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The EYA-SO/SIX complex in development and disease

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Abstract

Eyes absent (EYA) and Sine oculis (SO/SIX) proteins function as transcriptional activation complexes and play essential roles in organogenesis during embryonic development in regulating cell proliferation and survival and coordination of particular differentiation programs. Mutations of the Eya and So/Six genes cause profound developmental defects in organisms as diverse as flies, frogs, fish, mice, and humans. EYA proteins also possess an intrinsic phosphatase activity, which is essential for normal development. Here, we review crucial roles of EYA and SO/SIX in development and disease in mice and humans.

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Acknowledgments

The author wishes to thank all of the past and present members of my lab for their many contributions and valuable discussions. Some of the work presented was supported by grants from the National Institutes of Health to P-X. X (NIH RO1 DC005824 and DK064640).

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  1. Department of Genetics and Genomic Sciences and Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY, 10029, USA

    Pin-Xian Xu

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Xu, PX. The EYA-SO/SIX complex in development and disease. Pediatr Nephrol 28, 843–854 (2013). https://doi.org/10.1007/s00467-012-2246-1

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  • DOI: https://doi.org/10.1007/s00467-012-2246-1

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