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Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage

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Abstract

Intestinal mucositis occurs as a consequence of cytotoxic treatment through multiple mechanisms including induction of crypt cell death (apoptosis) and cytostasis. The molecular control of these actions throughout the gastrointestinal tract has yet to be fully elucidated; however, they are known to involve p53, the Bcl-2 family and caspases. This review will provide an overview of current research as well as identify areas where gaps in knowledge exist.

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  1. Department of Medical Oncology, Royal Adelaide Hospital, North Terrace, Adelaide, 5000, South Australia, Australia

    Joanne M. Bowen, Rachel J. Gibson & Dorothy M. K. Keefe

  2. Department of Medicine, University of Adelaide, Adelaide, South Australia, Australia

    Joanne M. Bowen, Rachel J. Gibson, Adrian G. Cummins & Dorothy M. K. Keefe

  3. Department of Gastroenterology and Hepatology, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia

    Adrian G. Cummins

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Bowen, J.M., Gibson, R.J., Cummins, A.G. et al. Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage. Support Care Cancer 14, 713–731 (2006). https://doi.org/10.1007/s00520-005-0004-7

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