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The importance of ambulatory blood pressure monitoring for diagnosing masked hypertension in patients with renal parenchymal scarring

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Abstract

Background

The most well-known and common long-term complication in children with renal parenchymal scarring (RPS) is hypertension (HT). The present study aimed to evaluate the presence of HT in children with RPS based on ambulatory blood pressure monitoring (ABPM) and to compare the patients’ blood pressure (BP) to that in healthy controls matched for age, gender, and BMI.

Methods

The study included 55 patients aged < 18 years diagnosed with RPS who were followed up for ≥ 1 year and 48 healthy controls matched for age, gender, and BMI.

Results

Mean age in the RPS group was 12.8 ± 3.3 years, and 49.1% of the group were female. Among the RPS patients, 28 were diagnosed with HT based on ABPM, of which 18 (32.7%) had an office BP < 90th percentile for age, gender, and height; seven had an office BP between the 90–95th percentiles for age, gender, and height; and three had an office BP > 95 percentile for age, gender, and height. The difference in detection of HT based on ABPM between the two groups was significant (P = 0.00).

Conclusions

Early diagnosis of HT via ABPM can help prevent development of kidney failure and cardiovascular disease in patients with RPS, significantly reducing the rates of morbidity and mortality. All children with RPS should be evaluated via ABPM, even if office BP measurements are normal.

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Acknowledgements

The authors gratefully acknowledge Mr. Scott Evans for English language editing.

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Authors and Affiliations

  1. Doktor Sami Ulus Cocuk Hastanesi: SBU Ankara Dr Sami Ulus Kadin Dogum Cocuk, Sagligi ve Hastaliklari Egitim ve Arastirma Hastanesi, Ankara, Turkey

    Deniz Karakaya, Evrim Kargın Çakıcı, Fatma Yazılıtaş, Tülin Güngör, Evra Çelikkaya, Esra Bağlan & Mehmet Bülbül

  2. Department of Pediatric Nephrology, Dr. Sami Ulus Maternity and Child Health and Diseases Training and Research Hospital, Ankara, Turkey

    Deniz Karakaya

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  1. Deniz Karakaya
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  2. Evrim Kargın Çakıcı
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Contributions

Study concept and design: Deniz Karakaya, Evrim Kargın Çakici, Mehmet Bülbül.

Analysis and interpretation of data: Deniz Karakaya, Tülin Güngör, Fatma Yazilitaş.

Drafting of the manuscript: Deniz Karakaya, Tülin Güngör, Evra Çelikkaya.

Critical revision of the manuscript for important intellectual content: Deniz Karakaya, Evrim Kargın Çakici, Esra Bağlan.

Corresponding author

Correspondence to Deniz Karakaya.

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Ethics approval

The study protocol was approved by the Dr. Sami Ulus Training and Research Hospital Ethics Committee.

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Informed consent was obtained from all individual participants included in the study.

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The authors declare no competing interests.

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Karakaya, D., Çakıcı, E.K., Yazılıtaş, F. et al. The importance of ambulatory blood pressure monitoring for diagnosing masked hypertension in patients with renal parenchymal scarring. Pediatr Nephrol 38, 1215–1222 (2023). https://doi.org/10.1007/s00467-022-05754-4

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  • DOI: https://doi.org/10.1007/s00467-022-05754-4

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