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A case of deep venous thrombosis associated with pegylated interferon α2b plus ribavirin treatment of chronic hepatitis C

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Abstract

We present a case of deep venous thrombosis (DVT) during pegylated interferon (peg-IFN)-α2b plus ribavirin treatment of chronic hepatitis C (CHC). A 67-year-old man, who had been under treatment for hypertension and diabetes mellitus, was admitted to our hospital for peg-IFN-α2b plus ribavirin treatment for CHC. His serum hepatitis C virus (HCV) RNA level became undetectable 1 week after the initiation of peg-IFN-α2b plus ribavirin treatment. He suffered from severe pain, flare, and edema in both of his lower legs 6 weeks after the initiation of peg-IFN-α2b plus ribavirin treatment. He was diagnosed as having DVT because of the presence of a thrombus in the right soleus vein by ultrasonography. Peg-IFN-α2b plus ribavirin treatment was discontinued because a causal relationship between DVT and peg-IFN-α2b plus ribavirin treatment was suspected. DVT was not observed and the symptoms in both of his legs were improved after the administration of warfarin potassium. Subsequently, DVT has not recurred, and he has remained HCV-RNA negative.

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Authors and Affiliations

  1. Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, 216-8511, Japan

    Chiaki Okuse, Kayo Adachi, Yoshiki Katakura, Kotaro Matsunaga, Toshiya Ishii, Nobuyuki Matsumoto, Michihiro Suzuki & Fumio Itoh

  2. Division of Infectious Diseases, Department of Internal Medicine, University of Tokyo, Tokyo, Japan

    Hiroshi Yotsuyanagi

  3. Research Center for Liver Disease, Kiyokawa Medical Center, Tokyo, Japan

    Shiro Iino

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  1. Chiaki Okuse
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  2. Kayo Adachi
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  3. Yoshiki Katakura
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  4. Kotaro Matsunaga
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  9. Michihiro Suzuki
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Okuse, C., Adachi, K., Katakura, Y. et al. A case of deep venous thrombosis associated with pegylated interferon α2b plus ribavirin treatment of chronic hepatitis C. J Gastroenterol 41, 1231–1236 (2006). https://doi.org/10.1007/s00535-006-1910-2

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  • DOI: https://doi.org/10.1007/s00535-006-1910-2

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