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Patient-reported outcomes for patients undergoing radical cystectomy: a prospective case–control study

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Abstract

Purpose

The purpose of this study was to measure patient-reported outcomes (PROs) for patients with muscle-invasive bladder cancer (BC) before the diagnosis of BC was known, thus before cystectomy, and until 1 year postcystectomy. The differences in outcomes between a health status (HS) and quality of life (QoL) questionnaires were examined.

Methods

From July 2007 to July 2010, 598 patients with primary hematuria were enrolled in this prospective, multi-centre case–control (CC) study. Patients undergoing radical cystectomy (RC; N = 18) were compared with patients with other causes of hematuria (CC, N = 20). Measurement points were before diagnosis as well as 3, 6 and 12 months postcystectomy. Questionnaires used were the WHOQOL-BREF, SF-12, International Index of Erectile Function, and 10-item STAI-Trait scale.

Results

Prediagnosis patients who later appeared to have BC had the same QoL compared to CC patients. The prediagnosis physical component scale of HS and sexual function were significantly lower for RC vs. CC patients. RC patients had a better prediagnostic QoL and HS than postcystectomy at all time points.

Conclusions

This is the first case–control study with a baseline measurement of PROs before the diagnosis of BC was known. It shows lower physical health and sexual function for RC vs. CC before diagnosis is known. Until 1 year postcystectomy, QoL does not return to baseline level. Future studies including comorbidity and smoking history are needed to examine the generalizability of our results.

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Acknowledgments

The authors would like to thank Mrs. Yvonne de Vuijst, research nurse, for the help with the data collection and the administration involved in this study. In addition, our gratitude goes to the participating hospitals (University Medical Centre Utrecht; St. Elisabeth Hospital and TweeSteden Hospital, Tilburg; Onze Lieve Vrouwe Gasthuis, Amsterdam; Jeroen Bosch Hospital, ‘s Hertogenbosch; Catharina Hospital, Eindhoven) for patient inclusion.

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Authors and Affiliations

  1. Department of Urology, University Medical Centre Utrecht, Utrecht, The Netherlands

    Catharina A. Goossens - Laan & J. L. H. Ruud Bosch

  2. Department of Urology, St. Elisabeth Hospital, Tilburg, The Netherlands

    Paul J. M. Kil

  3. Department of Medical Psychology, St. Elisabeth Ziekenhuis, Tilburg University, Tilburg, The Netherlands

    Jolanda De Vries

  4. Department of Urology, Rijnland Hospital, Leiderdorp, The Netherlands

    Catharina A. Goossens - Laan

  5. CoRPS, Tilburg University, Tilburg, The Netherlands

    Jolanda De Vries

Authors
  1. Catharina A. Goossens - Laan
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  2. Paul J. M. Kil
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  3. J. L. H. Ruud Bosch
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  4. Jolanda De Vries
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Correspondence to Catharina A. Goossens - Laan.

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Goossens - Laan, C.A., Kil, P.J.M., Bosch, J.L.H.R. et al. Patient-reported outcomes for patients undergoing radical cystectomy: a prospective case–control study. Support Care Cancer 22, 189–200 (2014). https://doi.org/10.1007/s00520-013-1946-9

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  • DOI: https://doi.org/10.1007/s00520-013-1946-9

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