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Molecular genetics of intraductal papillary–mucinous neoplasms of the pancreas

  • Topics: Current understanding of precursors to pancreatic cancer
  • Published:
Journal of Hepato-Biliary-Pancreatic Surgery

Abstract

Intraductal papillary–mucinous neoplasms of the pancreas show characteristic clinicopathological and molecular pathobiological features which are distinct from those of conventional ductal adenocarcinomas. Alterations of KRAS, AKT/PKB, CDKN2A, TP53, SMAD4, STK11/LKB1, and DUSP6, and other molecular alterations, including global expression studies as well as their clinical implications, are discussed.

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  1. International Research and Educational Institute for Integrated Medical Sciences, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan

    Toru Furukawa

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Furukawa, T. Molecular genetics of intraductal papillary–mucinous neoplasms of the pancreas. J Hepatobiliary Pancreat Surg 14, 233–237 (2007). https://doi.org/10.1007/s00534-006-1167-4

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  • DOI: https://doi.org/10.1007/s00534-006-1167-4

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