Summary
Background
The aim of the study was to evaluate patients attitudes with benign prostatic hyperplasia at the risk of progression during a 12-month period of observation.
Materials and methods
A total of 426 patients from 45 outpatients centers were included and prospectively followed. Inclusion criteria were: age > 50 years, International Prostate Symptom Score (IPSS) > 8, prostate volume > 30 cm3 (transabdominal ultrasound) and PSA > 1.5 to < 10 ng/ml.
Results
In all, 28.6 % patients were naive, 62.9 % used monotherapy (alpha-blocker), and 8.5 % combined treatment (alpha-blocker/5alpha-reductase inhibitor/dutasteride). The most bothersome symptoms were the weak urine stream (60.8 %) and nocturia (59.2 %). Patients expectations from the treatment were stabilization of the disease and reducing the risk of surgery rather than rapid resolution of symptoms. Despite the presence of symptoms, 2.3 % patients claimed that benign prostatic hyperplasia/lower urinary tract symptoms had no impact on their quality of life (QoL), in 48.1 % only little impact on QoL, and 47.9 % patients percepted their symptoms as severe. Out of 71.4 % patients treated previously, 26.5 % patients were indecisive about the satisfaction of present treatment. Visual analog score was percepted more optimistically rather than the IPSS. Pearsonʼs correlation r = 0.68 at the beginning and r = 0.83 at the end of the study.
Conclusions
Prostate and Expectations of Treatment Epidemiology Research study highlights and reflects on patients behavior and self-perception, patients self-perception of the disease and therapeutic priorities during the 1 year of observation.
Zusammenfassung
Hintergrund
Das Ziel dieser 1-Jahres-Studie war die Evaluation der Patientenwahrnehmung von Miktionsbeschwerden (LUTS) infolge benigner Prostatahyperplasie und die Erwartungen an die medikamentöse Therapie.
Material und Methoden
Es wurden prospektiv 426 Patienten aus 45 ambulanten Zentren in diese Studie eingeschlossen. Die Einschlusskriterien waren: Alter > 50 Jahre, IPSS > 8, Prostatavolumen > 30 cm3 und ein PSA-Wert zwischen 1,5 und 10 ng/ml.
Ergebnisse
Von den 426 Patienten waren 28,6 % behandlungsnaiv, 62,9 % verwendeten eine Monotherapie mit einem Alpha-Blocker und 8,5 % eine Kombinationstherapie mit einem Alpha-Blocker und einem 5-Alpha-Reduktase-Hemmer (Dutasterid). Die vom Patienten als unangenehmsten empfundenen LUTS waren der schwache Harnstrahl (60,8 %) und die Nykturie (59,2 %). Die Patienten erwarteten von der medikamentösen Therapie eher eine Stabilisierung der LUTS und eine Verringerung des Risikos einer Operation als eine schnelle Linderung der LUTS. Bei 47,4 % der Patienten führten LUTS zu einer hochgradigen Verschlechterung der Lebensqualität.
Schlussfolgerungen
Die vorliegende 1-Jahres-Studie reflektiert die Wahrnehmung von LUTS und die Erwartungen des Patienten an die Therapie.
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Acknowledgments
The study was funded by an unconditional research grant from GlaxoSmithKline Inc., Slovakia, which played a role in conducting the study as well as the data collection.
Conflicts of interest
Danica Fackovcova, MD, is a scientific consultant to GlaxoSmithKline-Slovakia. All other authors have no conflict of interest.
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Weibl, P., Klatte, T., Laurinc, P. et al. Patient’s behavior and attitudes toward the management of benign prostatic hyperplasia among patients with the risk of disease progression: prospective study by “Prostate and Expectations of Treatment Epidemiology Research (PETER) study group”. Wien Klin Wochenschr 127, 363–368 (2015). https://doi.org/10.1007/s00508-014-0668-4
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DOI: https://doi.org/10.1007/s00508-014-0668-4