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Distinct metalloproteinase excretion patterns in focal segmental glomerulosclerosis

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Abstract

Metalloproteinase-2 (MMP-2) and metalloproteinase-9 (MMP-9) degrade type IV collagen, and represent important tissue remodeling enzymes in several kidney disorders. In this study, we measured urinary levels of MMP-2, MMP-9, and the tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in patients with steroid-sensitive nephrotic syndrome (SSNS, n = 18, median age 5) and focal segmental glomerulosclerosis (FSGS, n = 16, median age 15). We found that urinary concentrations of MMP-2, MMP-9, TIMP-1, and TIMP-2 were significantly elevated in FSGS patients as compared to SSNS in both relapse and remission (p < 0.002). Furthermore, urinary levels of these enzymes are increased early on in the FSGS disease process (chronic kidney disease stages 1 and 2). The findings from this pilot study suggest that MMPs and TIMPs have the potential to represent candidate, early non-invasive biomarkers for diagnosis and/or response to therapy. In addition, they may represent therapeutic targets for preventing chronic kidney disease progression in FSGS.

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Authors and Affiliations

  1. Division of Nephrology & Hypertension, Cincinnati Children’s Hospital and Medical Center, 3333 Burnet Ave, MLC 7022, Cincinnati, OH, 45229, USA

    Kimberly A. Czech, Michael Bennett & Prasad Devarajan

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  1. Kimberly A. Czech
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  2. Michael Bennett
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  3. Prasad Devarajan
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Correspondence to Kimberly A. Czech.

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Czech, K.A., Bennett, M. & Devarajan, P. Distinct metalloproteinase excretion patterns in focal segmental glomerulosclerosis. Pediatr Nephrol 26, 2179–2184 (2011). https://doi.org/10.1007/s00467-011-1897-7

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  • DOI: https://doi.org/10.1007/s00467-011-1897-7

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