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Microalbuminuria in children with primary and white-coat hypertension

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Abstract

Microalbuminuria serves as an early marker of hypertension-related renal damage in adults. However, data on the prevalence of microalbuminuria in paediatric hypertensive patients in general and in children with white-coat hypertension (WCH) specifically are lacking. The aim of our study was to investigate the prevalence of microalbuminuria in children with primary hypertension (PH) and WCH, respectively. This was a retrospective case review of children with PH and WCH treated at three paediatric nephrology centres. Untreated children with either form of hypertension for whom measurements of urinary albumin excretion (UAE) had been performed were enrolled in the study. The study cohort comprised 52 children (39 boys) with hypertension (26 children with PH, 26 with WCH). Microalbuminuria (>3.2 mg/mmol creatinine) was present in 20% of children with PH and none of the children with WCH (p < 0.01). Children with PH had a higher median UAE than those with WCH (1.27 ± 1.92 vs. 0.66 ± 0.46 mg/mmol creatinine, p < 0.05). Based on these results, we suggest that children with PH have an increased prevalence of microalbuminuria, while children with WCH show no signs of hypertension-related renal damage.

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Acknowledgments

This study was supported by grant VZ MZ CR No 0006420301 MZOFNM2005. We thank the colleagues from the Department of Biochemistry and Pathobiochemistry for measurements of urinary albumin concentration.

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Authors and Affiliations

  1. Department of Paediatrics, University Hospital Motol, 2nd School of Medicine, Charles University Prague, V Uvalu 84, 15006, Prague 5, Czech Republic

    Tomáš Seeman

  2. Department of Paediatrics, Friedrich-Schiller-University, Jena, Germany

    Michael Pohl & Ulrike John

  3. Department of Paediatrics, 3rd School of Medicine, Charles University Prague, Prague, Czech Republic

    Daniela Palyzova

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  1. Tomáš Seeman
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  2. Michael Pohl
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  3. Daniela Palyzova
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  4. Ulrike John
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Correspondence to Tomáš Seeman.

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Seeman, T., Pohl, M., Palyzova, D. et al. Microalbuminuria in children with primary and white-coat hypertension. Pediatr Nephrol 27, 461–467 (2012). https://doi.org/10.1007/s00467-011-2019-2

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  • DOI: https://doi.org/10.1007/s00467-011-2019-2

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