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Association between cardiac autonomic modulation and sedentary behavior in breast cancer survivors: a 12-month cohort study

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Abstract

Purpose

This study aimed to analyze the longitudinal influence of sitting time (ST) on cardiac autonomic modulation (CAM) and resting heart rate (RHR) in a 12-month cohort of 67 breast cancer survivors.

Methods

CAM was assessed by heart rate variability with heart monitor which also assessed RHR, and ST was self-reported. The relationship between the variables was analyzed by the Pearson correlation and its magnitude by linear regression.

Results

At baseline, no associations were found between ST and CAM or RHR. In the delta analyses, a decrease in RMSSD, SD1, and HF(ms2) was associated with sitting time. At 12-month follow-up, there was an increase in the ST and a decrease in RHR. ST was negatively related with CAM (RMSSD, PNN50, and SD1), but no association was observed between ST and RHR.

Conclusion

The increase in ST was associated with worsening of CAM after 12-month follow-up. Promoting reduction in ST will be an important strategy against cardiovascular impairment in breast cancer survivors.

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Data Availability

Data will be available by the authors after a justified request.

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Funding

This study was supported by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Brazil.

Author information

Authors and Affiliations

  1. Sao Paulo State University (UNESP), SP, Presidente Prudente, Brazil

    Mariana R. Palma, Luiz Carlos M. Vanderlei, Cristina E. P. T. Fregonesi, Fernanda E. Ribeiro, Daniela T. Caldeira & Diego G. D. Christofaro

  2. Assis’s Municipal Institute of Higher Education, SP, Assis, Brazil

    Mariana R. Palma

  3. Center of Clinical and Epidemiological Research, Hospital Universitário, Universidade de São Paulo, Sao Paulo, Brazil

    William R. Tebar

  4. Post-graduate Program in Rehabilitation Sciences, Universidade Nove de Julho, Sao Paulo, SP, Brazil

    Raphael M. Ritti-Dias

Authors
  1. Mariana R. Palma
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  2. William R. Tebar
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  3. Luiz Carlos M. Vanderlei
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  4. Cristina E. P. T. Fregonesi
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  5. Fernanda E. Ribeiro
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  6. Daniela T. Caldeira
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  7. Raphael M. Ritti-Dias
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  8. Diego G. D. Christofaro
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Contributions

Conception and design: MRP, LCMV, CEPTF, and DGDC; data collection: MRP, FER, and DTC; data analysis: MRP, WRT, RMRT, and DGDC; writing and review: MRP, WRT, RMR, and DGDC; final version approval: all authors.

Corresponding author

Correspondence to William R. Tebar.

Ethics declarations

Ethics approval

This study was approved by the Research Ethics Committee of FCT/UNESP (CAAE: 54169416.6.0000.5402).

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A consent form was signed by all the participants.

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Not applicable/no personal information will be published.

Conflict of interest

The authors declare no competing interests.

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Palma, M.R., Tebar, W.R., Vanderlei, L.C.M. et al. Association between cardiac autonomic modulation and sedentary behavior in breast cancer survivors: a 12-month cohort study. Support Care Cancer 30, 1873–1878 (2022). https://doi.org/10.1007/s00520-021-06602-1

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  • DOI: https://doi.org/10.1007/s00520-021-06602-1

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