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Molecular fingerprints of neutrophil-dependent oxidative stress in inflammatory bowel disease

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Abstract

Neutrophil accumulation within epithelial crypts and in the intestinal mucosa directly correlates with clinical disease activity and epithelial injury in inflammatory bowel disease (IBD). Current advances have defined the mechanisms by which neutrophils are activated or migrate across endothelial and mucosal epithelial cells. A better understanding of this process will likely provide new insights into novel treatment strategies for IBD. Especially, activated neutrophils produce reactive oxygen and nitrogen species and myeloperoxidase within intestinal mucosa, which induce oxidative stress. Posttranslational modification of proteins generated by these reactive species serves as a “molecular fingerprint” of protein modification by lipid peroxidation-, nitric oxide-, and myeloperoxidase-derived oxidants. Measurement of these modified proteins may serve both as a quantitative index of oxidative stress and an important new biological marker of clinical relevance to IBD. We have succeeded in the clinical development of a novel granulocyte adsorptive apheresis therapy for IBD. In this review, we discuss current advances in defining the role of neutrophil-dependent oxidative stress in IBD.

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Authors and Affiliations

  1. Medical Proteomics, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan

    Yuji Naito & Toshikazu Yoshikawa

  2. Biosafety Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Tomohisa Takagi & Toshikazu Yoshikawa

  3. Inflammation and Immunology, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Toshikazu Yoshikawa

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  1. Yuji Naito
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  2. Tomohisa Takagi
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  3. Toshikazu Yoshikawa
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Naito, Y., Takagi, T. & Yoshikawa, T. Molecular fingerprints of neutrophil-dependent oxidative stress in inflammatory bowel disease. J Gastroenterol 42, 787–798 (2007). https://doi.org/10.1007/s00535-007-2096-y

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  • DOI: https://doi.org/10.1007/s00535-007-2096-y

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