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Bitte nicht noch mehr verletzen!

Plädoyer gegen eine invasive Schmerztherapie bei Kindern mit komplexem regionalem Schmerzsyndrom (CRPS)

Please don’t hurt me!

A plea against invasive procedures in children and adolescents with complex regional pain syndrome (CRPS)

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Zusammenfassung

Hintergrund

Das komplexe regionale Schmerzsyndrom (CRPS; früher M. Sudeck) wird auch bei Kindern und Jugendlichen diagnostiziert. Die klinische Präsentation ist nicht immer typisch. Potenziell schädliche invasive schmerztherapeutische Maßnahmen kommen bei betroffenen Kindern zu häufig zum Einsatz.

Material und Methoden

Eine retrospektive Analyse stationär behandelter Kinder mit CRPS wurde durchgeführt.

Ergebnisse

In 6 Jahren wurden stationär 37 Kinder und Jugendliche (35 weiblich, mittleres Alter: 14,3 Jahre) multimodal konservativ schmerztherapeutisch behandelt. Bei der Nachuntersuchung von 26 Patienten (70%) zeigte sich eine signifikante Verbesserung der Erkrankung auf den Ebenen Schmerz, Beeinträchtigung und Medikamenteneinnahme. Zuvor hatte jeder Patient im Mittel 4,4 verschiedene Medikamente erhalten (Spanne: 1–10). Dabei waren 29 verschiedene Pharmaka eingesetzt worden. Invasive schmerztherapeutische Maßnahmen hatten 16 Patienten (43%) frustran durchlitten, 13 Kinder mehrfach. Am häufigsten kamen Sympathikusblockaden zum Einsatz, aber auch Operationen und regionalanästhesiologische Verfahren wurden durchgeführt.

Schlussfolgerung

Bei Kindern und Jugendlichen mit CRPS, die auf eine konservative multiprofessionelle Schmerztherapie in der Regel positiv reagieren, werden zu häufig invasive schmerztherapeutische Maßnahmen eingesetzt, ohne dass deren Nutzen belegt ist.

Die englische Volltextversion dieses Beitrags ist in SpringerLink (unter „Supplemental“) verfügbar.

Abstract

Background

Complex regional pain syndrome (CRPS; formerly known as Morbus Sudeck/reflex dystrophy) is diagnosed in children and adolescents, but the clinical presentation is often atypical. Unfortunately, potentially harmful, invasive treatments are used in pediatric patients.

Patients and methods

A retrospective chart study of pediatric chronic pain patients with CRPS was performed.

Results

Over the course of 6 years, 37 (35 girls) children and adolescents took part in a multidisciplinary chronic pain inpatient program. At admission, patients took on average 4.4 (range 1–10) different medications and 29 different pharmaceuticals were used overall. Prior to admission, invasive pain treatments were performed without success in 16 of the children (43%). At least 13 children received two or more invasive treatments. Although sympathetic blocks were most prevalent, operations and regional anesthesia were also used.

Conclusion

Despite a lack of evidence for invasive procedures, these continue to be used in children and adolescents with CRPS, who later respond positively to conventional treatment.

The English full-text version of this article is available at SpringerLink (under “Supplemental”).

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Literatur

  1. Baron R, Schattenschneider J, Binder A et al (2002) Relation between sympathetic vasoconstrictor activity and pain and hyperalgesia in complex regional pain syndromes: a case-control study. Lancet 359:1655–1650

    Article  PubMed  CAS  Google Scholar 

  2. Beck R (2009) Conservative therapy for complex regional pain syndrome type I in a paediatric patient: a case study. J Can Chiropr Assoc 53:95–101

    Google Scholar 

  3. Bialocerkowski AE, Daly A (2012) Is physiotherapy effective for children with complex regional pain syndrome type 1? Clin J Pain 28:81–91

    Article  PubMed  Google Scholar 

  4. Cepeda M, Carr D, Lau J (2005) Local anesthetic sympathetic blockade for complex regional pain syndrome. Cochrane Database Syst Rev:CD004598

    Google Scholar 

  5. Dadure C, Motais F, Ricard C et al (2005) Continuous peripheral nerve blocks at home for treatment of recurrent complex regional pain syndrome I in children. Anesthesiology 102:387–391

    Article  PubMed  Google Scholar 

  6. Dangel T (1998) Chronic pain management in children. Part I: cancer and phantom pain. Paediatr Anaesth 8:5–10

    Article  PubMed  CAS  Google Scholar 

  7. Dobe M, Hechler T, Behlert J et al (2011) Chronisch schmerzkranke, schwer beeinträchtigte Kinder und Jugendliche: Langzeiterfolge einer dreiwöchigen stationären Schmerztherapie. Schmerz 25:411–422

    Article  PubMed  CAS  Google Scholar 

  8. Genc H, Karagoz A, Saracoglu M et al (2005) Complex regional pain syndrome type-I after rubella vaccine. Eur J Pain 9:517–520

    Article  PubMed  Google Scholar 

  9. Guler-Uysal F, Basaran S, Geertzen J et al (2003) A 2 1/2-year-old girl with reflex sympathetic dystrophy syndrome (CRPS type I): case report. Clin Rehabil 17:224–227

    Article  PubMed  CAS  Google Scholar 

  10. Harden R, Bruehl S, Perez R et al (2010) Validation of the proposed diagnostic criteria (the „Budapest Criteria“) for complex regional pain syndrome. Pain 150:268–274

    Article  PubMed  Google Scholar 

  11. Hechler T, Dobe M, Kosfelder J et al (2009) Effectiveness of a three-week multimodal inpatient pain treatment for adolescents suffering from chronic pain: Statistical and clinical significance. Clin J Pain 25:156–166

    Article  PubMed  Google Scholar 

  12. Hübner B, Hechler T, Dobe M et al (2009) Schmerzbezogene Beeinträchtigung bei Jugendlichen mit chronischen Schmerzen – Erste Überprüfung des Pediatric Pain Disability Index (P-PDI). Schmerz 23:20–32

    Article  PubMed  Google Scholar 

  13. Kachko L, Efrat R, Ben Ami S et al (2008) Complex regional pain syndromes in children and adolescents. Pediatr Int 50:523–527

    Article  PubMed  Google Scholar 

  14. Kato J, Gokan D, Ueda K et al (2011) Successful pain management of primary and independent spread sites in a child with CRPS type I using regional nerve blocks. Pain Med 12:174

    Article  PubMed  Google Scholar 

  15. Kesler R, Saulsbury F, Miller L et al (1988) Reflex sympathetic dystrophy in children: treatment with transcutaneous electric nerve stimulation. Pediatrics 82:728–732

    PubMed  CAS  Google Scholar 

  16. Kohr D, Singh P, Tschernatsch M et al (2011) Autoimmunity against the β(2) adrenergic receptor and muscarinic-2 receptor in complex regional pain syndrome. Pain 152:2690–2700

    Article  PubMed  CAS  Google Scholar 

  17. Lee B, Scharff L, Sethna N et al (2002) Physical therapy and cognitive-behavioral treatment for complex regional pain syndromes. J Pediatr 141:135–140

    Google Scholar 

  18. Low A, Ward K, Wines AP (2007) Pediatric complex regional pain syndrome. J Pediatr Orthop 27:567–572

    Google Scholar 

  19. Marinus J, Moseley G, Birklein F et al (2011) Clinical features and pathophysiology of complex regional pain syndrome. Lancet Neurol 10:637–648

    Article  PubMed  Google Scholar 

  20. Meier P, Zurakowski D, Berde C et al (2009) Lumbar sympathetic blockade in children with complex regional pain syndromes: a double blind placebo-controlled crossover trial. Anesthesiology 111:372–380

    Article  PubMed  CAS  Google Scholar 

  21. Merskey H, Bogduk N (1994) Classification of chronic pain, IASP task force on taxonomy. IASP Press, Seattle, S 40–43

  22. Nordmann G, Lauder G, Grier D (2006) Computed tomography guided lumbar sympathetic block for complex regional pain syndrome in a child: a case report and review. Eur J Pain 10:409–412

    Article  PubMed  Google Scholar 

  23. Olsson G, Meyerson B, Linderoth B (2008) Spinal cord stimulation in adolescents with complex regional pain syndrome type I (CRPS-I). Eur J Pain 12:53–59

    Article  PubMed  Google Scholar 

  24. Price DD, Long S, Wilsey B et al (1998) Analysis of peak magnitude and duration of analgesia produced by local anesthetics injected into sympathetic ganglia of complex regional pain syndrome patients. Clin J Pain 14:216–226

    Article  PubMed  CAS  Google Scholar 

  25. Sherry D, Wallace C, Kelley C et al (1999) Short- and long-term outcomes of children with complex regional pain syndrome type I treated with exercise therapy. Clin J Pain 15:218–223

    Article  PubMed  CAS  Google Scholar 

  26. Sherry D, Weisman R (1988) Psychologic aspects of childhood reflex neurovascular dystrophy. Pediatrics 81:572–578

    PubMed  CAS  Google Scholar 

  27. Simm P, Briody J, McQuade M et al (2009) The successful use of pamidronate in an 11-year-old girl with complex regional pain syndrome: response to treatment demonstrated by serial peripheral quantitative computerised tomographic scans. Bone 46:885–888

    Article  PubMed  Google Scholar 

  28. Stanton R, Malcolm J, Wesdock K et al (1993) Reflex sympathetic dystrophy in children: an orthopedic perspective. Orthopedics 16:773

    PubMed  CAS  Google Scholar 

  29. Stanton-Hicks M (2010) Plasticity of complex regional pain syndrome (CRPS) in children. Pain Med 11:1216–1223

    Article  PubMed  Google Scholar 

  30. Tan E, Van De Sandt-Renkema N, Krabbe P et al (2009) Quality of life in adults with childhood-onset of complex regional pain syndrome type I. Injury 40:901–904

    Article  PubMed  Google Scholar 

  31. Tan E, Zijlstra B, Essink M et al (2008) Complex regional pain syndrome type I in children. Acta Paediatr 97:875–879

    Article  PubMed  Google Scholar 

  32. Wilder R (2006) Management of pediatric patients with complex regional pain syndrome. Clin J Pain 22:443–448

    Article  PubMed  Google Scholar 

  33. Wilder R (1996) Reflex sympathetic dystrophy in children and adolescents: differences from adults. In: Jänig W, Stanton-Hicks M (Hrsg) Reflex sympathetic dystrophy: a reappraisal. Progress in pain research and management, Bd. 6. IASP Press, Seattle, S 67–79

  34. Wilder R, Berde C, Wolohan M et al (1992) Reflex sympathetic dystrophy in children. Clinical characteristics and follow-up of seventy patients. J Bone Joint Surg 74:910–919

    Google Scholar 

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Zernikow, B., Dobe, M., Hirschfeld, G. et al. Bitte nicht noch mehr verletzen!. Schmerz 26, 389–395 (2012). https://doi.org/10.1007/s00482-012-1164-2

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