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What we have learned about Lyme borreliosis from studies in children

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Summary

Although pediatric Lyme borreliosis (LB) need not be a separate nosological entity, there are clinically important differences in presentation, antibiotic regimens and outcomes in children, which provide lessons that can be extrapolated to the disease as it affects adults. A large proportion of the worldwide data is obtained from children. The aim of this presentation is not to present an exhaustive review of the pediatric literature, but to review a selection of pediatric studies that have made a significant contribution to our body of knowledge in Lyme borreliosis.

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References

  • Gerber MA, Shapiro ED, Burke GS, Parcells VJ, Bell GL (1996) Lyme disease in children in southeastern Connecticut. Pediatric Lyme Disease Study Group. N Engl J Med 335 (17): 1270–1274

    Article  CAS  PubMed  Google Scholar 

  • Berglund J, Eitrem R, Ornstein K, Lindberg A, Ringer A, Elmrud H, Carlsson M, Runehagen A, Svanborg C, Norrby R (1995) An epidemiologic study of Lyme disease in southern Sweden. N Engl J Med 333 (20): 1319–1327

    Article  CAS  PubMed  Google Scholar 

  • Duszczyk E, Karney A, Kowalewska-Kantecka B, Gryglicka H (2003) Borreliosis in children – clinical manifestation, diagnosis and treatment. Med Wieku Rozwoj 7 (1): 49–56

    PubMed  Google Scholar 

  • Christova I, Komitova R (2004) Clinical and epidemiological features of Lyme borreliosis in Bulgaria. Wien Klin Wochenschr 116 (1–2): 42–46

    Article  PubMed  Google Scholar 

  • Nadelman RB, Pavia CS, Magnarelli LA, Wormser GP (1990) Isolation of Borrelia burgdorferi from the blood of seven patients with Lyme disease. Am J Med 88 (1): 21–26

    Article  CAS  PubMed  Google Scholar 

  • Feder HM Jr, Gerber MA, Krause PJ, Ryan R, Shapiro ED (1993) Early Lyme disease: a flu-like illness without erythema migrans. Pediatrics 91 (2): 456–459

    PubMed  Google Scholar 

  • Arnez M, Pleterski-Rigler D, Luznik-Bufon T, Ruzic-Sabljic E, Strle F (2003) Solitary and multiple erythema migrans in children: comparison of demographic, clinical and laboratory findings. Infection 31 (6): 404–409

    CAS  PubMed  Google Scholar 

  • Arnez M, Pleterski-Rigler D, Luznik-Bufon T, Ruzic-Sabljic E, Strle F (2002) Children with multiple erythema migrans: are there any pre-treatment symptoms and/or signs suggestive for central nervous system involvement? Wien Klin Wochenschr 114 (13–14): 524–529

    PubMed  Google Scholar 

  • Steere AC, Malawista SE, Snydman DR, Shope RE, Andiman WA, Ross MR, Steele FM (1977) Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three Connecticut communities. Arthritis Rheum 20 (1): 7–17

    CAS  PubMed  Google Scholar 

  • Sood SK, Rubin LG, Blader ME, Ilowite NT (1993) Positive serology for Lyme borreliosis in patients with juvenile rheumatoid arthritis in a Lyme borreliosis endemic area: analysis by immunoblot. J Rheumatol 20 (4): 739–741

    CAS  PubMed  Google Scholar 

  • Huppertz HI, Bentas W, Haubitz I, Girschick HJ, Ganser G, Thon A, Suschke HJ, Schauer-Petrowskaja C, Minden K, Schuchmann L (1998) Diagnosis of paediatric Lyme arthritis using a clinical score. Eur J Pediatr 157 (4): 304–308

    Article  CAS  PubMed  Google Scholar 

  • Ecklund K, Vargas S, Zurakowski D, Sundel RP (2005) MRI features of Lyme arthritis in children. Am J Roentgenol 184 (6): 1904–1909

    Google Scholar 

  • Belman AL, Iyer M, Coyle PK, Dattwyler R (1993) Neurologic manifestations in children with North American Lyme disease. Neurology 43 (12): 2609–2614

    CAS  PubMed  Google Scholar 

  • Christen HJ (1996) Lyme neuroborreliosis in children. Ann Med 28 (3): 235–240

    CAS  PubMed  Google Scholar 

  • Eppes SC, Nelson DK, Lewis LL, Klein JD (1999) Characterization of Lyme meningitis and comparison with viral meningitis in children. Pediatrics 103 (5 Pt 1): 957–960

    Article  CAS  PubMed  Google Scholar 

  • Shah SS, Zaoutis TE, Turnquist J, Hodinka RL, Coffin SE (2005) Early differentiation of Lyme from enteroviral meningitis. Pediatr Infect Dis J 24 (6): 542–545

    Article  PubMed  Google Scholar 

  • Tuerlinckx D, Bodart E, Garrino MG, de Bilderling G (2003) Clinical data and cerebrospinal fluid findings in Lyme meningitis versus aseptic meningitis. Eur J Pediatr 162 (3): 150–153

    PubMed  Google Scholar 

  • Jain VK, Hilton E, Maytal J, Dorante G, Ilowite NT, Sood SK (1996) Immunoglobulin M immunoblot for diagnosis of Borrelia burgdorferi infection in patients with acute facial palsy. J Clin Microbiol 34 (8): 2033–2035

    CAS  PubMed  Google Scholar 

  • Peltomaa M, McHugh G, Steere AC (2004) The VlsE (IR6) peptide ELISA in the serodiagnosis of lyme facial paralysis. Otol Neurotol 25 (5): 838–841

    Article  PubMed  Google Scholar 

  • Berglund J, Stjernberg L, Ornstein K, Tykesson-Joelsson K, Walter H (2002) 5-y Follow-up study of patients with neuroborreliosis. Scand J Infect Dis 34 (6): 421–425

    Article  PubMed  Google Scholar 

  • Rothermel H, Hedges TR 3rd, Steere AC (2001) Optic neuropathy in children with Lyme disease. Pediatrics 108 (2): 477–481

    Article  CAS  PubMed  Google Scholar 

  • Moses JM, Riseberg RS, Mansbach JM (2003) Lyme disease presenting with persistent headache. Pediatrics 112 (6 Pt 1): e477–e479

    Article  PubMed  Google Scholar 

  • Dayan NE, Rubin LG, Di John D, Sood SK (2004) Hypoglycorrhachia in Lyme meningitis. Pediatr Infect Dis J 23 (4): 370–371

    PubMed  Google Scholar 

  • Arav-Boger R, Crawford T, Steere AC, Halsey NA (2002) Cerebellar ataxia as the presenting manifestation of Lyme disease. Pediatr Infect Dis J 21 (4): 353–356

    Article  PubMed  Google Scholar 

  • Krbková L, Štroblová H, Mach V, Habanec T, Stanek G, Khanakah G (2005) Atypical brain involvement in neuroborreliosis. Poster 175, 10th ICLB Vienna 2005

  • Schlesinger PA, Duray PH, Burke BA, Steere AC, Stillman MT (1985) Maternal-fetal transmission of the Lyme disease spirochete, Borrelia burgdorferi. Ann Intern Med 103 (1): 67–68

    CAS  PubMed  Google Scholar 

  • Weber K, Bratzke HJ, Neubert U, Wilske B, Duray PH (1988) Borrelia burgdorferi in a newborn despite oral penicillin for Lyme borreliosis during pregnancy. Pediatr Infect Dis J 7 (4): 286–289

    Article  CAS  PubMed  Google Scholar 

  • Strobino BA, Williams CL, Abid S, Chalson R, Spierling P (1993) Lyme disease and pregnancy outcome: a prospective study of two thousand prenatal patients. Am J Obstet Gynecol 169 (2 Pt 1): 367–374

    CAS  PubMed  Google Scholar 

  • Gerber MA, Zalneraitis EL (1994) Childhood neurologic disorders and Lyme disease during pregnancy. Pediatr Neurol 11 (1): 41–43

    Article  CAS  PubMed  Google Scholar 

  • Salazar JC, Gerber MA, Goff CW (1993) Long-term outcome of Lyme disease in children given early treatment. J Pediatr 122 (4): 591–593

    CAS  PubMed  Google Scholar 

  • Bagger-Sjoback D, Remahl S, Ericsson M (2005) Long-term outcome of facial palsy in neuroborreliosis. Otol Neurotol 26 (4): 790–795

    Article  CAS  PubMed  Google Scholar 

  • Peltomaa M, Saxen H, Seppala I, Viljanen M, Pyykko I (1998) Paediatric facial paralysis caused by Lyme borreliosis: a prospective and retrospective analysis. Scand J Infect Dis 30 (3): 269–275

    Article  CAS  PubMed  Google Scholar 

  • Skogman BH, Croner S, Odkvist L (2003) Acute facial palsy in children – a 2-year follow-up study with focus on Lyme neuroborreliosis. Int J Pediatr Otorhinolaryngol 67 (6): 597–602

    Article  PubMed  Google Scholar 

  • Vazquez M, Sparrow SS, Shapiro ED (2003) Long-term neuropsychologic and health outcomes of children with facial nerve palsy attributable to Lyme disease. 112 (2): e93–e97

  • Thorstrand C, Belfrage E, Bennet R, Malmborg P, Eriksson M (2002) Successful treatment of neuroborreliosis with ten day regimens. Pediatr Infect Dis J 21 (12): 1142–1145

    PubMed  Google Scholar 

  • Eppes SC, Childs JA (2002) Comparative study of cefuroxime axetil versus amoxicillin in children with early Lyme disease. Pediatrics 109 (6): 1173–1177

    Article  PubMed  Google Scholar 

  • Arnez M, Pleterski-Rigler D, Luznik-Bufon T, Ruzic-Sabljic E, Strle F (2002) Solitary erythema migrans in children: comparison of treatment with azithromycin and phenoxymethylpenicillin. Wien Klin Wochenschr 114 (13–14): 498–504

    CAS  PubMed  Google Scholar 

  • Szer IS, Taylor E, Steere AC (1991) The long-term course of Lyme arthritis in children. N Engl J Med 325 (3): 159–163

    Article  CAS  PubMed  Google Scholar 

  • Gerber MA, Zalneraitis EL (1994) Childhood neurologic disorders and Lyme disease during pregnancy. Pediatr Neurol 11 (1): 41–43

    Article  CAS  PubMed  Google Scholar 

  • Bentas W, Karch H, Huppertz HI (2000) Lyme arthritis in children and adolescents: outcome 12 months after initiation of antibiotic therapy. J Rheumatol 27 (8): 2025–2030

    CAS  PubMed  Google Scholar 

  • Sood SK, Ilowite NT (2000) Lyme arthritis in children: is chronic arthritis a common complication? J Rheumatol 27 (8): 1836–1838

    CAS  PubMed  Google Scholar 

  • Adams WV, Rose CD, Eppes SC, Klein JD (1999) Longterm cognitive effects of Lyme disease in children. Appl Neuropsychol 6 (1): 39–45

    Article  CAS  PubMed  Google Scholar 

  • Sikand VK, Halsey N, Krause PJ, Sood SK, Geller R, Van Hoecke C, Buscarino C, Parenti D (2001) Pediatric Lyme Vaccine Study Group. Safety and immunogenicity of a recombinant Borrelia burgdorferi outer surface protein A vaccine against Lyme disease in healthy children and adolescents: a randomized controlled trial. Pediatrics 108 (1): 123–128

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Pediatric Infectious Diseases, Schneider Children's Hospital at North Shore, Albert Einstein College of Medicine, Manhasset, NY, USA

    Sunil K. Sood

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  1. Sunil K. Sood
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Correspondence to Sunil K. Sood.

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Sood, S. What we have learned about Lyme borreliosis from studies in children. Wien Klin Wochenschr 118, 638–642 (2006). https://doi.org/10.1007/s00508-006-0689-8

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  • DOI: https://doi.org/10.1007/s00508-006-0689-8

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