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Arterial stiffness in children after renal transplantation

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Abstract

Long-term survival after successful transplantation is limited by cardiovascular disease. We studied changes in arterial function in children after renal transplantation. We measured pulse-wave velocity (PWV) and the augmentation index (AIX) as estimated from central pulse-wave analysis in 36 patients with a functioning kidney transplant (mean age 14 ± 3.4 years) and 49 healthy children (mean age 13.3 ± 3.3 years). Transplantation had been performed 4.3 ± 3.3 years prior to examination. Transplanted patients had a significantly higher mean PWV of 5.43 ± 0.9 m/s; controls 4.68 ± 0.7 m/s. Likewise, the AIX was significantly higher in patients (–14.3 ± 15.2) than in controls –26.3 ± 13.5. We found no significant associations with the degree of transplant dysfunction, glomerular filtration rate (GFR) loss, or dose of immunosuppressive medications; however, the AIX was associated with the serum calcium-phosphorus product, and PWV correlated with systolic blood pressure and age. This study suggests that subclinical arteriopathy is present in young transplant recipients.

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Authors and Affiliations

  1. Department of Pediatric Nephrology, Charité Universitätsmedizin Berlin, Berlin, Germany

    Sonia Briese, Maren Claus & Uwe Querfeld

  2. Department of Pediatric Nephrology, Charité University Hospital, Augustenburger Platz 1, D – 13353, Berlin, Germany

    Uwe Querfeld

Authors
  1. Sonia Briese
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  2. Maren Claus
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  3. Uwe Querfeld
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Correspondence to Uwe Querfeld.

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Briese, S., Claus, M. & Querfeld, U. Arterial stiffness in children after renal transplantation. Pediatr Nephrol 23, 2241–2245 (2008). https://doi.org/10.1007/s00467-008-0894-y

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  • DOI: https://doi.org/10.1007/s00467-008-0894-y

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