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A systematic review on chronic oxaliplatin-induced peripheral neuropathy and the relation with oxaliplatin administration

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Abstract

Purpose

The aim of this study was to systematically review the literature on the influence of oxaliplatin administration (e.g. cumulative dose, dose intensity, number of cycles and combination regimen) on the long-term prevalence of oxaliplatin-induced peripheral neuropathy (O-IPN) at least 12 months after termination of chemotherapy.

Methods

A computerized search of literature on databases PubMed and Cochrane was performed. Published original articles were included if they reported about long-term O-IPN and gave concomitant information about oxaliplatin therapy given to the patients. All articles were assessed for quality.

Results

We included 14 articles (n = 3,869 patients), and the majority of these studies were of high quality. All included patients who were treated for colorectal cancer, mainly with oxaliplatin in combination with 5-fluorouracil/leucovorin. Median cumulative doses and dose intensity varied between 676 and 1,449 mg/m2 and 30.8 and 42.6 mg/m2/week, respectively. Neuropathy assessment differed between studies, and the National Cancer Institute-Common Terminology Criteria (NCI-CTC) was used most often. The degree of neuropathy ranged from grade 0 to 3. Only six studies directly assessed the relationship between oxaliplatin administration and neuropathy. Of these studies, five did find a relation between neuropathy and higher cumulative dose, while one study did not find a relation.

Conclusions

O-IPN is still present in a great amount of patients in ≥12 months after termination of therapy. A higher cumulative dose is likely to have an influence on the development of long-term O-IPN. More studies are needed that assess long-term neuropathy and oxaliplatin administration by means of validated neuropathy assessments.

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Acknowledgments

Floortje Mols was supported by a VENI grant (no. 451-10-041) from the Netherlands Organization for Scientific Research (The Hague, The Netherlands).

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Authors and Affiliations

  1. Department of Internal Medicine, Máxima Medical Centre, PO Box 7777, 5500 MB, Veldhoven, The Netherlands

    A. J. M. Beijers & G. Vreugdenhil

  2. Center of Research on Psychology in Somatic Diseases (CoRPS), Department of Medical and Clinical Psychology, Tilburg University, Tilburg, The Netherlands

    F. Mols

  3. Comprehensive Cancer Centre Netherlands (CCCN), Eindhoven Cancer Registry, Eindhoven, The Netherlands

    F. Mols

  4. Department of Medical Oncology, Maastricht University Medical Centre, Maastricht, The Netherlands

    G. Vreugdenhil

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  1. A. J. M. Beijers
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Correspondence to G. Vreugdenhil.

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The manuscript has been prepared in accordance with the style of the journal, and all authors have approved of its contents. This manuscript is not being considered for publication elsewhere, and the findings of this manuscript have not been previously published. There is no conflict of interest.

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Beijers, A.J.M., Mols, F. & Vreugdenhil, G. A systematic review on chronic oxaliplatin-induced peripheral neuropathy and the relation with oxaliplatin administration. Support Care Cancer 22, 1999–2007 (2014). https://doi.org/10.1007/s00520-014-2242-z

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