Abstract
Background
Patients receiving chronic dialysis therapy are presumed to be at risk for 25(OH) D3 deficiency, but little information is available on its prevalence, manifestations of deficiency, and the impact of ergocalciferol supplementation.
Methods
A single-center, retrospective study of 51 prevalent pediatric patients on hemodialysis or peritoneal dialysis was conducted to address these issues.
Results
Forty of 51 (78.4 %) patients had low (<30 ng/ml) 25(OH) D3 levels. Of these, 2 % had values < 5 ng/ml, 41.2 % 5–15 ng/ml, and 35.3 % 16–30 ng/ml. Age >12 years, non-Caucasian race and > 12-month duration of dialysis were significantly associated with low 25(OH) D3 levels (p = 0.006, p = 0.05, and p = 0.04, respectively). Twenty-three of the 40 patients deficient in 25(OH) D3 received repletion therapy with ergocalciferol and had a follow-up level at an average of 2 months following completion of a single course of therapy; 14 (60 %) of the levels were normal. Mean baseline intact parathyroid hormone (iPTH) for patients with 25(OH) D3 levels ≤ 30 was 478.68 ± 474.01 pg/ml and treatment with ergocalciferol was not associated with a significant decrease in the mean iPTH value (p = 0.45).
Conclusions
We conclude that low 25(OH) D3 levels are common in pediatric patients receiving dialysis and require attention in accordance with current practice guidelines.
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References
Holick MF (2007) Vitamin D deficiency. N Engl J Med 357:266–281
Seeherunvong W, Abitbol C, Chandar J, Zilleruelo G, Freundlich M (2009) Vitamin D insufficiency and deficiency in children with early chronic kidney disease. J Pediatr 154:906–911
Stein D, Feldman H, Gordon C (2012) Vitamin D status in children with chronic kidney disease. Pediatr Nephrol. doi:10.1007/s00467-012-2143-7
Moe S, Drueke T, Cunningham J, Goodman W, Martin K, Olgaard K, Ott S, Sprague S, Lameire N, Eknoyan G (2006) Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int 69:1945–1953
Belostotsky V, Mughal MZ, Berry JL, Webb NJA (2008) Vitamin D deficiency in children with renal disease. Arch Dis Child 93:959–962
Ali FN, Arguelles LM, Langman CB, Price HE (2009) Vitamin D deficiency in children with chronic kidney disease: uncovering an epidemic. Pediatrics 123:791–796
Wesseling-Perry K, Pereira R, Sahney S, Gales B, Wang H, Elashoff R, Juppner H, Salusky I (2011) Calcitriol and doxercalciferol are equivalent in controlling bone turnover, suppressing parathyroid hormone, and increasing fibroblast growth factor-23 in secondary hyperparathyroidism. Kidney Int 79:112–119
Baeke F, Gysemans C, Korf H, Mathieu C (2010) Vitamin D insufficiency: implications for the immune system. Pediatr Nephrol 24:1597–1606
Bhan I, Burnett-Bowie S, Ye J, Tonelli M, Thadhani R (2010) Clinical measures identify vitamin D deficiency in dialysis. Clin J Am Soc Nephrol 5:460–467
National Kidney Foundation (2005) K/DOQI clinical practice guidelines for bone metabolism and disease in children with chronic kidney disease. Am J Kidney Dis 46:S1–S121
Holick MF (1987) Vitamin D and the kidney. Kidney Int 32:912–929
Zehnder D, Landray MJ, Wheeler DC, Fraser W, Blackwell L, Nuttall S, Hughes SV, Townend J, Ferro C, Baigent C, Hewison M (2007) Cross-sectional analysis of abnormalities of mineral homeostasis, vitamin D and parathyroid hormone in a cohort of pre-dialysis patients. The chronic renal impairment in Birmingham (CRIB) study. Nephron Clin Pract 107:c109–c116
Halloran BP, Schaefer P, Lifschitz M, Levens M, Goldsmith RS (1984) Plasma vitamin D metabolite concentrations in chronic renal failure: effect of oral administration of 25-hydroxyvitamin D3. J Clin Endocrinol Metab 59:1063–1069
Ritter CS, Armbrecht HJ, Slatopolsky E, Brown AJ (2006) 25-Hydroxyvitamin D3 suppresses PTH synthesis and secretion by bovine parathyroid cells. Kidney Int 70:654–659
Gordon CM, DePeter KC, Feldman HA, Grace E, Emans SJ (2004) Prevalence of vitamin D deficiency among healthy adolescents. Arch Pediatr Adolesc Med 158:531–537
Cozzolino M, Gallieni M, Brancaccio D, Arcidiacono T, Bianchi G, Vezzoli G (2006) Vitamin D retains an important role in the pathogenesis and management of secondary hyperparathyroidism in chronic renal failure. J Nephrol 19:566–577
Chapuy MC, Preziosi P, Maamer M, Arnaud S, Galan P, Hercberg S, Meunier PJ (1997) Prevalence of vitamin D insufficiency in an adult normal population. Osteoporos Int 7:439–443
Khan S (2007) Vitamin D deficiency and secondary hyperparathyroidism among patients with chronic kidney disease. Am J Med Sci 333:201–207
Clemens TL, Adams JS, Henderson SL, Holick MF (1982) Increased skin pigment reduces the capacity of skin to synthesize vitamin D3. Lancet 1:74–76
Coburn JW, Koppel MH, Brickman AS, Massry SG (1973) Study of intestinal absorption of calcium in patients with renal failure. Kidney Int 3:264–272
Saha H (1994) Calcium and vitamin D homeostasis in patients with heavy proteinuria. Clin Nephrol 41:290–296
Langman CB, Brooks ER (2006) Renal osteodystrophy in children: a systemic disease associated with cardiovascular manifestations. Growth Horm IGF Res 16(Suppl A):S79–S83
Goodman WG, Goldin J, Kuizon BD, Yoon C, Gales B, Sider D, Wang Y, Chung J, Emerick A, Greaser L, Elashoff RM, Salusky IB (2000) Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med 342:1478–1483
Chavers BM, Li S, Collins AJ, Herzog CA (2002) Cardiovascular disease in pediatric chronic dialysis patients. Kidney Int 62:648–653
Fournier A, Harbouche L, Mansour J, Shahapuni I (2007) Impact of calcium and vitamin D therapy on arterial and cardiac disease in young adults with childhood-onset end-stage renal disease. Nephrol Dial Transplant 22:956–957
Prytula A, Wells D, McLean T, Balona F, Gullett A, Knott C, Cantwell M, Hassen K, Ledermann S, Rees L, Shroff R (2012) Urinary and dialysate losses of vitamin D-binding protein in children on chronic peritoneal dialysis. Pediatr Nephrol. doi:10.1007/s00467-011-2045-0
Shroff R, Wan M, Gullett A, Ledermann S, Shute R, Knott C, Wells D, Aitkenhead H, Manickavasagar B, Hoff W, Rees L (2012) Ergocalciferol supplementation in children with CKD delays the onset of secondary hyperparathyroidism: a randomized trial. Clin J Am Soc Nephrol 7(2):216–223
Hari P, Gupta N, Hari S, Gulati A, Mahajan P, Bagga A (2010) Vitamin D insufficiency and effect of cholecalciferol in children with chronic kidney disease. Pediatr Nephrol 25:2483–2488
Menon S, Rudolph P, Valentini RP, Hidalgo G, Peschansky L, Mattoo TK (2008) Vitamin D insufficiency and hyperparathyroidism in children with chronic kidney disease. Pediatr Nephrol 23:1831–1836
Matias P, Jorge C, Ferreira C, Borges M, Aires I, Amaral T, Gil C, Cortez J, Ferreira A (2010) Cholecalciferol supplementation in hemodialysis patients: effects on mineral metabolism, inflammation, and cardiac dimension parameters. Clin J Am Soc Nephrol 5:905–911
Shah N, Bernardini J, Piraino B (2005) Prevalence and correction of 25(OH) Vitamin D deficiency in peritoneal dialysis patients. Perit Dial Int 25:362–366
KDOQI Work Group (2009) KDOQI Clinical Practice Guideline for Nutrition in Children with CKD: 2008 update. Executive summary. Am J Kidney Dis 53(3 Suppl 2):S11–S104
Acknowledgments
We acknowledge the assistance of Guillermo Hidalgo, MD, who reviewed the manuscript, and Ashley Sherman who assisted in conducting the statistical analysis.
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Dibas, B.I., Warady, B.A. Vitamin D status of children receiving chronic dialysis. Pediatr Nephrol 27, 1967–1973 (2012). https://doi.org/10.1007/s00467-012-2203-z
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DOI: https://doi.org/10.1007/s00467-012-2203-z