Abstract
To determine whether radiotherapy is effective for reducing morphine dose in patients with bone metastasis from lung cancer, a retrospective study was undertaken of 58 patients who had undergone palliative radiotherapy. Mean dose of radiotherapy was 20.26 (range 8–60) Gy. Daily morphine dose after start of radiotherapy was significantly greater than before radiotherapy, and dose of morphine did not significantly decrease. Radiotherapy appears ineffective for reducing morphine dose in patients with bone metastasis from lung cancer.
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References
Allard P, Lamontagne C, Bernard P, et al (1999) How effective are supplementary doses of opioids for dyspnea in terminally ill cancer patients? A randomized continuous sequential clinical trial. J Pain Symptom Manage 17:256–265
Falkmer U, Jarhult J, Wersall P, et al (2003) A systematic overview of radiation therapy effects in skeletal metastases. Acta Oncol 42:620–633
Jeremic B, Shibomoto Y, Acimovic L, et al (1998) A randomized trial of three single-dose radiation therapy regimens in the treatment of metastatic bone pain. Int J Radiation Oncology Biol Phys 42:161–167
Nielsen OS, Bentzen SM, Sandberg E, et al (1998) Randomized trial of single dose versus fractionated palliative radiotherapy of bone metastases. Radiother Oncol 47:233–240
Ratanatharathorn V, Powers WE, Moss WT, et al (1999) Bone metastasis: review and critical analysis of random allocation trials of local field treatment. Int J Radiation Oncology Biol Phys 44:1–18
Shakespeare TP, Lu JJ, Back MF, et al (2003) Patient preference for radiotherapy fractionation schedule in the palliation of painful bone metastases. J Clin Oncol 21:2156–2162
Sze WM, Shelley MD, Held I, et al (2003) Palliation of metastatic bone pain: single fraction versus multifraction radiotherapy—a systematic review of randomised trials. Clin Oncol (R Coll Radiol) 15: 345–352
World Health Organization (1996) Cancer pain relief, 2nd edn. World Health Organization, Geneva [Suppl 2]
Wu JSY, Wong R, Johnston M, et al (2003) Meta-analysis of dose-fractionation radiotherapy trials for the palliation of painful bone metastases. Int J Radiation Oncology Biol Phys 55:594–605
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Ishiyama, H., Shibata, A., Niino, K. et al. Relationship between morphine and radiotherapy for management of symptomatic bone metastases from lung cancer. Support Care Cancer 12, 743–745 (2004). https://doi.org/10.1007/s00520-004-0625-2
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DOI: https://doi.org/10.1007/s00520-004-0625-2