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Fatigue among post–hematopoietic stem cell transplant patients in Jordan: prevalence and associated factors

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Abstract

Background

During hematopoietic stem cell transplant (HSCT), patients underwent various serious prolonged treatments, including conditioning and immunosuppressive drugs, resulting in several symptoms and alterations in the patient’s functioning. One of the most commonly reported symptoms is fatigue.

Aim

To assess fatigue levels and associated factors during the first 100 days post-HSCT among Jordanian patients.

Methods

A descriptive cross-sectional design assessed fatigue and associated factors during the first 100 days post-HSCT among Jordanian patients. A convenient sample was used to recruit post-HSCT patients. Data were collected using the demographic survey and the Brief Fatigue Inventory (BFI) scale.

Results

The findings of this study demonstrated that 40.5% of the participants had severe total fatigue scores, while the mean BFI intensity average score was 5.01 and the mean interference of fatigue with patients’ daily life was 5.06. In terms of fatigue interference with daily activities, the highest interference was with the patient’s mood and normal work, while the lowest interference was with the walking ability. The analysis revealed a strong positive correlation between the fatigue intensity and its interference with the daily activities (r = .98, p ˂.001). Besides, a significantly strong negative correlation was found between the number of days post-HSCT and fatigue scores (r =  − .92, p ˂.001).

Conclusion

Post-transplant, patients experienced increased fatigue intensity, reduced physical activity, interference with the patient’s mood, and diminished functional capacity. Patients who have HSCT require a significant nursing care immediately post-transplant.

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Data Availability

The data that support the findings of this study are available within the article.

Code availability

Not applicable.

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Acknowledgements

The authors would like to thank all of the participants.

Author information

Authors and Affiliations

  1. Nursing Department, King Hussein Cancer Center, Amman, Jordan

    Osama Abdalkareem Abdalrahman

  2. Faculty of Nursing, Applied Science Private University, Amman, Jordan

    Elham H. Othman

  3. Faculty of Nursing, Zarqa University, P.O.Box 132222, Zarqa, 13132, Jordan

    Anas H. Khalifeh

  4. Faculty of Nursing, Al-Zaytoonah University, P.O. Box 130, Amman, 11733, Jordan

    Khaled Hasan Suleiman

Authors
  1. Osama Abdalkareem Abdalrahman
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  2. Elham H. Othman
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  3. Anas H. Khalifeh
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  4. Khaled Hasan Suleiman
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Contributions

All authors discussed the results and contributed to the final manuscript. Data collection was performed and critical feedback was provided by Osama Abdalkareem Abdalrahman and Khaled Hasan Suleiman. Study conception and design, and data analysis and interpretation were completed by Osama Abdalkareem Abdalrahman, Elham H. Othman, and Anas H. Khalifeh. Review of the result and preparation of tables were completed by Anas H. Khalifeh, Elham H. Othman, and Khaled Hasan Suleiman. The first draft of the article was written by Elham H. Othman, Anas H. Khalifeh, and Osama Abdalkareem Abdalrahman. Critical revision of the article and help in shaping the research were done by Anas H. Khalifeh and Elham H. Othman, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Osama Abdalkareem Abdalrahman.

Ethics declarations

Ethics approval

This study was approved by the Institutional Review Board (IRB) of King Hussein Cancer Center (KHCC) (No. 20 KHCC 63/Date 3–13-2020). This study was performed in line with the principles of the Declaration of Helsinki.

Consent to participate

The eligible participants signed informed consent before data collection; they were assured that their participation was voluntary and they could withdraw from the study at any time without affecting their treatment.

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Not applicable.

Competing interests

The authors declare no competing interests.

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Abdalrahman, O.A., Othman, E.H., Khalifeh, A.H. et al. Fatigue among post–hematopoietic stem cell transplant patients in Jordan: prevalence and associated factors. Support Care Cancer 30, 7679–7687 (2022). https://doi.org/10.1007/s00520-022-07186-0

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  • DOI: https://doi.org/10.1007/s00520-022-07186-0

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