., Itamoto, T., Amano, H. et al. Comparative study of the Japan Integrated Stage (JIS) and modified JIS score as a predictor of survival after hepatectomy for hepatocellular carcinoma. J Gastroenterol 43, 369–377 (2008). https://doi.org/10.1007/s00535-008-2164-y

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  • DOI: https://doi.org/10.1007/s00535-008-2164-y

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