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Problems with 'focal segmental glomerulosclerosis'

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Abstract

The term 'focal segmental glomerulosclerosis (FSGS)' has been applied to many different conditions. All classifications of 'FSGS', including those describing 'variants', perpetuate the misconceptions that the entities included have something in common and that the term 'FSGS' has some value. With a rigorous approach to renal biopsies showing segmental lesions, especially with knowledge of clinical circumstances and with detailed analysis of features such as the appearance of lesions and their position within glomeruli, a pathologist can provide information that is clinically more useful than merely the bald diagnosis 'FSGS'. More precise terms should be used. 'Overload changes' can be used to describe the changes seen in reduced renal mass. 'Tip changes' can be seen in many conditions and are not a disease in themselves. 'The glomerular tip lesion as originally defined' means the occurrence of tip changes in otherwise normal glomeruli, in the nephrotic syndrome. 'Early classical segmental sclerosing glomerulopathy' is the combination of tip changes and otherwise abnormal glomeruli, in the nephrotic syndrome. 'Late classical segmental sclerosing glomerulopathy' means segmental lesions at various sites within glomeruli, in the nephrotic syndrome. 'Collapsing glomerulopathy' is distinctive, and its inclusion in classifications emphasises the lack of specificity of 'FSGS'.

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Authors and Affiliations

  1. Department of Pathology, University College London, London, WC1E 6JJ, UK

    Alexander J. Howie

  2. Department of Cellular Pathology, Royal Free Hospital, London, NW3 2QG, UK

    Alexander J. Howie

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Correspondence to Alexander J. Howie.

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Howie, A.J. Problems with 'focal segmental glomerulosclerosis'. Pediatr Nephrol 26, 1197–1205 (2011). https://doi.org/10.1007/s00467-010-1701-0

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