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Lithium-induced membranous glomerulonephropathy in a pediatric patient

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Abstract

Lithium-induced glomerular toxicity is an infrequent occurrence in pediatric patients. We report a 13-year-old patient presenting with clinical and laboratory evidence of renal insufficiency after long-term lithium use. Biopsy revealed membranous glomerulonephropathy. Discontinuation of the lithium treatment resulted in resolution of the symptoms and laboratory abnormalities. Other alkali metals have been implicated as risk factors for membranous glomerulonephropathy. To the best of our knowledge, this is the first reported case of lithium-induced glomerulonephropathy in a pediatric patient.

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References

  1. Grünfeld J-P, Rossier BC (2009) Lithium nephrotoxicity revisited. Nat Rev Nephrol 5:270–276

    Article  Google Scholar 

  2. Markowitz GS, Radhakrishnan J, Kambham N, Valeri AM, Hines WH, D’Agati VD (2000) Lithium nephrotoxicity: a progressive combined glomerular and tubulointerstitial nephropathy. J Am Soc Nephrol 11:1439–1448

    CAS  PubMed  Google Scholar 

  3. Phan L, Coulomb F, Boudon M, Gallois H, Leinknecht D (1991) Extramembranous glomerulonephritis induced by lithium. Nephrologie 12:185–187

    CAS  PubMed  Google Scholar 

  4. Bosquet S, Descombes E, Gauthier T, Fellay G, Regamey C (1997) Nephrotic syndrome during lithium therapy. Nephrol Dial Transplant 12:2728–2731

    Article  CAS  Google Scholar 

  5. Wood IK, Parmelee DX, Foreman JW (1989) Lithium-induced nephrotic syndrome. Am J Psychiatry 146:84–87

    Article  CAS  Google Scholar 

  6. Sakarcan A, Thomas DB, O’Reilly KP, Richards RW (2002) Lithium-induced nephrotic syndrome in a young pediatric patient. Pediatr Nephrol 17:290–292

    Article  Google Scholar 

  7. Petersen CE, Amaral S, Frosch E (2008) Lithium-induced nephrotic syndrome in a prepubertal boy. J Child Adolesc Psychopharmacol 18:210–213

    Article  Google Scholar 

  8. Watanabe T (2002) Membranous glomerulonephritis in a patient with unilateral renal agenesis. Nephron 91:159–161

    Article  Google Scholar 

  9. Moskovitz R, Springer P, Urquhart M (1981) Lithium-induced nephrotic syndrome. Am J Psychiatry 138:382–383

    Article  CAS  Google Scholar 

  10. Aymaz S, Gross O, Krakamp B, Ortmann M, Dienes HP, Weber M (2001) Membranous nephropathy from exposure to mercury in the fluorescent-tube-recycling industry. Nephrol Dial Transplant 16:2253–2255

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Pediatric Nephrology, Women and Children’s Hospital of Buffalo, 219 Bryant Street, Buffalo, New York, 14222, USA

    Gunjeet K. Kala & James E. Springate

  2. Department of Pediatrics, Women and Children’s Hospital of Buffalo, Buffalo, New York, USA

    Muniza Mogri

  3. Department of Pathology, Buffalo General Hospital, Buffalo, New York, USA

    Edit Weber-Shrikant

Authors
  1. Gunjeet K. Kala
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  2. Muniza Mogri
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  3. Edit Weber-Shrikant
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  4. James E. Springate
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Correspondence to Gunjeet K. Kala.

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Kala, G.K., Mogri, M., Weber-Shrikant, E. et al. Lithium-induced membranous glomerulonephropathy in a pediatric patient. Pediatr Nephrol 24, 2267–2269 (2009). https://doi.org/10.1007/s00467-009-1245-3

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  • DOI: https://doi.org/10.1007/s00467-009-1245-3

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