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A holey pursuit: lumen formation in the developing kidney

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Abstract

The formation of polarized epithelial tubules is a hallmark of kidney development. One of the fundamental principles in tubulogenesis is that epithelia coordinate the polarity of individual cells with the surrounding cells and matrix. A central feature in this process is the segregation of membranes into spatially and functionally distinct apical and basolateral domains, and the generation of a luminal space at the apical surface. This review examines our current understanding of the cellular and molecular mechanisms that underlie the establishment of apical–basal polarity and lumen formation in developing renal epithelia, including the roles of cell–cell and cell–matrix interactions and polarity complexes. We highlight growing evidence from animal models, and correlate these findings with models of tubulogenesis from other organ systems, and from in vitro studies.

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Abbreviations

CM:

Cap mesenchyme

MET:

Mesenchymal to epithelial transition

MM:

Metanephric mesenchyme

NCAM:

Neural cell adhesion molecule

PA:

Pretubular aggregate

PKD:

Polycystic kidney disease

RV:

Renal vesicle

UB:

Ureteric bud

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Acknowledgements

I thank David Bryant, Tom Carroll, and the reviewers for comments on the manuscript. This review was supported by Basil O’Connor Starter Scholar Research Award no. 5-FY13-201 from the March of Dimes Foundation, Satellite Healthcare Coplon Grant, and NIH R01DK099478.

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  1. Department of Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390-8856, USA

    Denise K. Marciano

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Correspondence to Denise K. Marciano.

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Marciano, D.K. A holey pursuit: lumen formation in the developing kidney. Pediatr Nephrol 32, 7–20 (2017). https://doi.org/10.1007/s00467-016-3326-4

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