Skip to main content
Log in

Neuromodulation der Spastik bei Kindern durch intrathekal verabreichtes Baclofen

Neuromodulation of spasticity in children by intrathecal baclofen

  • Übersichten
  • Published:
Der Schmerz Aims and scope Submit manuscript

Zusammenfassung

Hintergrund

Die intrathekale Behandlung mit Baclofen (ITB) ist ein Bestandteil der komplexen Therapie von Patienten mit zerebraler Spastik mit dem Ziel, die Motorik zu verbessern und die Schmerzintensität zu mindern.

Material und Methodik

Die ITB wird seit 1999 im Orthopädischen Spital Speising durchgeführt. Von 1999–2006 wurden 15 Kinder im Alter zwischen 3 und 16 Jahren ausgewählt.

Ergebnisse

Das durchschnittliche Ausmaß der Spastik nach Ashworth (Skala 1–5) sank nach der ITB von 4,38 auf 3,0. Die im Sitzen verbrachte Zeit verlängerte sich von 3,3 auf 5,8 h/Tag, die Schmerzintensität (Visuelle Analogskala, VAS 1–10) sank von 4,2 auf 0,6. Der Pflegeaufwand verringerte sich von 7,5 auf 3,4 (VAS 1–10). Ebenfalls verbesserte sich bei den Kindern die Stimmungslage, des Weiteren bei 8 Kindern die Schluckfähigkeit, die Kopfhaltung und die Konzentrationsfähigkeit.

Schlussfolgerung

Die ITB ermöglicht eine Neuromodulation auch bei den Patienten im Kindesalter, bei denen die Spastik Bestandteil einer komplexen neuromotorischen Symptomatik ist.

Abstract

Introduction

Treatment with intrathecal baclofen (ITB) is an important part of the complex therapy of patients with cerebral spasticity aiming to improve the motoric functions and to reduce pain intensity.

Material and methods

ITB was started in the Orthopaedic Hospital in Speising in 1999. From 1999 to 2006 a total of 15 children aged 3 to 16 years old were selected for this special treatment.

Results

The average degree of spasticity according to Ashworth (scale 1–5) could be reduced by ITB from 4.38 to 3.0, the time spent sitting could be increased from 3.3 to 5.8h per day and the pain intensity (VAS 1–10) could be reduced from 4.2 to 0.6. The time necessary for nursing treatment was shortened from 7.5 to 3.4 (VAS 1–10). Also improved was the emotional situation, the ability to swallow, the posture of the head and the concentration ability.

Conclusion

ITB provides neuromodulation even in pediatric patients with complex neuromotoric spasticity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2
Abb. 3
Abb. 4
Abb. 5
Abb. 6
Abb. 7
Abb. 8
Abb. 9

Literatur

  1. Albright AL, Shultz B (1999) Plasma baclofen levels in children receiving continuous intrathecal baclofen infusion. J Child Neurol 14:408–409

    Article  CAS  PubMed  Google Scholar 

  2. Albright AL, Gilmartin R, Swift DA (2003) Long-term intrathecal baclofen therapy for severe spasticity of cerebral origin. J Neurosurg 98(2):291–295

    Article  CAS  PubMed  Google Scholar 

  3. Albright AL (2006) Review of US experience and evidence. Scientific Forum for the Management of Paediatric Spasticity, Oslo

  4. Albright AL, Susan S (2006) Intrathecal baclofen therapy in children. Neurosurg Focus 21:2

    Article  Google Scholar 

  5. Brunstrom JE (2001) Clinical considerations in cerebral palsy and spasticity. J Child Neurol 16(1):10–15

    Article  CAS  PubMed  Google Scholar 

  6. Coffey RJ, Edgar TS, Francisco GE et al (2002) Abrupt withdrawal from intrathecal baclofen: recognition and management of potentially life-threatening syndrome. Arch Phys Med Rehabil 83(6):735–741

    Article  PubMed  Google Scholar 

  7. Crouchman M (2000) Principles of management of cerebral palsy. Curr Paediatr 10:167–171

    Article  Google Scholar 

  8. Grabb PA, Guin-Renfroe S, Meythaler JM (1999) Midthoracic catheter tip placement for intrathecal baclofen administration in children with quadriparetic spasticity. Neurosurgery 45(4):833–837

    Article  CAS  PubMed  Google Scholar 

  9. Hoving MA, van Raak EP, Spincemaille GH et al (2007) Dutch Study Group on Child Spasticity. Intrathecal baclofen therapy in children with spastic cerebral palsy: a double-blind, randomized, placebo-controlled, dose finding study. Dev Med Child Neurol 49(9):654–659

    Article  PubMed  Google Scholar 

  10. Hoving MA, Evers SM, Ament AJ et al (2008) Dutch Study Group on Child Spasticity: Intrathecal baclofen therapy in children with intractable spastic cerebral palsy: a cost-effectiveness analysis. Dev Med Child Neurol 50(6):450–455

    Article  CAS  PubMed  Google Scholar 

  11. Kluger G, Lütjen S, Granel M (2003) Die intrathekale Baclofentherapie bei Kindern mit schwerer Spastik und/oder Dystonie: 15 Jahre Erfahrung bei 68 Patienten. Neuropaed Klinik Praxis 1:18–24

    Google Scholar 

  12. Koch von CS, Park TS, Steinbok P et al (2001) Selective posterior rhizotomy and intrathecal baclofen for the treatment of spasticity. Pediatr Neurosurg 35:57–65

    Article  Google Scholar 

  13. Kolodziej M, Riegel T, Celic I (2005) Is there a higher rate of infection after pump implantation in patients with MRSA? Congress abstracts 7th INS World Congress, June 10–17th 2005, Rome, Italy

  14. Koman LA, Smith BP (2005) The role of intrathecal baclofen. In: Koman LA, Smith BP (eds) Management of spasticity in cerebral palsy. Data Trace Publishing Company Towson, Maryland, p 159

  15. Krach LE, Kriel RL, Gilmartin RC (2004) Hip status in cerebral palsy after one year of continuous intrathecal baclofen infusion. Pediatr Neurol 30(3):163–168

    Article  PubMed  Google Scholar 

  16. Kroin JS, Penn RD (1991) Cerebrospinal fluid pharmacokinetics of lumbar intrathecal baclofen. In: Lakke JPWF, Delhaas EM, Rutgers AWF (eds) Parenteral drug therapy in spasticity and Parkinson’s disease. Parthenon Publishing, Canforth, pp 73–83

  17. Lance JW (1980) Symposium synopsis. In: Feldman RG, Young RR, Koella WP (eds) Spasticity: disorder motor control. Year Book Medical, Chicago, pp 485–494

  18. Lütjen S (2004) Intrathekale Baclofentherapie bei zerebraler Hypoxie, User Group Meeting 11.–13.9.2004, Schloss Bellermont

  19. Motta F (2006) Intrathecale baclofen therapy and orthopaedic surgery. Scientific Forum for the M>anagement of Paediatric Spasticity, Oslo, 20.–22.1.2006

  20. Müller H, Zierski J, Dralle D et al (1998) Pharmacokinetics of intrathecal baclofen. In: Müller H, Zierski J, Penn RD (eds) Local-spinal therapy of spasticity. Springer, New York, pp 223–226

  21. Nielsen JB, Petersen NT, Crone C et al (2005) Stretch reflex regulation in healthy subjects and patients with spasticity. Neuromodulation 8(1):49–57

    Article  Google Scholar 

  22. Rawlins PK (2004) Intrathecal baclofen therapy over 10 years, J Neurosci Nurs 36(6):322–327

    Google Scholar 

  23. Roeste GK (2006) Outcomes of ITB in paediatric population. Scientific Forum for the Management of Paediatric Spasticitiy, Oslo, 20.–22.1.2006

  24. Saltuari L (2002) Intrathecale Baclofentherapie. Indikationen. Vortrag, User Group Meeting Neuromodulation, Millenium Tower, Wien, 9.3.2002

  25. Tichý M, Kraus K, Hořínek D, Vaculík M (2004) Selective rhizotomy in the treatment of severe spasticity in cerebral palsy. Bolest 7(1):23–26

    Google Scholar 

  26. Zorowith RD, Leffler JB, Murray CF, Robinson R (2008) Spasticity: a clinical review. http://cme.medscape.com/viewarticle/576698

  27. Cumlivski R, Redl G, Strobl W et al (2006) Pharmacological neuromodulation of the spasticity by using of intrathecal applied baclofen in the children. Bolest 2:88–98

    Google Scholar 

Download references

Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to R. Cumlivski.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cumlivski, R., Redl, G., Strobl, W. et al. Neuromodulation der Spastik bei Kindern durch intrathekal verabreichtes Baclofen. Schmerz 23, 592–599 (2009). https://doi.org/10.1007/s00482-009-0841-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00482-009-0841-2

Schlüsselwörter

Keywords

Navigation