Skip to main content

Advertisement

Log in

Does oxidative stress participate in the development of hepatocellular carcinoma?

  • Review
  • Published:
Journal of Gastroenterology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. FX Bosch J Ribes M Diaz R Cleries (2004) ArticleTitlePrimary liver cancer: worldwide incidence and trends Gastroenterology 127 S5–16 Occurrence Handle15508102 Occurrence Handle10.1053/j.gastro.2004.09.011

    Article  PubMed  Google Scholar 

  2. XW Wang P Hussain TI Huo CG Wu M Forgues LJ Hofseth et al. (2002) ArticleTitleMolecular pathogenesis of human hepatocellular carcinoma Toxicology 181–2 43–7 Occurrence Handle10.1016/S0300-483X(02)00253-6

    Article  Google Scholar 

  3. S Cowe RW Hardy (2006) ArticleTitleThe metabolic syndrome; a high-risk state for cancer? Am J Pathol 169 1505–22 Occurrence Handle10.2353/ajpath.2006.051090 Occurrence Handle1:CAS:528:DC%2BD28Xht12isr7K

    Article  CAS  Google Scholar 

  4. LM Coussens Z Werb (2002) ArticleTitleInflammation and cancer Nature 420 860–7 Occurrence Handle12490959 Occurrence Handle1:CAS:528:DC%2BD38XpsFygtb4%3D Occurrence Handle10.1038/nature01322

    Article  PubMed  CAS  Google Scholar 

  5. RV Lloyd PM Hanna RP Mason (1997) ArticleTitleThe origin of the hydroxyl radical oxygen in the Fenton reaction Free Radic Biol Med 22 885–8 Occurrence Handle9119257 Occurrence Handle1:CAS:528:DyaK2sXos1ymtg%3D%3D Occurrence Handle10.1016/S0891-5849(96)00432-7

    Article  PubMed  CAS  Google Scholar 

  6. H Inoue H Seitz (2001) ArticleTitleViruses and alcohol in the pathogenesis of primary hepatic primary hepatic carcinoma Eur J Cancer Prev 10 1–4 Occurrence Handle10.1097/00008469-200102000-00016

    Article  Google Scholar 

  7. D Pessayre B Fromentry (2005) ArticleTitleNASH: a mitochondrial disease J Hepatol 42 928–40 Occurrence Handle15885365 Occurrence Handle1:CAS:528:DC%2BD2MXktVGmtL8%3D Occurrence Handle10.1016/j.jhep.2005.03.004

    Article  PubMed  CAS  Google Scholar 

  8. DA Barber SR Harris (1994) ArticleTitleOxygen free radicals and antioxidants: a review Am Pharm 34 26–35

    Google Scholar 

  9. JC Fernandez-Checa N Kaplowitz (2005) ArticleTitleHepatic mitochondrial glutathione: transport and role in disease and toxicity Toxicol Appl Pharmacol 204 263–73 Occurrence Handle15845418 Occurrence Handle1:CAS:528:DC%2BD2MXjsFGqt78%3D Occurrence Handle10.1016/j.taap.2004.10.001

    Article  PubMed  CAS  Google Scholar 

  10. DJ Betteridge (2000) ArticleTitleWhat is oxidative stress? Metabolisms 49 3–8 Occurrence Handle1:CAS:528:DC%2BD3cXht1yhsbs%3D

    CAS  Google Scholar 

  11. DV Parke (1994) ArticleTitleThe cytochrome p450 and mechanisms of chemical carcinogenesis Environ Health Perspect 102 852–3 Occurrence Handle9644192 Occurrence Handle1:STN:280:DyaK1cvgvF2nsQ%3D%3D

    PubMed  CAS  Google Scholar 

  12. LD Gorsky DR Koop MJ Conn (1984) ArticleTitleOn the stoichiometry of the oxidase and monooxygenase reactions catalyzed by liver microsomal cytochrome p450 J Biol Chem 259 6812–7 Occurrence Handle6725272 Occurrence Handle1:CAS:528:DyaL2cXksFSks7w%3D

    PubMed  CAS  Google Scholar 

  13. DR Koop (1992) ArticleTitleOxidative and reductive metabolism by cytochrome p4502E1 FASEB J 6 724–30 Occurrence Handle1537462 Occurrence Handle1:CAS:528:DyaK38XhtVSltL8%3D

    PubMed  CAS  Google Scholar 

  14. MS Rao JK Reddy (1991) ArticleTitleAn overview of peroxisome proliferators-induced hepatocarcinogenesis Environ Health Perspect 93 205–9 Occurrence Handle1685443 Occurrence Handle1:STN:280:DyaK387ivVClsw%3D%3D

    PubMed  CAS  Google Scholar 

  15. Roberts RA, Ganey PE, Kamendulis LM, Rusyn I, Klaunig JE. Role of the Kupffer cell mediating hepatic toxicity and carcinogenesis. Toxicol Sci 2006 Nov 22; [Epub ahead of print]

  16. AM Seisky LM Kamendulis JE Klaunig (2002) ArticleTitleHepatic effects of 2-butoxyethanol in rodents Toxicol Sci 70 252–60 Occurrence Handle10.1093/toxsci/70.2.252

    Article  Google Scholar 

  17. JC Fernandez-Checa (2003) ArticleTitleRedox regulation and signaling lipids in mitochondrial apoptosis Biochem Biophys Res Commun 304 471–9 Occurrence Handle12729581 Occurrence Handle1:CAS:528:DC%2BD3sXjt1Kisrg%3D Occurrence Handle10.1016/S0006-291X(03)00619-3

    Article  PubMed  CAS  Google Scholar 

  18. FQ Schafer GR Buettner (2001) ArticleTitleRedox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple Free Radic Biol Med 30 1191–212 Occurrence Handle11368918 Occurrence Handle1:CAS:528:DC%2BD3MXjsFegt78%3D Occurrence Handle10.1016/S0891-5849(01)00480-4

    Article  PubMed  CAS  Google Scholar 

  19. T Finkel (2000) ArticleTitleRedox-dependent signal transduction FEBS Lett 476 52–4 Occurrence Handle10878249 Occurrence Handle1:CAS:528:DC%2BD3cXktlKqsbo%3D Occurrence Handle10.1016/S0014-5793(00)01669-0

    Article  PubMed  CAS  Google Scholar 

  20. A Holmgren (1985) ArticleTitleThioredoxin Annu Rev Biochem 54 237–41 Occurrence Handle3896121 Occurrence Handle1:STN:280:DyaL2M3nsl2rug%3D%3D Occurrence Handle10.1146/annurev.bi.54.070185.001321

    Article  PubMed  CAS  Google Scholar 

  21. H Nakamura K Nakamura J Yodoi (1997) ArticleTitleRedox regulation of cellular activation Annu Rev Immunol 15 351–69 Occurrence Handle9143692 Occurrence Handle1:CAS:528:DyaK2sXisVCmsbw%3D Occurrence Handle10.1146/annurev.immunol.15.1.351

    Article  PubMed  CAS  Google Scholar 

  22. H Nakamura (2004) ArticleTitleThioredoxin as a key molecule in redox signaling Antioxid Redox Signal 6 15–7 Occurrence Handle14713332 Occurrence Handle1:CAS:528:DC%2BD2cXhs1ensg%3D%3D Occurrence Handle10.1089/152308604771978309

    Article  PubMed  CAS  Google Scholar 

  23. JS Beckman WH Koppenol (1996) ArticleTitleNitric oxide, superoxide, and peroxynitrite: the good, the bad, and the ugly Am J Physiol Cell Physiol 271 C1424–37 Occurrence Handle1:CAS:528:DyaK28XntFymtrc%3D

    CAS  Google Scholar 

  24. CG Fraga MK Shigenaga JW Park P Degan BN Ames (1990) ArticleTitleOxidative damage to DNA during aging: 8-hydroxy-2′-deoxyguanosine in rat organ DNA and urine Proc Natl Acad Sci USA 87 4533–7 Occurrence Handle2352934 Occurrence Handle1:CAS:528:DyaK3cXkslGqsrk%3D Occurrence Handle10.1073/pnas.87.12.4533

    Article  PubMed  CAS  Google Scholar 

  25. KC Cheng H Cahill S Kasai S Nishimura LA Loeb (1992) ArticleTitle8-Hydroxyguanine, an abundant from oxidative DNA damage, causes G → T and A → C substitutions J Biol Chem 267 166–72 Occurrence Handle1730583 Occurrence Handle1:CAS:528:DyaK38XjvFWlug%3D%3D

    PubMed  CAS  Google Scholar 

  26. S Loft HE Poulsen (1996) ArticleTitleCancer risk and oxidative DNA damage in man J Mol Med 74 297–312 Occurrence Handle8862511 Occurrence Handle1:CAS:528:DyaK28XjvFWnsLY%3D Occurrence Handle10.1007/s001090050031

    Article  PubMed  CAS  Google Scholar 

  27. SP Hussain CC Haris (1998) ArticleTitleMolecular epidemiology of human cancer: contribution of mutation spectra studies of tumor suppressor genes Cancer Res 58 4023–37 Occurrence Handle9751603 Occurrence Handle1:CAS:528:DyaK1cXmtlClu7g%3D

    PubMed  CAS  Google Scholar 

  28. H Zhang LM Kamendulis Y Xu JE Klaunig (2000) ArticleTitleThe role of 8-hydroxy-2′-deoxyguanosine in morphological transformation of Syrian hamster embryo (SHE) cells Toxicol Sci 56 303–12 Occurrence Handle10910988 Occurrence Handle1:CAS:528:DC%2BD3cXlsVCjtb4%3D Occurrence Handle10.1093/toxsci/56.2.303

    Article  PubMed  CAS  Google Scholar 

  29. T Bessho R Roy K Yamamoto H Kasai S Nishimura K Tano et al. (1993) ArticleTitleRepair of 8-hydroxy guanine in DNA by mammalian N-methylpurine-DNA glycosylase Proc Natl Acad Sci USA 90 8901–4 Occurrence Handle8415629 Occurrence Handle1:CAS:528:DyaK2cXjs1Ci Occurrence Handle10.1073/pnas.90.19.8901

    Article  PubMed  CAS  Google Scholar 

  30. S Baylin JG Herman JR Graff PM Vertino JP Issa (1998) ArticleTitleAlterations in DNA methylation: a fundamental aspect of neoplasia Adv Cancer Res 72 141–96 Occurrence Handle9338076 Occurrence Handle1:CAS:528:DyaK2sXotVyktr8%3D Occurrence Handle10.1016/S0065-230X(08)60702-2

    Article  PubMed  CAS  Google Scholar 

  31. JL Counts JI Goodman (1995) ArticleTitleAlterations in DNA methylation may play a variety of roles in carcinogenesis Cell 83 13–5 Occurrence Handle7553865 Occurrence Handle1:CAS:528:DyaK2MXosF2kurY%3D Occurrence Handle10.1016/0092-8674(95)90228-7

    Article  PubMed  CAS  Google Scholar 

  32. M Toyota N Ahuja M Ohe-Toyota JG Herman SB Baylin JP Issa (1999) ArticleTitleCpG island methylator phenotype in colorectal cancer Proc Natl Acad Sci USA 96 8681–6 Occurrence Handle10411935 Occurrence Handle1:CAS:528:DyaK1MXkslOktLg%3D Occurrence Handle10.1073/pnas.96.15.8681

    Article  PubMed  CAS  Google Scholar 

  33. PA Jones PW Laird (1999) ArticleTitleCancer epigenetics comes of age Nat Genet 21 163–7 Occurrence Handle9988266 Occurrence Handle1:CAS:528:DyaK1MXpsVClug%3D%3D Occurrence Handle10.1038/5947

    Article  PubMed  CAS  Google Scholar 

  34. SA Weitzman PW Turk DH Milkowski K Kozlowski (1994) ArticleTitleFree radical adducts induce alterations in DNA cytosine methylation Proc Natl Acad Sci USA 91 1261–4 Occurrence Handle8108398 Occurrence Handle1:CAS:528:DyaK2cXitlOqtL8%3D Occurrence Handle10.1073/pnas.91.4.1261

    Article  PubMed  CAS  Google Scholar 

  35. H Kaneto S Sasaki H Yamamoto F Itoh M Toyota H Suzuki et al. (2001) ArticleTitleDetection of hypermethylation of the p16INK4 gene promoter in chronic hepatitis and cirrhosis associated with hepatitis B or C virus Gut 48 372–7 Occurrence Handle11171828 Occurrence Handle1:CAS:528:DC%2BD3MXitlCjur0%3D Occurrence Handle10.1136/gut.48.3.372

    Article  PubMed  CAS  Google Scholar 

  36. H Miyoshi H Fujie K Moriya Y Shintani T Tsutsumi M Makuuchi et al. (2004) ArticleTitleMethylation status of suppressor of cytokine signaling-1 gene in hepatocellular carcinoma J Gastroenterol 39 563–9 Occurrence Handle15235874 Occurrence Handle1:CAS:528:DC%2BD2cXlt1ylsLY%3D Occurrence Handle10.1007/s00535-003-1343-0

    Article  PubMed  CAS  Google Scholar 

  37. B Govindarajan R Klafter MS Miller C Mansur M Mizesko X Bai et al. (2002) ArticleTitleReactive oxygen-induced carcinogenesis causes hypermethylation of p16(INK4a) and activation of MAP kinase Mol Med 8 1–8 Occurrence Handle11984000 Occurrence Handle1:CAS:528:DC%2BD38XjsVCktbg%3D Occurrence Handle10.1007/s00894-001-0054-9

    Article  PubMed  CAS  Google Scholar 

  38. L Sun AM Hui Y Kanai M Sakamoto S Hirohashi (1997) ArticleTitleIncreased DNA methyltransferase expression is associated with an early stage of human hepatocarcinogenesis Jpn J Cancer Res 88 1165–70 Occurrence Handle9473734 Occurrence Handle1:CAS:528:DyaK1cXhtlamsQ%3D%3D

    PubMed  CAS  Google Scholar 

  39. THM Huang MR Perry DE Laux (1999) ArticleTitleMethylation profiling of CpG islands in human breast cancer cells Hum Mol Genet 8 459–70 Occurrence Handle9949205 Occurrence Handle1:CAS:528:DyaK1MXhslKlsrc%3D Occurrence Handle10.1093/hmg/8.3.459

    Article  PubMed  CAS  Google Scholar 

  40. J Zhu (2005) ArticleTitleDNA methylation pattern and its implications in liver cancer Cell Res 15 272–80 Occurrence Handle15857582 Occurrence Handle1:CAS:528:DC%2BD2MXhtFWntrzP Occurrence Handle10.1038/sj.cr.7290296

    Article  PubMed  CAS  Google Scholar 

  41. JW Shay H Werbin (1992) ArticleTitleNew evidence for the insertion of mitochondrial DNA into the human genome: significance for cancer and aging Mutat Res 275 227–35 Occurrence Handle1383764 Occurrence Handle1:CAS:528:DyaK3sXkvVGq

    PubMed  CAS  Google Scholar 

  42. H Bartsch J Nair (2004) ArticleTitleOxidative stress and lipid peroxidation-derived DNA-lesions in inflammation driven carcinogenesis Cancer Detect Prev 28 385–91 Occurrence Handle15582261 Occurrence Handle1:CAS:528:DC%2BD2MXhtVCgsbo%3D Occurrence Handle10.1016/j.cdp.2004.07.004

    Article  PubMed  CAS  Google Scholar 

  43. JM Dypbukt M Ankarcrona M Burkitt A Sjoholm K Strome S Orrenius et al. (1994) ArticleTitleDifferent prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells. The role of intracellular polyamines J Biol Chem 269 30553–60 Occurrence Handle7982974 Occurrence Handle1:CAS:528:DyaK2cXmslOqur0%3D

    PubMed  CAS  Google Scholar 

  44. JL Martindale NJ Holbrook (2002) ArticleTitleCellular response to oxidative stress: signaling for suicide and survival J Cell Physiol 192 1–15 Occurrence Handle12115731 Occurrence Handle1:CAS:528:DC%2BD38XksVGmurc%3D Occurrence Handle10.1002/jcp.10119

    Article  PubMed  CAS  Google Scholar 

  45. QM Chen JL Martindale NJ Holbrook J Liu (1998) ArticleTitleTumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and Shc Mol Cell Biol 18 5178–88 Occurrence Handle9710602 Occurrence Handle1:CAS:528:DyaK1cXls1Sgt7Y%3D

    PubMed  CAS  Google Scholar 

  46. A Knebel HJ Rahmsdorf A Ullrich P Herrlich (1996) ArticleTitleDephosphorylation of receptor tyrosine kinases as target of regulation by radiation oxidants or alkylating agents EMBO J 15 5314–25 Occurrence Handle8895576 Occurrence Handle1:CAS:528:DyaK28XmsVeiu7s%3D

    PubMed  CAS  Google Scholar 

  47. M Saitoh H Nishitoh M Fujii K Takeda K Tobiume Y Sawada et al. (1998) ArticleTitleMammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase(ASK)1 EMBO J 17 2596–606 Occurrence Handle9564042 Occurrence Handle1:CAS:528:DyaK1cXjsVWgs78%3D Occurrence Handle10.1093/emboj/17.9.2596

    Article  PubMed  CAS  Google Scholar 

  48. V Alder Z Yin SY Fuchs M Benezra L Rosario KD Tew et al. (1999) ArticleTitleRegulation of JNK signaling by GSTp EMBO J 18 1321–34 Occurrence Handle10.1093/emboj/18.5.1321

    Article  Google Scholar 

  49. K Iyoda Y Sasaki M Horimoto T Toyama T Yakushijin M Sakakibara et al. (2003) ArticleTitleInvolvement of the p38 mitogen-activated protein kinase cascade in hepatocellular carcinoma Cancer 97 3017–26 Occurrence Handle12784337 Occurrence Handle1:CAS:528:DC%2BD3sXlt1Shurw%3D Occurrence Handle10.1002/cncr.11425

    Article  PubMed  CAS  Google Scholar 

  50. S Nemoto J Xiang S Huang A Lin (1998) ArticleTitleInduction of apoptosis by SB202190 through inhibition of p38betamitogen-activated protein kinase J Biol Chem 273 16415–20 Occurrence Handle9632706 Occurrence Handle1:CAS:528:DyaK1cXkt1Gis7Y%3D Occurrence Handle10.1074/jbc.273.26.16415

    Article  PubMed  CAS  Google Scholar 

  51. JM Muller MA Cahill RA Rupee PA Baeuerle A Nordheim (1997) ArticleTitleAntioxidants as well as oxidants activate c-fos via RAS–dependent activation of extracellular signal-regulated kinase 2 and Elk-1 Eur J Biochem 244 45–52 Occurrence Handle9063444 Occurrence Handle1:STN:280:DyaK2s3hslChsQ%3D%3D Occurrence Handle10.1111/j.1432-1033.1997.00045.x

    Article  PubMed  CAS  Google Scholar 

  52. Y Chinenov TK Kerppola (2001) ArticleTitleClose encounters of many kinds: Fos–Jun interactions that mediate transcriptional regulatory specificity Oncogene 20 2438–52 Occurrence Handle11402339 Occurrence Handle1:STN:280:DC%2BD3Mzjt1Oisg%3D%3D Occurrence Handle10.1038/sj.onc.1204385

    Article  PubMed  CAS  Google Scholar 

  53. JR Brown E Nigh RJ Lee H Ye MA Thompson F Saudou et al. (1998) ArticleTitleFos family members induce cell cycle entry by activating cyclin D1 Mol Cell Biol 18 5609–19 Occurrence Handle9710644 Occurrence Handle1:CAS:528:DyaK1cXls1Snsrw%3D

    PubMed  CAS  Google Scholar 

  54. J Schutte JD Minna MI Birer (1989) ArticleTitleDeregulated expression of human c-jun transforms primary rat embryo cells in cooperation with an activated c-Ha-ras gene and transforms rat-1a cells as a single gene Proc Natl Acad Sci USA 86 2257–61 Occurrence Handle2648396 Occurrence Handle1:STN:280:DyaL1M7osVKjtQ%3D%3D Occurrence Handle10.1073/pnas.86.7.2257

    Article  PubMed  CAS  Google Scholar 

  55. F Chen V Castranova X Shi (2001) ArticleTitleNew insights into the role of nuclear factor-κB in cell growth regulation Am J Pathol 159 387–97 Occurrence Handle11485895 Occurrence Handle1:CAS:528:DC%2BD3MXms1WisLs%3D

    PubMed  CAS  Google Scholar 

  56. S Schoonbroodt J Piette (2000) ArticleTitleOxidative stress interference with the nuclear factor-κB activation pathways Biochem Pharmacol 60 1075–83 Occurrence Handle11007944 Occurrence Handle1:CAS:528:DC%2BD3cXmslOjsb4%3D Occurrence Handle10.1016/S0006-2952(00)00371-3

    Article  PubMed  CAS  Google Scholar 

  57. L Flohe B Brigelius-Flohe C Saliou MG Traber L Packer (1997) ArticleTitleRedox regulation of NF-κB activation Free Radic Biol Med 22 1115–26 Occurrence Handle9034250 Occurrence Handle1:CAS:528:DyaK2sXht1altb8%3D Occurrence Handle10.1016/S0891-5849(96)00501-1

    Article  PubMed  CAS  Google Scholar 

  58. AS Baldwin SuffixJr (1996) ArticleTitleThe NFκB and IκB proteins: new discoveries and insights Annu Rev Immunol 14 649–83 Occurrence Handle8717528 Occurrence Handle1:CAS:528:DyaK28XitlCgtbc%3D Occurrence Handle10.1146/annurev.immunol.14.1.649

    Article  PubMed  CAS  Google Scholar 

  59. HL Pahl (1999) ArticleTitleActivators and target genes of Rel/NF-κB transcriptional factors Oncogene 18 6853–66 Occurrence Handle10602461 Occurrence Handle1:CAS:528:DyaK1MXotVyhtL0%3D Occurrence Handle10.1038/sj.onc.1203239

    Article  PubMed  CAS  Google Scholar 

  60. WR Taylor GR Stark (2001) ArticleTitleRegulation of the G2/M transition by p53 Oncogene 20 1803–15 Occurrence Handle11313928 Occurrence Handle1:CAS:528:DC%2BD3MXivFKhtr4%3D Occurrence Handle10.1038/sj.onc.1204252

    Article  PubMed  CAS  Google Scholar 

  61. N Kondoh T Wakatsuki A Hada M Shuda K Tanaka M Arai et al. (2001) ArticleTitleGenetic and epigenetic events in human hepatocarcinogenesis Int J Oncol 18 1271–8 Occurrence Handle11351262 Occurrence Handle1:CAS:528:DC%2BD3MXktlCjsLg%3D

    PubMed  CAS  Google Scholar 

  62. SF Ding NA Habib (1995) ArticleTitleLoss of heterozygosity in liver tumours J Hepatol 22 230–8 Occurrence Handle7790712 Occurrence Handle1:STN:280:DyaK2MzhtVOhtg%3D%3D Occurrence Handle10.1016/0168-8278(95)80434-X

    Article  PubMed  CAS  Google Scholar 

  63. Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B. A model for p53-induced apoptosis. Nature 1997;300–5

  64. AJ Levine (1997) ArticleTitlep53, the cellular gatekeeper for growth and division Cell 88 323–31 Occurrence Handle9039259 Occurrence Handle1:CAS:528:DyaK2sXhtFahtLg%3D Occurrence Handle10.1016/S0092-8674(00)81871-1

    Article  PubMed  CAS  Google Scholar 

  65. Y Sumida T Nakashima T Yoh Y Nakajima H Ishikawa H Mitsuyoshi et al. (2000) ArticleTitleSerum thioredoxin levels as an indicator of oxidative stress in patients with hepatitis C virus infection J Hepatol 13 159–63

    Google Scholar 

  66. S Mahmood M Kawanaka A Kamei A Izumi K Nakata G Niiyama et al. (2004) ArticleTitleImmunohistochemical evaluation of oxidative stress markers in chronic hepatitis C Antioxid Redox Signal 6 19–24 Occurrence Handle14713333 Occurrence Handle1:CAS:528:DC%2BD2cXhs1ensw%3D%3D Occurrence Handle10.1089/152308604771978318

    Article  PubMed  CAS  Google Scholar 

  67. R Takeya H Sumimoto (2006) ArticleTitleRegulation of novel superoxide-producing NAD(P)H oxidases Antioxid Redox Signal 8 1523–32 Occurrence Handle16987008 Occurrence Handle1:CAS:528:DC%2BD28XpslalsbY%3D Occurrence Handle10.1089/ars.2006.8.1523

    Article  PubMed  CAS  Google Scholar 

  68. F Thoren A Romero M Lindh C Dahlgren K Hellstrand (2004) ArticleTitleA hepatitis C virus-encoded, non-structural protein (NS3) triggers dysfunction and apoptosis in lymphocytes: role of NADPH oxidase-derived oxygen radicals J Leukoc Biol 76 1180–6 Occurrence Handle15371490 Occurrence Handle1:CAS:528:DC%2BD2cXhtFSit7jE Occurrence Handle10.1189/jlb.0704387

    Article  PubMed  CAS  Google Scholar 

  69. K Moriya K Nakagawa T Santa Y Shintani H Fujie H Miyoshi et al. (2001) ArticleTitleOxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis Cancer Res 61 4365–70 Occurrence Handle11389061 Occurrence Handle1:CAS:528:DC%2BD3MXktlSqu7o%3D

    PubMed  CAS  Google Scholar 

  70. M Korenaga TL Wang LA Showalter T Chan J Sun SA Weinman (2005) ArticleTitleHepatitis C virus core protein inhibits mitochondrial electron transport and increase ROS production J Biol Chem 280 37481–8 Occurrence Handle16150732 Occurrence Handle1:CAS:528:DC%2BD2MXhtF2isrvE Occurrence Handle10.1074/jbc.M506412200

    Article  PubMed  CAS  Google Scholar 

  71. K Koike K Moriya (2005) ArticleTitleMetabolic aspects of hepatitis C viral infection: steatohepatitis resembling but distinct from NASH J Gastroenterol 40 329–36 Occurrence Handle15868369 Occurrence Handle1:CAS:528:DC%2BD2MXjvVansrg%3D Occurrence Handle10.1007/s00535-005-1586-z

    Article  PubMed  CAS  Google Scholar 

  72. N Pavio PR Romano TM Graczyk SM Feinstone DR Taylor (2003) ArticleTitleProtein synthesis and endoplasmic reticulum stress can be modulated by the hepatitis C virus envelope protein E2 through the eukaryotic initiation factor 2 alpha kinase PERK J Virol 77 3578–85 Occurrence Handle12610133 Occurrence Handle1:CAS:528:DC%2BD3sXhvF2jsr8%3D Occurrence Handle10.1128/JVI.77.6.3578-3585.2003

    Article  PubMed  CAS  Google Scholar 

  73. KD Tardif G Waris A Siddiqui (2005) ArticleTitleHepatitis C virus, ER stress, and oxidative stress Trends Microbiol 13 159–63 Occurrence Handle15817385 Occurrence Handle1:CAS:528:DC%2BD2MXjtVyqs7c%3D Occurrence Handle10.1016/j.tim.2005.02.004

    Article  PubMed  CAS  Google Scholar 

  74. Y Ma LM Hendershot (2002) ArticleTitleThe mammalian endoplasmic reticulum as a sensor for cellular stress Cell Stress Chaperones 7 222–9 Occurrence Handle12380691 Occurrence Handle1:CAS:528:DC%2BD38XptV2gsb4%3D Occurrence Handle10.1379/1466-1268(2002)007<0222:TMERAA>2.0.CO;2

    Article  PubMed  CAS  Google Scholar 

  75. MY Abdalla IM Ahmad DR Spitz WN Schmidt BE Britigan (2005) ArticleTitleHepatitis C virus-core and nonstructural proteins lead to different effects on cellular antioxidant defenses J Med Virol 76 489–97 Occurrence Handle15977232 Occurrence Handle1:CAS:528:DC%2BD2MXmvVymurg%3D Occurrence Handle10.1002/jmv.20388

    Article  PubMed  CAS  Google Scholar 

  76. K Moriya H Fujie Y Shintani H Yotsuyanagi T Tsutsumi K Ishibashi et al. (1998) ArticleTitleThe core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice Nat Med 4 1065–7 Occurrence Handle9734402 Occurrence Handle1:CAS:528:DyaK1cXlvFGns7o%3D Occurrence Handle10.1038/2053

    Article  PubMed  CAS  Google Scholar 

  77. G Guozhong G Waris R Tanveer A Siddiqui (2001) ArticleTitleHuman hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NFκB Proc Natl Acad Sci USA 98 9599–604 Occurrence Handle10.1073/pnas.171311298

    Article  Google Scholar 

  78. K Machida KT Cheng VM Sung KJ Lee AM Levine MM Lai (2004) ArticleTitleHepatitis C virus infection activates the immunologic (type II) isoform of nitric oxide synthase and thereby enhances DNA damage and mutations of cellular genes J Virol 78 8835–43 Occurrence Handle15280491 Occurrence Handle1:CAS:528:DC%2BD2cXmslWqs7Y%3D Occurrence Handle10.1128/JVI.78.16.8835-8843.2004

    Article  PubMed  CAS  Google Scholar 

  79. G Waris A Siddiqui (2005) ArticleTitleHepatitis C virus stimulates the expression of cyclooxygenase-2 via oxidative stress: role of prostaglandin E2 in RNA replication J Virol 79 9725–34 Occurrence Handle16014934 Occurrence Handle1:CAS:528:DC%2BD2MXmvVels70%3D Occurrence Handle10.1128/JVI.79.15.9725-9734.2005

    Article  PubMed  CAS  Google Scholar 

  80. M Tsujii S Kawano RN Dubois (1997) ArticleTitleCycooxygenase-2 expression in human colon cancer cells increases metastatic potential Proc Natl Acad Sci USA 94 3336–40 Occurrence Handle9096394 Occurrence Handle1:CAS:528:DyaK2sXisVKnsr8%3D Occurrence Handle10.1073/pnas.94.7.3336

    Article  PubMed  CAS  Google Scholar 

  81. Y Ito Y Sasaki T Ito S Wada Y Tanaka A Kasahara et al. (1998) ArticleTitleActivation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinoma Hepatology 27 951–8 Occurrence Handle9537433 Occurrence Handle1:CAS:528:DyaK1cXisFCksbg%3D Occurrence Handle10.1002/hep.510270409

    Article  PubMed  CAS  Google Scholar 

  82. MB Reddy L Clard (2004) ArticleTitleIron oxidative stress and disease risk Nutr Rev 62 120–4 Occurrence Handle15098859 Occurrence Handle10.1301/nr.2004.mar.120-124

    Article  PubMed  Google Scholar 

  83. T Furutani K Hino M Okuda T Gondo S Nishina A Kitase et al. (2006) ArticleTitleHepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein Gastroenterology 130 2087–98 Occurrence Handle16762631 Occurrence Handle1:CAS:528:DC%2BD28XntVWit78%3D Occurrence Handle10.1053/j.gastro.2006.02.060

    Article  PubMed  CAS  Google Scholar 

  84. M Yano H Hayashi K Yoshiola Y Kohgo H Saito Y Niitsu et al. (2004) ArticleTitleA significant reduction in serum alanine aminotransferase levels after 3-month iron reduction therapy for chronic hepatitis C: a multicenter, prospective, randomized, controlled trail in Japan J Gastroenterol 39 570–4 Occurrence Handle15235875 Occurrence Handle1:CAS:528:DC%2BD2cXlt1ylsLk%3D Occurrence Handle10.1007/s00535-003-1344-z

    Article  PubMed  CAS  Google Scholar 

  85. TM Hagen S Huang J Curnutte P Fowler V Martinez CM Weher et al. (1994) ArticleTitleExtensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma Proc Natl Acad Sci USA 91 12808–12 Occurrence Handle7809125 Occurrence Handle1:CAS:528:DyaK2MXivVCqsr4%3D Occurrence Handle10.1073/pnas.91.26.12808

    Article  PubMed  CAS  Google Scholar 

  86. Y Nakamoto T Suda T Momoi S Kaneko (2004) ArticleTitleDifferent procarcinogenic potentials of lymphocyte subsets in a transgenic mouse model of chronic hepatitis B Cancer Res 64 3326–33 Occurrence Handle15126377 Occurrence Handle1:CAS:528:DC%2BD2cXjs1ehtbs%3D Occurrence Handle10.1158/0008-5472.CAN-03-3817

    Article  PubMed  CAS  Google Scholar 

  87. CR Madden MJ Finegold BL Slagle (2001) ArticleTitleHepatitis B virus X protein acts as a tumor promoter in development of diethylnitrosamine-induced preneoplastic lesions J Virol 75 3851–8 Occurrence Handle11264374 Occurrence Handle1:CAS:528:DC%2BD3MXisVSms7c%3D Occurrence Handle10.1128/JVI.75.8.3851-3858.2001

    Article  PubMed  CAS  Google Scholar 

  88. O Terradillos O Billet CA Renard R Levy T Molina P Briand et al. (1997) ArticleTitleThe hepatitis B x gene potentiates c-myc-induced liver oncogenesis in transgenic mice Oncogene 14 395–404 Occurrence Handle9053836 Occurrence Handle1:CAS:528:DyaK2sXht1ensb4%3D Occurrence Handle10.1038/sj.onc.1200850

    Article  PubMed  CAS  Google Scholar 

  89. G Waris KW Huh A Siddiqui (2001) ArticleTitleMitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT3 and NFκB via oxidative stress Mol Cell Biol 21 7721–30 Occurrence Handle11604508 Occurrence Handle1:CAS:528:DC%2BD3MXnvVWltro%3D Occurrence Handle10.1128/MCB.21.22.7721-7730.2001

    Article  PubMed  CAS  Google Scholar 

  90. F Stickel D Schuppan EG Hahn HK Seitz (2002) ArticleTitleCocarcinogenic effects of alcohol in hepatocarcinogenesis Gut 51 132–9 Occurrence Handle12077107 Occurrence Handle1:CAS:528:DC%2BD38XlslOis7o%3D Occurrence Handle10.1136/gut.51.1.132

    Article  PubMed  CAS  Google Scholar 

  91. JL Fang CE Vaca (1995) ArticleTitleDevelopment of a 32P-postlabeling method for the analysis of adducts arising through the reaction of acetaldehyde with 2′-deoxyguanosine-3′-monophosophate and DNA Carcinogenesis 16 2177–85 Occurrence Handle7554072 Occurrence Handle1:CAS:528:DyaK2MXot1ans7c%3D Occurrence Handle10.1093/carcin/16.9.2177

    Article  PubMed  CAS  Google Scholar 

  92. N Espina V Lima CS Lieber AJ Garro (1988) ArticleTitleIn vitro and in vivo inhibitory effect of ethanol and acetaldehyde on O6-methyguanine transferase Carcinogenesis 9 761–6 Occurrence Handle3365837 Occurrence Handle1:CAS:528:DyaL1cXktFylsr0%3D Occurrence Handle10.1093/carcin/9.5.761

    Article  PubMed  CAS  Google Scholar 

  93. JB Minana L Gomez-Cambronero A Lloret FV Pallardo J Del Olmo A Escudero et al. (2002) ArticleTitleMitochondrial oxidative stress and CD95 ligand: a dual mechanisms for hepatocyte apoptosis in chronic alcoholisms Hepatology 35 1205–14 Occurrence Handle11981771 Occurrence Handle1:CAS:528:DC%2BD38XktF2hu7s%3D Occurrence Handle10.1053/jhep.2002.32969

    Article  PubMed  CAS  Google Scholar 

  94. G Novitskiy K Traore L Wang MA Trush E Mezey (2006) ArticleTitleEffects of ethanol and acetaldehyde on reactive oxygen species production in rat hepatic stellate cells Alcohol Clin Exp Res 30 1429–35 Occurrence Handle16899047 Occurrence Handle1:CAS:528:DC%2BD28XovFyltLg%3D Occurrence Handle10.1111/j.1530-0277.2006.00171.x

    Article  PubMed  CAS  Google Scholar 

  95. E Borras C Coutelle A Rosell F Fernandez-Muixi M Broch B Crosas et al. (2000) ArticleTitleGenetic polymorphism of alcohol dehydrogenase in Europeans: the ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1 Hepatology 31 984–9 Occurrence Handle10733556 Occurrence Handle1:CAS:528:DC%2BD3cXis1Cks7k%3D Occurrence Handle10.1053/he.2000.5978

    Article  PubMed  CAS  Google Scholar 

  96. HK Seitz S Matsuzaki A Yokoyama N Homann S Vakevainen XD Wang (2001) ArticleTitleAlcohol and cancer Alcoholism Clinical Exp Res 25 137–43

    Google Scholar 

  97. J Nair H Sone M Nagao A Barbin H Bartsch (1996) ArticleTitleCopper-dependent formation of miscoding ethano-DNA adducts in the liver of Long Evans cinnamon (LEC) rats developing hereditary hepatitis and hepatocellular carcinoma Cancer Res 56 1267–71 Occurrence Handle8640812 Occurrence Handle1:CAS:528:DyaK28XhsFGnsbc%3D

    PubMed  CAS  Google Scholar 

  98. HBR Seitz (1992) Effect of ethanol on procarcinogen activation R Watson (Eds) Alcohol and cancer CRC Press Boca Raton, FL 55–72

    Google Scholar 

  99. JM Ladero JA Agundez A Rodriguez-Lescure M Diaz-Rubio JR Benitez (1996) ArticleTitleRsal polymorphism at the cytochrome p4502E1 locus and risk of hepatocellular carcinoma Gut 39 330–3 Occurrence Handle8977352 Occurrence Handle1:CAS:528:DyaK28Xmt1eitLs%3D

    PubMed  CAS  Google Scholar 

  100. KT Knecht BU Bradford RP Mason RG Thurman (1990) ArticleTitleIn vivo formation of a free radical metabolite of ethanol Mol Pharmacol 38 26–30 Occurrence Handle2370854 Occurrence Handle1:CAS:528:DyaK3cXlsVOisr8%3D

    PubMed  CAS  Google Scholar 

  101. H Tsukamoto M Lin M Ohata C Giulvi SW French G Brittenham (1999) ArticleTitleIron primes hepatic macrophages for NFκB activation in alcoholic liver injury Am J Physiol Gastrointest Liver Physiol 277 G1240–50 Occurrence Handle1:CAS:528:DC%2BD3cXhs1ygsg%3D%3D

    CAS  Google Scholar 

  102. CJ McClain S Barve I Deaciuc M Kugelmas D Hill (1999) ArticleTitleCytokines in alcoholic liver disease Semin Liver Dis 19 205–19 Occurrence Handle10422201 Occurrence Handle1:CAS:528:DyaK1MXkvFeis74%3D Occurrence Handle10.1055/s-2007-1007110

    Article  PubMed  CAS  Google Scholar 

  103. Z Zhou L Wang Z Song JC Lambert CJ McClain YJ Kang (2003) ArticleTitleA critical involvement of oxidative stress in acute alcohol-induced hepatic TNFα production Am J Pathol 163 1137–46 Occurrence Handle12937155 Occurrence Handle1:CAS:528:DC%2BD3sXnsVCis78%3D

    PubMed  CAS  Google Scholar 

  104. SA Weitzman PW Turk DH Milkowski K Kozlowski (1994) ArticleTitleFree radical adducts induce alterations in DNA cytosine methylation Proc Natl Acad Sci USA 91 1261–4 Occurrence Handle8108398 Occurrence Handle1:CAS:528:DyaK2cXitlOqtL8%3D Occurrence Handle10.1073/pnas.91.4.1261

    Article  PubMed  CAS  Google Scholar 

  105. F Stickel SW Choi YI Kim PJ Bagley HK Seitz RM Russell et al. (2000) ArticleTitleEffect of chronic alcohol consumption on total plasma homocysteine level in rats Alcohol Clin Exp Res 24 259–64 Occurrence Handle10776661 Occurrence Handle1:CAS:528:DC%2BD3cXivVShsL0%3D Occurrence Handle10.1111/j.1530-0277.2000.tb04606.x

    Article  PubMed  CAS  Google Scholar 

  106. IP Pogribny AG Basnakian BJ Miller NG Lopatina LA Poirier SJ James (1995) ArticleTitleBreaks in genomic DNA and within p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats Cancer Res 5 1894–901

    Google Scholar 

  107. AE Feldstein A Canbay P Angulo M Taniai LJ Burgart KD Lindor et al. (2003) ArticleTitleHepatocyte apoptosis and Fas expression are prominent features of human nonalcoholic steatohepatitis Gastroenterology 125 437–43 Occurrence Handle12891546 Occurrence Handle10.1016/S0016-5085(03)00907-7

    Article  PubMed  Google Scholar 

  108. JM Hui JG Kench S Chitturi A Suda GC Farrell K Byth et al. (2003) ArticleTitleLong-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C Hepatology 38 420–7 Occurrence Handle12883486 Occurrence Handle10.1053/jhep.2003.50320

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sasaki, Y. Does oxidative stress participate in the development of hepatocellular carcinoma?. J Gastroenterol 41, 1135–1148 (2006). https://doi.org/10.1007/s00535-006-1982-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00535-006-1982-z

Key words

Navigation