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The spatial distribution of the normal reference values of the activated partial thromboplastin time based on ArcGIS and GeoDA

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Abstract

We explored the variation and spatial distribution of the activated partial thromboplastin time (APTT) reference values of healthy people at different altitudes in China in order to develop a scientific basis for a unified standard. The APTT reference values of 49,020 healthy males (41–75 years old) and 32,447 healthy females (41–75 years old) were collected from 601 work units and 546 work units in China, respectively. The relationship between the APTT reference values and altitude was tested by correlation analysis. Linear regression analysis and curve analysis were employed to predict the APTT reference values in the whole country. Trend surface analysis, the variation function, kriging interpolation, and Getis-Ord Gi* statistic were utilized to reveal the spatial characteristics of the values. The result showed a significant positive correlation between the APTT reference values and altitude. The APTT values for females were prolonged for a greater amount of time than the males in several same areas in China. The spatial contact forms of the APTT reference values of healthy Chinese were mainly “high-high” and “low-low,” which was in accord with the first law of geography. The APTT reference values still showed spatial autocorrelation and regional variation. The values were higher in the western and northern areas than in the eastern and southern areas of China. The APTT reference values of people aged 41–75 in China showed regional differences. The APTT reference values in one area can be estimated by using the best prediction model or can be obtained by the geographical distribution.

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Funding

This work was supported by the National Natural Science Foundation of China (No. 40671005) and the Central College Fund (PhD) (No. GK201504015).

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Authors and Affiliations

  1. Institute of Healthy Geography, School of Geography and Tourism, Shaanxi Normal University, Xi’an, 710119, China

    Shaofang Yang, Miao Ge & Xiaoping Li

  2. Forest Inventory and Planning Institute in Guizhou, Guiyang, 550003, China

    Chiqin Pan

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  1. Shaofang Yang
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  2. Miao Ge
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  3. Xiaoping Li
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  4. Chiqin Pan
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Correspondence to Shaofang Yang.

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None of the authors have any financial or other potential conflicts of interest for this study.

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This study was approved by Medical Ethics Committee of Second Affiliated Hospital of Xi’an Jiaotong University medical school, and all subjects gave informed written consent (No. 2010-LS-009).

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The work described was original research that has not been published previously.

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We would like to submit our manuscript for publication on International Journal of Health Geographics.

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Yang, S., Ge, M., Li, X. et al. The spatial distribution of the normal reference values of the activated partial thromboplastin time based on ArcGIS and GeoDA. Int J Biometeorol 64, 779–790 (2020). https://doi.org/10.1007/s00484-020-01868-2

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  • DOI: https://doi.org/10.1007/s00484-020-01868-2

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