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Correlation of tumor-associated macrophages and NK cells with bladder cancer size and T stage in patients with solitary low-grade urothelial carcinoma

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Summary

Objective

The aim of the present study was to correlate the level of tumor-infiltrating immune cells with bladder cancer size and T category in patients with solitary low-grade non-muscle invasive bladder cancer (NMIBC).

Patients and methods

Between 1996 and 2006, 115 patients with solitary low-grade NMIBC after transurethral resection of the bladder without adjuvant therapy were retrospectively identified from the institutional database. Tumor specimens were retrieved and tissue microarrays were constructed. Immunhistochemical staining for tumor-infiltrating immune cells with anti-CD3, CD4, CD8, CD20, CD56, CD68, and granzyme B (Gr B) was performed.

Results

Immune cells were predominantly observed within the cancer stroma. Statistically significant higher levels of CD56 cells in small tumors and CD68 cells in T1 tumors (p = 0.0310, 0.0151, respectively) were established.

Conclusion

The current study propose a possible correlation of CD56+ and CD68+ cells with bladder cancer size and stage in patients with solitary low-grade NMIBC.

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Acknowledgments

We would like to express our gratitude to Ozren Štanfel, Ankica Brajenić, and Ivan Dašek for excellent technical assistance.

Conflict of interest

The authors declare that there are no actual or potential conflicts of interest in relation to this article.

Author information

Authors and Affiliations

  1. Department of Urology, Clinical Hospital Center Rijeka, Tome Strižića 3, 51000, Rijeka, Croatia

    Kristian Krpina MD, PhD, FEBU & Josip Španjol

  2. Department of Pathology, School of Medicine, University of Rijeka, Braće Branchetta 20, 51000, Rijeka, Croatia

    Emina Babarović, Gordana Đorđević & Nives Jonjić

  3. Department of Urology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, München, Germany

    Tobias Maurer

Authors
  1. Kristian Krpina MD, PhD, FEBU
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  2. Emina Babarović
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  3. Josip Španjol
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  4. Gordana Đorđević
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  5. Tobias Maurer
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  6. Nives Jonjić
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Correspondence to Kristian Krpina MD, PhD, FEBU.

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Krpina, K., Babarović, E., Španjol, J. et al. Correlation of tumor-associated macrophages and NK cells with bladder cancer size and T stage in patients with solitary low-grade urothelial carcinoma. Wien Klin Wochenschr 128, 248–252 (2016). https://doi.org/10.1007/s00508-015-0907-3

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  • DOI: https://doi.org/10.1007/s00508-015-0907-3

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