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Retrospective analysis of outcome in 63 gallbladder carcinoma patients after radical resection

  • Original articles
  • Published:
Journal of Hepato-Biliary-Pancreatic Surgery

Abstract

Background/Purpose

The aim of this study was to evaluate factors influencing outcome in gallbladder carcinoma after radical resection, in order to identify those patients benefiting from radical surgery.

Methods

Sixty-three patients (13 pT1, 28 pT2, 14 pT3, and 8 pT4) who underwent surgical resection for gallbladder carcinoma were retrospectively reviewed. Correlations were sought between survival and factors such as the depth of invasion (pT) including the status of infiltration of the hepatoduodenal ligament (pBinf) and liver bed (pHinf), the extent of lymph node metastasis, and other pathologic factors.

Results

Multivariate analysis showed that pBinf, pHinf, and lymph node metastasis were significant prognostic factors. We also analyzed survival rates for each operative procedure. There was no difference in survival between patients with or without bile duct resection for lymph node metastasis. The 5-year survival rates of pHinf-negative patients with stage 1B or more advanced disease after gallbladder bed resection or bisegmentectomy 4a,5 versus those without liver resection were 66% and 0%, respectively. Twelve patients survived for more than 5 years after surgery, including one patient undergoing HPD (liver resection with pancreatoduodenectomy) with positive lymph node metastasis; none was pBinf-positive.

Conclusions

Several factyors were identified as having prognostic significance for survival in patients with gallbladder carcinomas, and we suggest that radical surgery may be indicated for selected patients with advanced disease.

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Authors and Affiliations

  1. Department of Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan

    Hiroshi Yagi, Motohide Shimazu, Shigeyuki Kawachi, Minoru Tanabe, Koichi Aiura, Masakazu Ueda & Masaki Kitajima

  2. First Department of Surgery, Iwate Medical University School of Medicine, Iwate, Japan

    Go Wakabayashi

  3. Nakamura Hospital, Fukui, Japan

    Yasutaka Nakamura

Authors
  1. Hiroshi Yagi
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  2. Motohide Shimazu
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  3. Shigeyuki Kawachi
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  4. Minoru Tanabe
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  7. Masakazu Ueda
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  8. Yasutaka Nakamura
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  9. Masaki Kitajima
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Yagi, H., Shimazu, M., Kawachi, S. et al. Retrospective analysis of outcome in 63 gallbladder carcinoma patients after radical resection. J Hepatobiliary Pancreat Surg 13, 530–536 (2006). https://doi.org/10.1007/s00534-006-1104-6

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  • DOI: https://doi.org/10.1007/s00534-006-1104-6

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