Zusammenfassung
Eine umfassende, repräsentative Basisuntersuchung über Malaria wurde in einer Flüchtlingspopulation im Distrikt Gulu im Norden Ugandas durchgeführt. Die Studie schloss 74 Haushalte und 390 Personen ein. Die erfassten Parameter erstreckten sich auf sozio-ökonomische Information, Umwelt, individuelle physische Daten, Malaria und die Arzneimittelempfindlichkeit von Plasmodium falciparum. Die Prävalenz von Infektionen mit Plasmodium falciparum betrug 54.4% mit einer mittleren asexuellen Parasitämie von 229/µl Blut, ein Hinweis auf hyperendemischen Status. P. falciparum zeigte hochgradige Resistenz gegen Chloroquin und Amodiaquin und bereits reduzierte Sensibilität gegenüber Lumefantrin und Artemisinin, offensichtlich das Resultat freizügigen Einsatzes der Lumefantrin-Artemether Kombination ohne die Basis evidenzgesteuerter Indikation.
Summary
A comprehensive, representative malaria survey has been carried out in a population of internally displaced persons (IDP) in the district of Gulu, Northern Uganda. It included 74 households and 390 persons, and covered socio-economic and environmental information, individual physical data, malaria and the drug sensitivity of Plasmodium falciparum. The prevalence of infections with Plasmodium falciparum was 54.4% at a geometric mean asexual parasitaemia of 229/µl blood, typical for hyperendemic conditions. P. falciparum turned out to be highly resistant to chloroquine and amodiaquine. It showed also reduced sensitivity against lumefantrine and artemisinin, obviously the result of the liberal use of the lumefantrine-artemether combination without evidence-based indication.
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References
World Health Organisation (2006) Health Action in Crises: 2006 Strategy Paper. Geneva
World Health Organisation (2004) Uganda: Last Update. Geneva; www.who.int/disasters/repo/15110.pdf. Last assessed: 2008-02-12
World Health Organisation (2005) Health and mortality survey among internally displaced persons in Gulu, Kitgum and Pader districts, Northern Uganda. Geneva
Accorsi S, Fabiani M, Lukwiya M, Onek PA, Di Mattei P, Declich S (2001) The increasing burden of infectious diseases on hospital services at St Mary's Hospital Lacor, Gulu, Uganda. Am J Trop Med Hyg 64: 154–158
Miller LH, Baruch DI, Marsh K, Doumbo OK (2002) The pathogenic basis of malaria. Nature 415: 673–679
Onori E (1967) Distribution of Plasmodium ovale in the eastern, western and northern regions of Uganda. Bull World Health Organ 37: 665–668
Kolaczinski JH, Ojok N, Opwonya J, Meek S, Collins A (2006) Adherence of community caretakers of children to pre-packaged antimalarial medicines (HOMAPAK) among internally displaced people in Gulu district, Uganda. Malar J 5: 40–49
President's Malaria Initiative Uganda. Operational Plan (MOP) FY 2007; www.fightingmalaria.gov/countries/uganda_mop-fy07.pdf. Last assessed: 2008-02-12
Lemeshow S, Robinson D (1985) Surveys to measure programme coverage and impact: a review of the methodology used by the expanded programme on immunization. World Health Stat Quart 38: 65–75
World Health Organisation (2005) Malaria Indicator Survey: Basic Documentation for Survey Design and Implementation. Geneva
Hackett LW (1944) Spleen measurement in malaria. Journal of the National Malaria Society: 121–123
World Health Organisation (2006) WHO Child Growth Standards. Methods and development. Geneva
World Health Organisation (2000) Obesity: Preventing and managing the global epidemic. Technical Report Series 894. Geneva
Nathan DG, Oski FA (1993) Hematology of infancy and childhood, 4th edn. Philadelphia
Litchfield JT jr, Wilcoxon F (1949) A simplified method of evaluating dose-effect experiments. J Pharm Exp Ther 96: 99–113
Wernsdorfer WH, Wernsdorfer MG (1995) The evaluation of in vitro tests for the assessment of drug response in Plasmodium falciparum. Mitteil Oesterr Gesellsch Tropenmed Parasitol 17: 221–228
Wernsdorfer WH, Landgraf B, Kilimali VA, Wernsdorfer G (1998) Activity of benflumetol and its enantiomers in fresh isolates of Plasmodium falciparum from East Africa. Acta Tropica 70: 9–15
Wernsdorfer WH, Congpuong K, Sirichaisinthop J, Wernsdorfer G (2007) Drug sensitivity of Plasmodium falciparum and vivax in the area of Mae Sot, Tak Province, northwestern Thailand. Trop Med Health 35: 1–9
Zatloukal C, Woitsch B, Noedl H, Prajakwong S, Wernsdorfer G, Wernsdorfer WH (1998) Longitudinale Beobachtungen über die Artemisininempfindlichkeit von Plasmodium falciparum in Thailand. Mitteil Oesterr Gesellsch Tropenmed Parasitol 20: 165–170
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Prugger, C., Engl, M., Ogwang, M. et al. Malariological baseline survey and in vitro antimalarial drug resistance in Gulu district, Northern Uganda. Wien Klin Wochenschr 120 (Suppl 4), 63–68 (2008). https://doi.org/10.1007/s00508-008-1037-y
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DOI: https://doi.org/10.1007/s00508-008-1037-y