Zusammenfassung
Die epidurale Rückenmarkstimulation (SCS) ist ein reversibles, aber invasives Verfahren, das bei neuropathischen Schmerzen, z. B. beim CRPS I und bei überwiegenden chronischen Radikulopathien im Rahmen eines Failed-back-surgery-Syndroms nach erfolgloser konservativer Therapie eingesetzt werden sollte. SCS kann auch dem Ausschluss von kurativen Verfahren und konservativen Therapieversuchen bei vaskulär bedingten Schmerzen wie z. B. der peripheren arteriellen Verschlusskrankheit Stadium II und III nach Fontaine und der therapierefraktären Angina pectoris erfolgreich zum Einsatz kommen. Die klinische Praxis hat gezeigt, bei welchen Krankheitsbildern die epidurale Rückenmarkstimulation keinen Erfolg hat, z. B. Schmerzen beim kompletten Querschnittsyndrom oder bei Atrophie/Verletzung der sensiblen Bahnen des Rückenmarks oder bei Karzinomschmerzen. Entscheidend ist neben der Diagnosestellung eine geeignete und kritische Patientenselektion. Die epidurale Rückenmarkstimulation sollte immer im Rahmen eines interdisziplinären multimodalen Therapiekonzepts eingesetzt werden. Die Implantation sollte nur in Therapiezentren erfolgen, die Erfahrung mit der Therapie haben und die in der Lage sind, potenzielle Komplikationen zu behandeln.
Abstract
Epidural spinal cord stimulation (SCS) is a reversible but invasive procedure which should be used for neuropathic pain, e.g. complex regional pain syndrome I (CRPS) and for mostly chronic radiculopathy in connection with failed back surgery syndrome following unsuccessful conservative therapy. Epidural SCS can also successfully be used after exclusion of curative procedures and conservative therapy attempts for vascular-linked pain, such as in peripheral arterial occlusive disease stages II and III according to Fontaine and refractory angina pectoris. Clinical practice has shown which clinical symptoms cannot be successfully treated by epidural SCS, e.g. pain in complete paraplegia syndrome or atrophy/injury of the sensory pathways of the spinal cord or cancer pain. A decisive factor is a critical patient selection as well as the diagnosis. Epidural SCS should always be used within an interdisciplinary multimodal therapy concept. Implementation should only be carried out in experienced therapy centers which are in a position to deal with potential complications.
Literatur
Amann W, Berg P, Gersbach PA et al (2003) Study EPOS group: Spinal cord stimulation in the treatment of non-reconstructable stable critical leg ischemia: results of the European Peripheral Vascular Outcome Study. Eur J Vasc Endovasc Surg 26:280–286
Andrell P, Ekre O, Eliasson T et al (2003) Cost-effectiveness of spinal cord stimulation versus coronary artery bypass grafting in patients with severe angina pectoris – long-term results from the ESBY study. Cardiology 99:20–24
Arbeitsgemeinschaft wissenschaftlicher Fachgesellschaften – AWMF (2008) Erarbeitung von Leitlinien für Diagnostik und Therapie. Methodische Empfehlungen. http://www.leitlinien.net
Cook A, Oygar A, Baggenstos P et al (1976) Vascular disease of extremities. Electrical stimulation of spinal cord and posterior roots. N Y State J Med 76:366–368
Cruccu G, Anand P, Attal N et al (2004) EFNS guidelines on neuropathic pain assessment. Eur J Neurol 11:153–162
Cruccu G, Aziz TZ, Garcia-Larrea L et al (2007) EFNS guidelines on neurostimulation therapy for neuropathic pain. Eur J Neurol 14:952–970
DeJongste MJL, Nagelkerke D, Hooyschuur CM et al (1994) Stimulation characteristics complications, and efficacy of spinal cord stimulation systems in patients with refractory angina: a prospective feasibility study. Pacing Clin Electrophysiol 17:1751–1760
Donas KP, Schulte S, Ktenidis K et al (2005) The role of epidural spinal cord stimulation in the treatment of Buerger’s disease. J Vasc Surg 41:830–836
Eddicks S, Maier-Hauff K, Schenk M et al (2007) Thoracic spinal cord stimulation improves functional status and relieves symptoms in patients with refractory angina pectoris: the first placebo-controlled randomized study. Heart 93:585–590
Ekre O, Eliasson T, Norrsell H et al (2002) Long-term effects of spinal cord stimulation and coronary artery bypass grafting on quality of life and survival in the ESBY study. Eur Heart J 23:1938–1945
Harke H, Rosenow E, Tronnier V et al (2003) Standardisierung neuromodulativer Verfahren. Schmerz 17:44–49
Hautvast RW, DeJongste MJ, Staal MJ et al (1998) Spinal cord stimulation stimulation in chronic intractable angina pectoris: a randomized controlled efficacy study. Am Heart J 136:1114–1120
Javid MJ, Hader EJ (1998) Long-term follow-up review of patients who underwent laminectomy for lumbar stenosis: a prospective study. J Neurosurg 89:1–7
Kemler MA, Barends GA, Kleef M van et al (2000) Spinal cord stimulation in patients with chronic reflex sympathetic dystrophy. N Engl J Med 343:618–643
Kemler MA, Furnée CA (2002) Economic evaluation of spinal cord stimulation for chronic sympathetic reflex dystrophy. Neurology 259:1203–1209
Kemler MA, Vet HC de, Barendse GA et al (2004) The effect of spinal cord stimulation in patients with chronic sympathetic reflex dystrophy: two years‘ follow-up of the randomized controlled trial. Ann Neurol 55:13–18
Kemler MA, Vet HC de, Barendse GA et al (2006) Spinal cord stimulation for chronic sympathetic dystrophy – five year follow-up. N Engl J Med 354:2394–2396
Kemler MA, Vet HC de, Barends GA et al (2008) Effect of spinal cord stimulation for chronic complex regional pain syndrome Type I: five-year final follow-up of patients in randomized controlled trial. J Neurosurg 108:292–298
Klomp HM, Spincemaille GH, Steyerberg EW et al (1999) Spinal-cord stimulation in critical limb ischemia: a randomized trial: ESES study group. Lancet 353:1040–1044
Kumar K, Malik S, Demeria D (2002) Treatment of chronic pain with spinal cord stimulation versus alternative therapies: cost effectiveness analysis. Neurosurgery 51:106–116
Kumar K, Taylor RS, Jacques L et al (2007) Spinal cord stimulation versus conventional medical management for neuropathic pain: A multicentre randomised controlled trial in patients with failed back surgery syndrome. Pain 132:179–188
Kumar K, Taylor RS, Jacques L et al (2008) The effects of spinal cord stimulation in neuropathic pain are sustained: a 24-month follow-up of the prospective randomized controlled multicenter trial of the effectiveness of spinal cord stimulation. Neurosurgery 63:762–770
Mannheimer C, Carlsson CA, Ericsson K et al (1982) Transcutaneous electrical nerve stimulation in severe angina pectoris. Eur Heart J 3:297–302
Mannheimer C, Eliasson T, Augustinsson LE et al (1998) Electrical stimulation versus coronary artery bypass surgery in severe angina pectoris: the ESBY study. Circulation 97:1157–1163
Mannheimer C, Camici P, Chester MR et al (2002) The problems of chronic refractory angina: Report from the ESC Joint Study Group on the treatment of refractory angina. Eur Heart J 23:355–370
Melzack R, Wall P (1965) Pain mechanisms. A new theory. Science 150:971–979
Nationale Versorgungsleitlinien – Methodenreport (2008) http://versorgungsleitlinien.de/methodik/pdf/nvl_methodik_4.aufl.pdf
NICE Technology appraisal guidance 159 (2008) Spinal cord stimulation for chronic pain of neuropathic and ischaemic origin. http://www.nice.org.uk
Nickel FT, Maihöfner C (2010) Aktuelle Erkenntnisse zur Pathophysiologie des CRPS I. Handchir Mikrochir Plast Chir 42:8–14
North RB, Kidd DH, Farrokhi F et al (2005) Spinal cord stimulation versus repeated lumbosacral spine surgery for chronic pain: a randomized controlled trial. Neurosurgery 56:98–106
North RB, Kidd D, Shipley J et al (2007) Spinal cord stimulation versus reoperation for failed back surgery syndrome: a cost effectiveness and cost utility analysis based on a randomized, controlled trial. Neurosurgery 61:361–368
North R, Shipley J (2007) Practice parameters fort he use of spinal cord stimulation in the treatment of chronic neuropathic pain. Pain Med 8(Suppl s4):S200–S275
Olsson GL, Meyerson BA, Linderoth B (2008) Spinal cord stimulation in adolescents with complex regional pain syndrome I. Eur J Pain 12:53–59
Pace AV, Saratzis N, Karokis D et al (2002) Spinal cord stimulation in Buerger’s disease. Ann Rheum Dis 61:1114
Pedrini L, Magnoni F (2007) Spinal cord stimulation for lower limb ischemic pain treatment. Interact Cardiovasc Thorac Surg 6:495–500
Rasmussen MB, Hole P, Andersen C (2004) Electric spinal cord stimulation (SCS) in the treatment of angina pectoris: a cost-utility analysis. Neuromodulation 7:89–96
Schiltenwolf M, Eich W, Schmale-Grete R et al (2008) Ziele der Leitlinie zur Diagnostik und Therapie des Fibromyalgiesyndroms. Schmerz 22:241–243
Sgueglia GA, Sestito A, Spinelli A et al (2007) Long-term follow-up of patients with syndrome X treated by spinal cord stimulation. Heart 93:591–597
Stanton-Hicks M (2006) Complex regional pain syndrome: Manifestations and the role of neurostimulation. J Pain Symptom Manage 31:S20–S24
Stanton-Hicks MD, Burton AW, Bruehl SP et al (2002) An updated interdisciplinary clinical pathway for CRPS: report of an expert panel. Pain Practice 2:1–16
Taylor RJ, Taylor RS (2005) Spinal cord stimulation for failed back surgery syndrome: a decision analytic model and cost-effectiveness analysis. Int J Technol Assess Health 21:351–358
Taylor RS (2006) Spinal cord stimulation in complex regional pain syndrome and refractory neuropathic back and leg pain/failed back surgery syndrome: results of a systematic review and meta-analysis. J Pain Symptom Manage 31:S13–S19
Turner JA, Loeser JD, Bell KG (1995) Spinal cord stimulation for chronic low back pain: a sytematic literature review synthesis. Neurosurgery 37:1088–1096
Ubbink DT, Vermeulen H, Spincemaille GH et al (2004) Systematic review and meta-analysis of controlled trials concerning spinal cord stimulation for inoperable critical leg ischemia. Br J Surg 91:948–955
Ubbink DT, Vermeulen H (2005) Spinal cord stimulation for non-recontructable chronic critical leg ischemia. Cochrane Database Syst Rev (3)
Ubbink DT, Vermeulen H (2006) Spinal cord stimulation for critical leg ischemia: a review of effectiveness and optimal patient selection. J Pain Sympt Manage 31:S30–S35
Wall PD, Sweet WH (1967) Pain abolition in man. Science 155:108–109
Yu W, Maru F, Edner F et al (2004) Spinal cord stimulation for refractory angina pectoris: a retrospective analysis of efficacy and cost-benefit. Coron Art Dis 15:31–37
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Ein Erratum zu diesem Beitrag ist unter http://dx.doi.org/10.1007/s00482-011-1128-y zu finden.
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Tronnier, V., Baron, R., Birklein, F. et al. Epidurale Rückenmarkstimulation zur Therapie chronischer Schmerzen. Schmerz 25, 484–492 (2011). https://doi.org/10.1007/s00482-011-1094-4
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DOI: https://doi.org/10.1007/s00482-011-1094-4
Schlüssenwörter
- Epidurale Rückenmarkstimulation (SCS)
- Chronischer Schmerz
- Komplexes regionales Schmerzsyndrom (CRPS)
- Angina pectoris
- Leitlinie