Abstract
The aim of this study was to investigate the etiology and treatment modalities and to determine mortality risks in hospitalized children with chronic renal failure (CRF) in Ho Chi Minh City, Vietnam. We reviewed the records of 310 children with CRF hospitalized in Ho Chi Minh City from January 2001 to December 2005. The average annual number cases was 4.8 per million child population native to Ho Chi Minh City. Median age was 14 years; 85% of patients were in end-stage renal failure. Associated illnesses were anemia (96%), hypertension (74%), and cardiopulmonary diseases (39%). Causes of CRF included glomerulonephritis (30%) and congenital/hereditary anomalies (20%), but in 50% of children, the etiology was unavailable. Seventy-three percent of cases with end-stage renal failure did not benefit from renal replacement therapy. During hospitalization, 47 patients (15%) died. Mortality risks were higher in young children (1–4 years), in boys, and in patients with acquired pathologies. Severe metabolic acidosis was the main predictive factor of mortality by multivariate regression analysis. Our data shows a poor outcome due to late referral and limited facilities for renal replacement therapy in children with CRF hospitalized in Ho Chi Minh City.
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Abbreviations
- CRF:
-
chronic renal failure
- ESRF:
-
end-stage renal failure
- pmcp:
-
per million child population
- GFR:
-
glomerular filtration rate
- FSGS:
-
focal segmental glomerulosclerosis
References
Barsoum RS (2006) Chronic kidney disease in the developing world. N Engl J Med 354:997–999
Schwartz GJ, Brion LP, Spitzer A (1987) The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children and adolescents. Pediatr Clin North Am 34:571–590
Dechaux M (1983) Principales explorations fonctionnelles. In: Royer P, Habib R, Mathieu H, Broyer M (eds) Néphrologie Pédiatrique. Flammarion Médecine-Sciences, Paris, pp 537–551
Levey AS, Coresh J, Balk E, Kausz AT, Levin A, Steffes MW, Hogg RJ, Perrone RD, Lau J, Eknoyan G (2003) National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann Intern Med 139:137–147
Suwa S, Tachibana K (1993) Standard growth charts for height and weight of Japanese children from birth to 17 years based on a cross-sectional survey of national data. Clin Pediatr Endocrinol 2:87–97
General office of Vietnam (2006) Population and population density by province. https://doi.org/www.gso.gov.vn/ Cited 12 Sep 2006
Hamed RMA (2002) The spectrum of chronic renal failure among Jordanian children. J Nephrol 15:130–135
Anochie I, Eke F (2003) Chronic renal failure in children: a report from Port Harcourt, Nigeria (1985–2000). Pediatr Nephrol 18:692–695
van der Heijden BJ, van Dijk PC, Verrier-Jones K, Jager KJ, Briggs JD (2004) Renal replacement therapy in children: data from 12 registries in Europe. Pediatr Nephrol 19:213–221
United States Renal Data System (2006) Annual data report: atlas of end-stage renal disease in the United States. National Institute of Health, National Institute of Diabetes and Digestive and Kidney Diseases. https://doi.org/www.usrds.org/atlas.htm. Cited 24 Aug 2006
Kamoun A, Lakhoua R (1996) End-stage renal disease of the Tunisian child: epidemiology, etiologies, and outcome. Pediatr Nephrol 10:479–482
Ojeda Duran S, Ochoa Ponce C, Ortiz Lopez H (1999) Experiencia de 10 años de transplante renal en niños en el Occidente de México. Arch Venez Pediatr 62(2):179
Yang JI, Yao Y (2004) Analysis of 1268 patients with chronic renal failure in childhood: a report from 91 hospitals in China from 1990 to 2002. Zhonghua Er Ke Za Zhi 42:724–730
Al-Eisa AA, Samhan M, Naseef M (2004) End-Stage Renal Disease in Kuwaiti Children: An 8-year Experience. Transplant Proc 36:1788–1791
Loirat C, Ehrich JHH, Geerlings W, Jones EHP, Landais P, Mallick NP, Margreiter R, Raine AEG, Salmela K, Selwood NH, Tufveson G, Valderrabano F (1994) Report on management of renal failure in children in Europe, XXIII, 1992. Nephrol Dial Transplant 9:26–40
North American Pediatric Renal Transplant and Collaborative Studies (2006) Annual report. https://doi.org/web.emmes.com/study/ped/annlrept/annlrept2006.pdf Cited 24 Aug 2006
Hattori S, Yosioka K, Honda M, Ito H (2002) The 1998 report of the Japanese National Registry data on pediatric end-stage renal disease patients. Pediatr Nephrol 17:456–461
Madani K, Otoukesh H, Rastegar A, Van Why S (2001) Chronic renal failure in Iranian children. Pediatr Nephrol 16:140–144
Miklovicova D, Cornelissen M, Cransberg K, Groothoff JW, Dedik L, Schroder CH (2005) Etiology and epidemiology of end-stage renal disease in Dutch children 1987–2001. Pediatr Nephrol 20:1136–1142
Bommer J, Locatelli F, Satayathum S, Keen ML, Goodkin DA, Saito A, Akiba T, Port FK, Young EW (2004) Association of predialysis serum bicarbonate levels with risk of mortality and hospitalization in the Dialysis Outcomes and Practice Patterns Study (DOPPS). Am J Kidney Dis 44:661–671
Ehrich JHH, El Gendi AA, Drukker A, Janda J, Stefanidis C, Verrier-Jones K, Collier J, Katz M (2005) Demography of paediatric renal care in Europe: organization and delivery. Nephrol Dial Transplant 20:297–305
Acknowledgments
Tran Thi Mong Hiep is supported by a grant from the Commission Universitaire pour le Développement, Projet Inter Universitaire Ciblé (CUD-PIC 2004), Belgian Ministry of Foreign Affairs, Brussels, Belgium.
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Mong Hiep, T.T., Janssen, F., Ismaili, K. et al. Etiology and outcome of chronic renal failure in hospitalized children in Ho Chi Minh City, Vietnam. Pediatr Nephrol 23, 965–970 (2008). https://doi.org/10.1007/s00467-008-0752-y
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DOI: https://doi.org/10.1007/s00467-008-0752-y