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Gallbladder cancer: surgical results after cholecystectomy in 25 patients with lamina propria invasion and 26 patients with muscular layer invasion

  • Published:
Journal of Hepato-Biliary-Pancreatic Surgery

Abstract

Background/Purpose

It has been stated that simple cholecystectomy is sufficient treatment for all patients with pT1 gallbladder cancer. However, other authors note the necessity of carrying out extended surgery when there is muscular-layer involvement.

Methods

A consecutive series of gallbladder carcinomas with lamina propria or muscular layer invasion were analyzed. Between July 1982 and December 2000, 51 patients with pT1 gallbladder carcinomas were treated with simple cholecystectomy (group A, 25 patients with lamina propria-invasion; group B, 26 patients with muscular-layer invasion). Patients with intraepithelial carcinomas were excluded from the study.

Results

There were no differences between the groups in average age, sex ratios, association with other tumors, histologic type, malignancy grade, cholecystitis type, macroscopic aspects, lymph node status, or treatment applied. After an average of 6 years' follow-up, no patients in group A and nine patients (34.6%) in group B died due to gallbladder carcinoma. Cystic lymph nodes could be studied in five of these nine patients who relapsed, and the results were negative for metastasis. Lymphatic or venous invasion was observed in five of these nine patients.

Conclusions

According to these results, cholecystectomy is not sufficient treatment for gallbladder carcinoma with muscular-layer invasion.

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Authors and Affiliations

  1. Surgical Oncology, Hospital del Centenario, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Humboldt 4032, 2000, Rosario, Argentina

    Juan C. Rodríguez Otero

  2. Department of Pathology, Policlínico Pami II Dr. M. Freyre, Rosario, Argentina

    Amalia Proske, Cristina Vallilengua, Marta Luján & Guillermo Celoria

  3. Immunology Institute, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Rosario, Argentina

    Leonor Poletto, Stella M. Pezzotto & Jorgelina Rodríguez Otero

  4. Clinical Oncology, Policlínico Pami II Dr. M. Freyre, Rosario, Argentina

    Luis Fein

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  1. Juan C. Rodríguez Otero
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  2. Amalia Proske
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  3. Cristina Vallilengua
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Rodríguez Otero, J., Proske, A., Vallilengua, C. et al. Gallbladder cancer: surgical results after cholecystectomy in 25 patients with lamina propria invasion and 26 patients with muscular layer invasion. J Hepatobiliary Pancreat Surg 13, 562–566 (2006). https://doi.org/10.1007/s00534-006-1123-3

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  • DOI: https://doi.org/10.1007/s00534-006-1123-3

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