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Factors influencing early postoperative health-related quality of life in patients with alimentary system cancer

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Abstract

Purpose

The purpose of this study was to investigate changes in early postoperative health-related quality of life (HRQOL) in patients with gastrointestinal cancer and to examine the factors influencing such changes.

Methods

Participants were 106 patients scheduled for elective surgery for gastrointestinal cancer (61 male and 45 females; aged 62.6 ± 12.0 years). HRQOL was evaluated using the Short-Form 36-Item Health Survey version 2 (SF-36) at two time points: 1–2 days prior to surgery (baseline) and 4 weeks after surgery. Clinical and social characteristics based on previous studies were investigated as potential factors influencing changes in early postoperative HRQOL.

Results

Physical functioning, physical role functioning, bodily pain, vitality, social role functioning, and emotional role functioning significantly decreased at 4 weeks after surgery compared with baseline. Mental health at 4 weeks after surgery significantly improved compared with baseline. The scores on each SF-36 subscale at 4 weeks after surgery were significantly associated with gender, clinical stage of cancer, neoadjuvant therapy, surgical site, postoperative complications, HRQOL at baseline, and 6-min walk test at 4 weeks after surgery.

Conclusion

To increase early postoperative HRQOL in surgical patients with gastrointestinal cancer, it may be necessary to not only improve postoperative management but also increase exercise capacity after surgery and HRQOL before surgery.

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Data availability

The authors have full control of all primary data and we agree to allow the journal to review the data if required.

Code availability

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Acknowledgements

The authors thank the rehabilitation staff at the International University Health and Welfare Mita Hospital for their help with data collection.

Funding

The Grants-in-Aid for Scientific Research funded this study (grant number: 19K19880) from the Japan Society for the Promotion of Science.

Author information

Authors and Affiliations

  1. Department of Physical Therapy, School of Health Science, International University of Health and Welfare, Tochigi, Japan

    Tsuyoshi Hara & Akira Kubo

  2. Rehabilitation Progress Center Incorporated, Tokyo, Japan

    Eisuke Kogure

Authors
  1. Tsuyoshi Hara
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  2. Eisuke Kogure
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  3. Akira Kubo
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Contributions

All authors contributed to the study conception and design. Tsuyoshi Hara, Eisuke Kogure, and Akira Kubo performed material preparation, data collection, and analysis. The first draft of the manuscript was written by Tsuyoshi Hara and all authors commented on the previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Tsuyoshi Hara.

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Ethics approval

The study was approved by the Research Ethics Board of the International University Health and Welfare Mita Hospital, Minato-ku, Tokyo, Japan. All study procedures were carried out in accordance with ethical standards (Registration no. 5-15-1) as well as the Declaration of Helsinki.

Consent to participate

All the participants were informed about the research and agreed to participate voluntarily.

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Not applicable

Conflict of interest

The authors declare no competing interests.

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Hara, T., Kogure, E. & Kubo, A. Factors influencing early postoperative health-related quality of life in patients with alimentary system cancer. Support Care Cancer 29, 6145–6154 (2021). https://doi.org/10.1007/s00520-021-06187-9

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  • DOI: https://doi.org/10.1007/s00520-021-06187-9

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