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Orosomucoid is an independent predictor of prognosis in chronic heart failure

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Summary

Background

Heart failure is associated with low-grade inflammation. In the present study we sought to assess the prognostic impact of orosomucoid, a marker of inflammation, in outpatients with heart failure.

Methods

In outpatients with chronic heart failure (no change in clinical status and/or therapy >3 months prior to inclusion), baseline levels of orosomucoid were determined. Clinical follow-up was obtained and the rate of heart failure-related deaths and hospitalisations recorded.

Results

A total of 134 patients (median age 71, 33.3 % female, mean left ventricular ejection fraction [LVEF] 36 %) were included. During a median follow-up of 695 (456–811) days, 54 patients (40.1 %) experienced an event. On Cox multivariate analysis, orosomucoid levels above the median (>497 mg/l) emerged as an independent predictor of prognosis (hazard ratio = 2.86, 95 % confidence interval 1.48–5.52 after adjusting for age, gender, ischaemic vs. non-ischaemic aetiology, LVEF, NT-proBNP and NYHA class).

Conclusion

Orosomucoid levels are an independent predictor of heart failure-related mortality and hospitalisations in patients with chronic heart failure.

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Authors and Affiliations

  1. Ljubljana, Slovenia

    Petra Kaplan MD,  Bojan Vrtovec MD PhD &  Borut Jug MD PhD

Authors
  1. Petra Kaplan MD
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  2. Bojan Vrtovec MD PhD
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  3. Borut Jug MD PhD
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Corresponding author

Correspondence to Petra Kaplan MD.

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Conflict of interest

P. Kaplan, B. Vrtovec and B. Jug declare that they have no competing interests.

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Kaplan, P., Vrtovec, B. & Jug, B. Orosomucoid is an independent predictor of prognosis in chronic heart failure. Wien Klin Wochenschr 128, 870–874 (2016). https://doi.org/10.1007/s00508-016-1034-5

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  • DOI: https://doi.org/10.1007/s00508-016-1034-5

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