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Surgical aspects of gastrinoma in multiple endocrine neoplasia type 1

Chirurgische Aspekte des Gastrinoms bei der Multiplen endokrinen Neoplasie Typ 1

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Zusammenfassung

Das Gastrinom ist der häufigste funktionell aktive pankrearticoduodenale Tumor bei Patienten mit einer Multiplen endokrinen Neoplasie Typ 1 und eine der Haupttodesursachen dieses Syndroms. Ob eine routinemäßige chirurgische Exploration bei Patienten mit nachgewiesenem MEN1-assoziierten Zollinger-Ellison-Syndrom (ZES) durchgeführt werden sollte, wird kontrovers gesehen. Da evidenz-basierte Daten feheln, besteht derzeit auch Uneinigkeit über die durchzuführende operative Prozedur. Dieser Artikel diskutiert die verfügbaren Daten zu möglichen Therapiestrategien beim MEN1-assozierten ZES.

Summary

Gastrinoma is the most frequent functional pancreatioduodenal endocrine tumor in patients with multilpe endocrine neoplasia type 1 (MEN1) and one major determinant of mortality in this syndrome. Whether routine surgical exploration should be performed in a patient with MEN1 associated Zollinger-Ellison syndrome (ZES) to possibly reduce the malignant spread and eventually increase survival still remains controversial. There is not only disagreement about the indication for surgical exploration, but also what type of procedure should be performed, since sufficient evidence-based data are not available. The article discusses the available data on treatment strategies of MEN1 associated ZES.

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Authors and Affiliations

  1. Klinik für Allgemein- und Viszeralchirurgie der Städt. Kliniken Bielefeld-Mitte, Bielefeld, Germany

    Detlef K. Bartsch

  2. Klinik für Visceral-, Thorax- und Gefäßchirurgie der Universität Marburg-Gießen, Marburg, Germany

    Peter Langer & Matthias Rothmund

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  1. Detlef K. Bartsch
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  2. Peter Langer
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  3. Matthias Rothmund
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Correspondence to Detlef K. Bartsch.

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Bartsch, D., Langer, P. & Rothmund, M. Surgical aspects of gastrinoma in multiple endocrine neoplasia type 1. Wien Klin Wochenschr 119, 602–608 (2007). https://doi.org/10.1007/s00508-007-0883-3

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