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Relationship between serum IgA/C3 ratio and severity of histological lesions using the Oxford classification in children with IgA nephropathy

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An Erratum to this article was published on 03 February 2015

Abstract

Background

The aim of this study was to evaluate the usefulness of serum immunoglobulin A/complement factor 3 (IgA/C3) ratio for predicting histological severity of kidney lesions in children with IgA nephropathy (IgAN) based on World Health Organization (WHO) and the Oxford classification (OC).

Methods

We studied 89 children with IgAN with a mean age of 11.38 ± 4.1 years (range 2–18 years). Based on available medical records, we retrospectively evaluated clinical data, IgA/C3 ratio, and kidney biopsy findings using the five-grade WHO classification and the OC The mesangial hypercellularity (M), endocapillary hypercellularity (E), segmental sclerosis (S), tubular atrophy/interstitial fibrosis (T) (MEST) score (absent = 0, present = 1) calculated as the sum of M+E+S+T ranging from 0 to 4.

Results

Mean IgA/C3 ratio values were significantly higher (P < 0.05) in patients with M1, S1, and T1 compared with M0, S0, and T0, respectively (P < 0.05); there were no differences in the WHO classification. We found a significant positive correlation between the IgA/C3 ratio and proteinuria (r = 0.24) and determined optimal cutoff values of the IgA/C3 ratio, with a corresponding confidence interval for specific MEST scores.

Conclusions

The IgA/C3 ratio in children with IgAN may be a useful marker of the severity of lesions found in kidney biopsy as evaluated using the OC.

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Authors and Affiliations

  1. Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland

    Małgorzata Mizerska-Wasiak, Agnieszka Turczyn & Maria Roszkowska-Blaim

  2. Department of Pathology, Medical University of Warsaw, Warsaw, Poland

    Jadwiga Małdyk

  3. Department of Pediatrics and Nephrology, Medical University of Bialystok, Bialystok, Poland

    Agnieszka Rybi-Szumińska & Anna Wasilewska

  4. Department of Pediatric Nephrology, Children’s University Hospital of Cracow, Cracow, Poland

    Monika Miklaszewska & Jacek Pietrzyk

  5. Department of Pediatrics and Nephrology, Children’s Hospital, Torun, Torun, Poland

    Agnieszka Firszt-Adamczyk & Roman Stankiewicz

  6. Department of Pediatric Nephrology, Medical University of Lublin, Lublin, Poland

    Beata Bieniaś & Małgorzata Zajączkowska

  7. Department of Nephrology & Kidney Transplantation, The Children’s Memorial Health Institute, Warsaw, Poland

    Katarzyna Gadomska-Prokop & Ryszard Grenda

  8. Department of Pediatric Nephrology, Wroclaw Medical University, Wroclaw, Poland

    Agnieszka Pukajło-Marczyk & Danuta Zwolińska

  9. Department and Clinic of Pediatrics, Medical University of Silesia, Zabrze, Poland

    Maria Szczepańska

Authors
  1. Małgorzata Mizerska-Wasiak
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  2. Jadwiga Małdyk
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  15. Maria Szczepańska
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  16. Agnieszka Turczyn
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Corresponding author

Correspondence to Małgorzata Mizerska-Wasiak.

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Mizerska-Wasiak, M., Małdyk, J., Rybi-Szumińska, A. et al. Relationship between serum IgA/C3 ratio and severity of histological lesions using the Oxford classification in children with IgA nephropathy. Pediatr Nephrol 30, 1113–1120 (2015). https://doi.org/10.1007/s00467-014-3024-z

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  • DOI: https://doi.org/10.1007/s00467-014-3024-z

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