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Cancer risk analysis and assessment of trihalomethanes in drinking water

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Abstract

This study conducts risk assessment for an array of health effects that may result from exposure to disinfection by-products (DBPs). An analysis of the relationship between exposure and health-related outcomes is conducted. The trihalomethanes (THMs) species have been verified as the principal DBPs in the drinking water disinfection process. The data used in this study was collected from the Taiwan Water Corporation (TWC) from 1998 to 2002. Statistical analysis, multistage of Benchmark model, Monte Carlo simulation (MCS) and sensitive analysis were used to estimate the cancer risk analysis and assessment. This study included the statistical data analysis, epidemiology investigation and cancer risk assessment of THMs species in drinking water in Taiwan. It is more significant to establish an assessment procedure for the decision making in policy of drinking water safety predominantly.

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References

  • Bellar TA, Lichtenberg JJ, Kroner RC (1974) The occurrence of organohalides in chlorinated drinking waters. J Am Water Works Assoc 66:703–706

    CAS  Google Scholar 

  • Bove FJ, Fulcomer MC, Klotz JB, Esmart J, Dufficy EM, Savrin JE (1995) Public drinking water contamination birth outcome. Am J Epidemiol 141:850–862

    PubMed  CAS  Google Scholar 

  • Cantor KP, Hoover R, Mason TJ, McCabe LJ (1978) Association of cancer mortality with halomethanes in drinking water. J Natl Cancer Inst 61:979–985

    PubMed  CAS  Google Scholar 

  • Cantor KP, Hoover R, Hartge P (1987) Bladder cancer, drinking water sources, and tap water consumption: a case control study. J Natl Cancer Inst 79:1269–1279

    PubMed  CAS  Google Scholar 

  • Cantor KP, Lynch CF, Hildesheim ME, Dosemeci M, Lubin J, Alavanja M, Craun G (1998) Drinking water source and chlorination byproducts I Risk of bladder cancer. Epidemiology 9:21–28

    Article  PubMed  CAS  Google Scholar 

  • Chen WM (2003) Health risk analysis and assessment of trihalomethanes in drinking water of Taiwan, Master Thesis, Feng Chia University

  • Dan YJ (2003) Formation and risk assessment of trihalomethanes in drinking water, Master Thesis, National Taiwan University

  • Doyle TJ, Zheng W, Cerhan JR, Hong CP, Sellers TA, Kushi LH, Polsom AR (1997) The association of drinking water source and chlorination by-products with cancer incidence among postmenopausal women in Iowa: a prospective cohort study. Am J Public Health 87:1168–1176

    PubMed  CAS  Google Scholar 

  • Garcia-Villanova RJ, Garcia C, Gomez JA, Garcia MP, Ardanny R (1997) Formation, evolution and modeling of trihalomethanes in the drinking water of a town: at the muncipal treatment utilities. Water Res 31:1299–1308

    Article  Google Scholar 

  • Gallagher MD, Nuckols JR, Stallones L, Savitz DA (1998) Exposure to trihalomethanes and adverse pregnancy outcomes. Epidemiology 9:484–489

    Article  PubMed  CAS  Google Scholar 

  • Golfinopoulos SK, Kostopoulou MN, Lekkas TD (1996) THMs formation in the high bromide water supply of Athens. J Environ Sci Health A 31:67–81

    Google Scholar 

  • Heywood R, Sortwell RJ, Noel PRB (1979) Safety evaluation of toothpaste containing chloroform: III. Long-term study in beagle dogs. J Environ Pathol Toxicol 2:835–851

    PubMed  CAS  Google Scholar 

  • Hossein P, Stevens AA (1995) Relationship between trihalomethanes and haloacetic acids with total organic halogen during chlorination 29:2059–2062

    Google Scholar 

  • Houston AC (1913) Studies in water supply. Macmillan & Co, London

    Google Scholar 

  • Hsu CH, Jeng WL, Chang RM, Chien LC, Han BC (2001) Estimation of potential lifetime cancer risk for trihalomethanes from consuming chlorinated drink water in Taiwan. Environ Res 85:77–82

    Article  PubMed  CAS  Google Scholar 

  • Jo WK, Weisel CP, Lioy PJ (1990) Routes of chloroform exposures and body burden from showering with chlorinated tap water. Risk Anal 10:575–580

    Article  PubMed  CAS  Google Scholar 

  • Kramer MD, Lynch CF, Isacson P, Hanson JW (1992) The association of waterborne chloroform with intrauterine growth retardation. Epidemiology 3:407–413

    PubMed  CAS  Google Scholar 

  • Lee SC, Guo H, Lam SMJ, Lau SLA (2004) Multipathway risk assessment on disinfection by-products of drinking water in Hong Kong. 94:47–56

  • Lin TF, Hoang SW (2000) Inhalation exposure to THMs from drinking water in south Taiwan. Sci Total Environ 246:41–49

    Article  PubMed  CAS  Google Scholar 

  • Little, John C (1992) Applying the two-resistance theory to contaminant volatilization in showers. Environ Sci Technol 26:1341–1349

    Article  CAS  Google Scholar 

  • Maxwell NI, Burmaster DE, Ozonoff D (1991) Trihalomethanes andmaximum contaminant levels: the significance of inhalation and dermal exposures to chloroform in household water. Regul Toxicol Pharmacol 14:297–312

    Article  PubMed  CAS  Google Scholar 

  • MCKone TE (1989) Household exposure models. Toxicol Lett 49:321–339

    Article  PubMed  CAS  Google Scholar 

  • Morris RD, Audet AM, Angelillo IF, Chalmers TC, Mosteller F (1992) Chlorination, chlorination by-products, and cancer: a meta-analysis. Am J Public Health 82:955–963

    Article  PubMed  CAS  Google Scholar 

  • National Research Council (1983) Risk assessment in the federal government: managing the process. NAS Press, Washington

    Google Scholar 

  • National Toxicology Program (NTP) (1985) Toxicology and carcinogenesis studies of chlorodibromomethane (CAS. No. 124–48–1) in F344/N rats and B6C3F1 mice (gavage studies). National Toxicology Program Technical Report Series No. 282. DHHS Publications No. (NIH), 85–2538

  • National Toxicology Program (NTP) (1987) Toxicology and carcinogenesis studies of bromodichloromethane (CAS. No. 75–27–4) in F344/N rats and B6C3F1 mice (gavage studies). National Toxicology Program Technical Report Series No. 321. DHHS Publications No. (NIH), 85–2537

  • National Toxicology Program (NTP) (1988) Toxicology and carcinogenesis studies of bromoform (CAS. No. 75–25–2) in F344/N

  • Page T, Harris RH, Epstein SS (1976) Drinking water and cancer mortality in Louisiana. Science 193:55–57

    PubMed  CAS  Google Scholar 

  • Rook JJ (1974) Formation of haloforms during chlorination of natural water. Water Treat Exam 23:234–243

    Google Scholar 

  • U.S. Environmental Protection Agency (USEPA) (2004) The Benchmark Dose Software 1.3.2. Available on the Internet at: http://www.epa.gov/ncea

  • U.S. Environmental Protection Agency (USEPA) (1989) Risk assessment guidance for superfund. USEPA, Washington DC

    Google Scholar 

  • U.S. Environmental Protection Agency (USEPA) (1997) Exposure factors handbook. USEPA, Washington DC

    Google Scholar 

  • USEPA (1986) Guidelines for carcinogen risk assessment. U.S. Environmental Protection Agency, Washington DC. EPA/600/8–87/045

  • USEPA (1999) Guidelines for carcinogen risk assessment. Risk Assessment Forum, U.S. Environmental Protection Agency, Washington DC. NCEA-F-0644

  • USEPA (2002) Integrated risk information system (electronic data base). U.S. Environmental Protection Agency, Washington DC. Available on Internet at: http://www.epa.gov/iris

  • USEPA (2003a) Risk assessment information system (electronic data base). U.S. Environmental Protection Agency, Washington DC. Available on Internet at: http://www.cfpub.epa.gov/iris Cited Aug 2003

  • USEPA (2003b) The Benchmark Dose Software 1.3.2. EPA NCEA. Available on Internet at:http://www.epa.gov/ncea

  • Waller K, Swan SH, DeLorenze G, Hopkins B (1998) Trihalomethanes in drinking water and spontaneous abortion. Epidemiology 9:134–140

    Article  PubMed  CAS  Google Scholar 

  • Wang KS, Dan YJ (2003) Health risk assessment and distribution of trihalomethanes in drinking water of Taiwan. In: Twenty-first conference, Taiwan Water Cooperation

  • Weisel CP, Jo WK (1996) Ingestion, inhalation and dermal exposure to chloroform andtrichlor oethene from tap water. Environ Health Perspect 104:48–51

    PubMed  CAS  Google Scholar 

  • Weisel CP, Kim H, Haltmeier P, Klotz JB (1999) Exposure estimates to disinfection by-products of chlorinated drinking water. Environ Health Perspect 107:103–110

    PubMed  CAS  Google Scholar 

  • Wu KY (1999) Applicated toxicological mechanism in the risk assessment (in Chinese). Taiwan National Science Council report (NSC 89-2621-Z-039-001)

  • Wu KY, Chen MJ, Chang L (2003) A new approach to estimate the volatilization rates of volatile organic compounds during showering. Atmos Environ 37:4325–4333

    Article  CAS  Google Scholar 

  • Yang CY, Chiu JF, Chiu HF, Wang TN, Lee CH, Ko YC (1996) Relationship between water hardness and coronary mortality in Taiwan. J Toxicol Environ Health 49:1–9

    Article  PubMed  CAS  Google Scholar 

  • Yang CY, Chiu HF, Cheng MF, Tsai SS (1998) Chlorination of drinking water and cancer mortality in Taiwan. Environ Res 78:1–6

    Article  PubMed  CAS  Google Scholar 

  • Yang CY, Cheng BH, Tsai SS, Wu TN, Lin MC, Lin KC (2000) Association between chlorination of drinking water and adverse pregnancy outcome in Taiwan. Environ Health Perspect 108:765–768

    PubMed  CAS  Google Scholar 

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Acknowledgements

The authors gratefully acknowledge the fund support by National Science Council (NSC-93-2621-Z-035-002)and the assistance of the Taiwan Water Corporation in this study.

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Authors and Affiliations

  1. Department of Water Source Engineering, 100, Wnehwa Road, Seatwen, Taichung, 407, Taiwan, ROC

    Han-Keng Lee & Wei-Ming Chen

  2. Graduate Institute of Civil and Hydraulic Engineering, 100, Wnehwa Road, Seatwen, Taichung, 407, Taiwan, ROC

    Yir-Yarn Yeh

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  1. Han-Keng Lee
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  2. Yir-Yarn Yeh
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  3. Wei-Ming Chen
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Correspondence to Yir-Yarn Yeh.

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Lee, HK., Yeh, YY. & Chen, WM. Cancer risk analysis and assessment of trihalomethanes in drinking water. Stoch Environ Res Ris Assess 21, 1–13 (2006). https://doi.org/10.1007/s00477-006-0039-4

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