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Factors associated with perceived cognitive impairment in patients with advanced lung cancer: a cross-sectional analysis

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Abstract

Purpose

Perceived cognitive impairment refers to cognitive dysfunction that particularly involves impairment in working or short-term memory, and inattention. This study aimed to identify factors associated with perceived cognitive impairment in patients with advanced lung cancer.

Methods

This cross-sectional analysis used pooled data from a prospective, ongoing randomized controlled trial examining the effectiveness of exercise in patients with advanced lung cancer (Trial Registration: NCT04119778). Patients diagnosed with stage IIIB or IV non-small cell lung cancer were recruited from three public hospitals in Hong Kong between December 2018 and December 2021. Demographics, daily step count, sleep quality, fatigue, depression, anxiety, and perceived cognitive impairment were included in the analyses. Multivariate logistic regression analysis was used to determine the most critical risk factors associated with perceived cognitive impairments in attention and memory.

Results

A total of 226 patients were included and analyzed, 35.4% of patients had perceived attention impairment and 58.4% had perceived memory impairment. The daily step count (adjusted odds ratio [aOR] = 0.496; confidence interval [CI] = 0.258–0.954), fatigue (aOR = 1.342; CI = 1.903–1.648), and anxiety (aOR = 1.179; CI = 1.042–1.335) were associated with a significantly increased risk of perceived attention impairment, while anxiety (aOR = 1.126; CI = 1.008–1.257) was identified as the most significant factor for perceived memory impairment.

Conclusion

The findings of this study can inform the design of effective interventions to reduce perceived cognitive impairment and promote the quality of life and well-being of patients with advanced lung cancer.

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Acknowledgements

We would like to thank Dr. Tai Chung Lam, Dr. Tsz Yeung Kam, Dr. Inda Soong, and Dr. Yin Kwan Chik in the target settings for coordinating participant recruitment, and the participants for participating in the study.

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Author notes

  1. Naomi Takemura and Mu-Hsing Ho contributed equally to this paper and should be considered joint first authors.

Authors and Affiliations

  1. School of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 5/F, Academic Building, 3 Sassoon Road, Pokfulam, Hong Kong

    Naomi Takemura, Mu-Hsing Ho, Denise Shuk Ting Cheung & Chia-Chin Lin

Authors
  1. Naomi Takemura
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  2. Mu-Hsing Ho
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  3. Denise Shuk Ting Cheung
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  4. Chia-Chin Lin
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Contributions

Conceptualization: Naomi Takemura, Mu-Hsing Ho, Denise Shuk Ting Cheung, Chia-Chin Lin.

Methodology: Naomi Takemura, Mu-Hsing Ho, Denise Shuk Ting Cheung, Chia-Chin Lin.

Formal analysis and investigation: Naomi Takemura, Mu-Hsing Ho.

Writing—original draft preparation: Naomi Takemura, Mu-Hsing Ho.

Writing—review and editing: Mu-Hsing Ho, Denise Shuk Ting Cheung, Chia-Chin Lin.

Supervision: Chia-Chin Lin.

All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Chia-Chin Lin.

Ethics declarations

Ethics approval

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the University of Hong Kong/Hospital Authority Hong Kong West Cluster (approval number: UW 18–154), Hong Kong East Cluster (approval number: HKECREC-2019–014), and Kowloon Central Cluster/Kowloon East Cluster (approval number: KC/KE-19–0039/ER-3).

Consent to participate

Informed consent was obtained from all individual participants included in the study.

Consent for publication

Not applicable.

Competing interests

The authors declare no competing interests.

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Takemura, N., Ho, MH., Cheung, D.S.T. et al. Factors associated with perceived cognitive impairment in patients with advanced lung cancer: a cross-sectional analysis. Support Care Cancer 30, 9607–9614 (2022). https://doi.org/10.1007/s00520-022-07377-9

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  • DOI: https://doi.org/10.1007/s00520-022-07377-9

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