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Molecular and epigenetic regulations and functions of the LAFL transcriptional regulators that control seed development

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Abstract

The LAFL (i.e. LEC1, ABI3, FUS3, and LEC2) master transcriptional regulators interact to form different complexes that induce embryo development and maturation, and inhibit seed germination and vegetative growth in Arabidopsis. Orthologous genes involved in similar regulatory processes have been described in various angiosperms including important crop species. Consistent with a prominent role of the LAFL regulators in triggering and maintaining embryonic cell fate, their expression appears finely tuned in different tissues during seed development and tightly repressed in vegetative tissues by a surprisingly high number of genetic and epigenetic factors. Partial functional redundancies and intricate feedback regulations of the LAFL have hampered the elucidation of the underpinning molecular mechanisms. Nevertheless, genetic, genomic, cellular, molecular, and biochemical analyses implemented during the last years have greatly improved our knowledge of the LALF network. Here we summarize and discuss recent progress, together with current issues required to gain a comprehensive insight into the network, including the emerging function of LEC1 and possibly LEC2 as pioneer transcription factors.

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Acknowledgments

We apologize to all our colleagues whose works and original articles could not be cited because of space limitations. The IJPB benefits from the support of the Labex Saclay Plant Sciences–SPS (ANR-10-LABX-0040-SPS). The collaboration between the authors was supported by the CERES project (ANR-10-BLAN-1238). We thank our colleagues D. De Vos, D. Grain, M. Miquel, J. Thévenin, and A. To for their valuable support to the work presented .

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Author notes

  1. M. Devic & T. J. Roscoe

    Present address: Laboratoire d’Océanographie Microbienne, Observatoire Océanologique, Sorbonne Universités, Université Pierre et Marie Curie (Paris 06) & Centre National pour la Recherche Scientifique CNRS UMR 7621, 66650, Banyuls-sur-Mer, France

Authors and Affiliations

  1. IJPB (Institut Jean-Pierre Bourgin), INRA, AgroParisTech, CNRS, Université Paris-Saclay, RD10, 78026, Versailles, France

    L. Lepiniec, C. Boulard, S. Baud & B. Dubreucq

  2. Régulations Epigénétiques et Développement de la Graine, ERL 5300 CNRS-IRD UMR DIADE, IRD centre de Montpellier, 911 Avenue Agropolis, BP 64501, 34394, Montpellier, France

    M. Devic & T. J. Roscoe

  3. Institut de Biologie de l’ENS, CNRS UMR8197, Ecole Normale Supérieure, 46 rue d’Ulm, 75230, Paris Cedex 05, France

    D. Bouyer

  4. Institute of Plant Sciences Paris-Saclay (IPS2), Université Paris Sud 11, Université Paris-Saclay, 91405, Orsay, France

    D.-X. Zhou

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  1. L. Lepiniec
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Correspondence to L. Lepiniec.

Additional information

Communicated by L. Lepiniec, H. North, G. Ingram.

A contribution to the special issue ‘Seed Biology’.

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Lepiniec, L., Devic, M., Roscoe, T.J. et al. Molecular and epigenetic regulations and functions of the LAFL transcriptional regulators that control seed development. Plant Reprod 31, 291–307 (2018). https://doi.org/10.1007/s00497-018-0337-2

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  • DOI: https://doi.org/10.1007/s00497-018-0337-2

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