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Hyperparathyroidism during growth hormone treatment: a role for puberty?

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Abstract 

We describe three adolescent patients on chronic hemodialysis with a pubertal growth spurt who developed severe hyperparathyroidism during recombinant human growth hormone treatment. Parathyroid hormone levels were raised in parallel with the increase in linear growth in all patients. In two patients, hyperparathyroidism was successfully controlled with an increase in calcitriol dosage. In the third patient, growth hormone had to be withdrawn. We discuss the possibility that puberty is a risk factor for the development of hyperparathyroidism during growth hormone therapy.

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Authors and Affiliations

  1. Division of Nephrology and Dialysis, ”Bambino Gesù” Children’s Research Hospital, Piazza Sant’ Onofrio 4, I-00165 Rome, Italy e-mail: picca@opbg.net Tel.: +39-06-68592393, Fax: +39-06-68592602, , , , , , IT

    Stefano Picca & Gianfranco Rizzoni

  2. Auxology Service, ”Bambino Gesu’’ Children’s Research Hospital, Rome, Italy, , , , , , IT

    Marco Cappa

Authors
  1. Stefano Picca
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  2. Marco Cappa
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  3. Gianfranco Rizzoni
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Received: 2 September 1998 / Revised: 28 April 1999 / Accepted: 3 May 1999

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Picca, S., Cappa, M. & Rizzoni, G. Hyperparathyroidism during growth hormone treatment: a role for puberty?. Pediatr Nephrol 14, 56–58 (2000). https://doi.org/10.1007/s004670050014

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  • DOI: https://doi.org/10.1007/s004670050014

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