Abstract
Introduction
To assess the efficacy of Shakuyaku-Kanzo-to, a Japanese herbal medicine, for prophylaxis against paclitaxel-induced myalgia and arthralgia, a comparative study was conducted with 50 patients treated with carboplatin and paclitaxel.
Patients and Methods
Patients were alternatively assigned to receive either the intervention group (with Shakuyaku-Kanzo-to) or the control group (without Shakuyaku-Kanzo-to). We assessed the grade and the duration of myalgia and arthralgia.
Results
The grades of myalgia and arthralgia in the control group were significantly higher than the grades determined in the intervention group (p = 0.018). The mean duration of myalgia and arthralgia was 2.78 ± 2.09 days for the intervention group and 5.08 ± 2.89 days for the control group. The duration was significantly shorter in the intervention group than in the control group (p = 0.002).
Discussion
This study shows that prophylactic administration of Shakuyaku-Kanzo-to was effective against paclitaxel-induced myalgia and arthralgia.
Similar content being viewed by others
References
Boyle FM, Monk R, Davey R et al (1996) Prevention of experimental paclitaxel neuropathy with glutamate. Proc AACR 37(Abstr #1974):290
Brystol-Myers Squibb (1996) Taxol (paclitaxel) injection prescribing information. Brystol-Myers Squibb, Princeton, pp 1–6
Fujii K, Okamoto S, Saitoh K, Sasaki N, Takano M, Tanaka S (2004) The efficacy of Shakuyaku-Kanzo-to for peripheral nerve dysfunction in paclitaxel combination chemotherapy for epithelial ovarian carcinoma. Gan To Kagaku Ryoho 31(10):1537–1540
Hotta K, Matsuo K, Ueoka H, Kiura K, Tabata M, Tanimoto M et al (2004) Meta-analysis of randomized clinical trials comparing cisplatin to carboplatin in patients with advanced non-small-cell lung cancer. JCO 2004:3852–3859
Moriyama T, Higashi T, Yogashi K, Iida T, Segi E, Sugimoto Y et al (2005) Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins. Mol Pain 1(1):3. doi:10.1186/1744-8069-1-3
Murata T, Ushikabi F, Matsuoka T, Hirata M, Yamasaki A, Sugimoto Y et al (1997) Alterd pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature 388:678–682. doi:10.1038/41780
Non-small Cell Lung Cancer Collaborative Group (1995) Chemotherapy in non-small cell lung cancer: A meta-analysis using updated data on individual patients from 52 randomized clinical trials. BMJ 311:899–909
Oho Y, Ohashi Y, Kubota K et al (2007) Randomized phase III study of cisplatin plus irinotecan versus carboplatin plus paclitaxel, cisplatin plus gemcitabine, and cisplatin plus vinorelbine for advanced non-small cell lung cancer: Four-Arm Cooperative Study in Japan. Ann Oncol 18(2):317–323. doi:10.1093/annonc/mdl377
Ohuchi K, Kamada Y, Levine L, Tsurufuji S (1981) Glycyrrhizin inhibits prostaglandin E2 production by activated peritoneal macrophages from rats. Prostaglandins Med 7(5):457–463. doi:10.1016/0161-4630(81)90033-1
Rowinsky EK, Donehower RC, Jones RJ, Tucker RW (1988) Microtubule changes and cytotoxicity in leukemic cell line treated with Taxol. Cancer Res 48:4093–4100
Samad TA, Sapirstein A, Woolf CJ (2002) Prostanoids and pain: unraveling mechanisms and revealing therapeutic targets. Trends Mol Med 8:390–396. doi:10.1016/S1471-4914(02)02383-3
Schiff PB, Horwitz SB (1981) Taxol assembles tubulin in the absence of exogenous guanosine 5’-triphosphate or microtubule-associated proteins. Biochemistry 20:3247–3252. doi:10.1021/bi00514a041
Shiki Y, Ishihara Y, Shirai K, Saito Y, Yoshida S (1986) Effect of glycyrrhizin on lysosomes labilization by phospholipase A2. Am J Chin Med 14:131–137. doi:10.1142/S0192415X86000211
Van Deventer H, Bernard S (1999) Use of gabapentin to treat taxan-induced myalgia. J Clin Oncol 17(1):434–435
Yana T, Takada M, Origasa H, Ijima T, Yamamoto N, Nakagawa K (2002) New chemotherapy agent plus platinum for advanced non-small cell lung cancer: a meta-analysis. Proc Am Soc Clin Oncol 21:328a
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Yoshida, T., Sawa, T., Ishiguro, T. et al. The Efficacy of prophylactic Shakuyaku-Kanzo-to for myalgia and arthralgia following Carboplatin and Paclitaxel combination chemotherapy for non-small cell lung cancer. Support Care Cancer 17, 315–320 (2009). https://doi.org/10.1007/s00520-008-0508-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00520-008-0508-z